Automated Specimen Processing
FENWAL INC LOVO KIT WITH BAG ACCESS(A)6CS
Compatible with Lovo software version 3.0(1) Spinning membrane separation device with 21 μm membrane thickness and 4 μm diameter pores(1) Source product line with a 0.2 μm kit check vent(2) Solution lines, each a with solid plug(1) 800 mL In-Process bag with a swabable, needleless injection/extraction site(1) 800 mL Retentate bag with a twist-off spike port and a swabable, needleless injection/extraction site(1) 2.5 L Filtrate bag with a swabable, needleless injection/extraction site and a connection line with solid plug(1) Female luer pressure pod
Apexbio Technology LLC SGI-1776 free base 1025065-69-3 5mg
SGI-1776 free base (CAS 1025065-69-3) is an ATP-competitive inhibitor targeting Pim kinases a serine/threonine protein kinase family implicated in regulating cellular survival pathways It selectively inhibits all three isoforms Pim-1 Pim-2 and Pim-3 leading to decreased phosphorylation of downstream substrates involved in cell cycle regulation and apoptosis such as p21Cip1/WAF1 and Bad Cellular studies indicate that SGI-1776 induces G1 cell cycle arrest promotes apoptosis and overcomes chemoresistance mediated by multidrug resistance protein 1 (MDR1) in taxane-resistant prostate cancer cells
Apexbio Technology LLC SGI-1776 free base 1025065-69-3 50mg
SGI-1776 free base (CAS 1025065-69-3) is an ATP-competitive inhibitor targeting Pim kinases a serine/threonine protein kinase family implicated in regulating cellular survival pathways It selectively inhibits all three isoforms Pim-1 Pim-2 and Pim-3 leading to decreased phosphorylation of downstream substrates involved in cell cycle regulation and apoptosis such as p21Cip1/WAF1 and Bad Cellular studies indicate that SGI-1776 induces G1 cell cycle arrest promotes apoptosis and overcomes chemoresistance mediated by multidrug resistance protein 1 (MDR1) in taxane-resistant prostate cancer cells
TARGETMOL CHEMICALS INC SGI-1776 10MG
Also available in 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer Non-Hodgkins Lymphoma and Relapsed/Refractory Leukemias. purity: 99%
![Medchemexpress LLC N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine | 1025065-69-3 | MFCD16659064 | 100.0% | 405.42 g·mol⁻¹ | C20H22F3N5O | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000262499.png-250.jpg)
Medchemexpress LLC N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine | 1025065-69-3 | MFCD16659064 | 100.0% | 405.42 g·mol⁻¹ | C20H22F3N5O | 5 MG
SGI-1776 (free base) is a small-molecule inhibitor of the Pim family of serine/threonine kinases intended for laboratory research. It inhibits Pim-1, Pim-2, and Pim-3 with reported IC50 values of 7 nM, 363 nM, and 69 nM, respectively, and is supplied as a high-purity solid and solution for biochemical and cell-based studies. For research use only.
- Potent Pim kinase inhibition with reported IC50 values for Pim-1, Pim-2, and Pim-3.
- High purity suitable for biochemical and cell-based assays.
- Available in solid and solution formats for flexible experimental use.
- Applicable to kinase signaling, apoptosis, and cancer biology research.
- Delivered with supporting documentation such as COA and SDS for traceability.
Abcam Wiskostatin, N-WASP inhibitor, 50MG
MW 426.1 Da, Purity >99%. Selective neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. Binds the GTPase binding domain stabilising the autoinhibited conformation. Prevents activation of Arp2/3 complex in the actin cytoskeleton.
The product is subject to the following: Abcam Restricted Use Statement
LABORATORY INSTRUMENT SPECIALISTS LIS 10PER STANDARD SOLUTIONS
NC3853023 LIS 10PER STANDARD SOLUTIONS
Selleck Chemical LLC SGI-1776 free base S2198-10mM/1mL
SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay 50- and 10-fold selective versus Pim2 and Pim3 also potent to Flt3 and haspin SGI-1776 induces apoptosis and autophagy