Automated Specimen Processing
FENWAL INC LOVO KIT WITH BAG ACCESS(A)6CS
Compatible with Lovo software version 3.0(1) Spinning membrane separation device with 21 μm membrane thickness and 4 μm diameter pores(1) Source product line with a 0.2 μm kit check vent(2) Solution lines, each a with solid plug(1) 800 mL In-Process bag with a swabable, needleless injection/extraction site(1) 800 mL Retentate bag with a twist-off spike port and a swabable, needleless injection/extraction site(1) 2.5 L Filtrate bag with a swabable, needleless injection/extraction site and a connection line with solid plug(1) Female luer pressure pod
Apexbio Technology LLC SGI-1776 free base 1025065-69-3 5mg
SGI-1776 free base (CAS 1025065-69-3) is an ATP-competitive inhibitor targeting Pim kinases a serine/threonine protein kinase family implicated in regulating cellular survival pathways It selectively inhibits all three isoforms Pim-1 Pim-2 and Pim-3 leading to decreased phosphorylation of downstream substrates involved in cell cycle regulation and apoptosis such as p21Cip1/WAF1 and Bad Cellular studies indicate that SGI-1776 induces G1 cell cycle arrest promotes apoptosis and overcomes chemoresistance mediated by multidrug resistance protein 1 (MDR1) in taxane-resistant prostate cancer cells
TARGETMOL CHEMICALS INC SGI-1776 10MG
Also available in 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer Non-Hodgkins Lymphoma and Relapsed/Refractory Leukemias. purity: 99%
Apexbio Technology LLC SGI-1776 free base 1025065-69-3 50mg
SGI-1776 free base (CAS 1025065-69-3) is an ATP-competitive inhibitor targeting Pim kinases a serine/threonine protein kinase family implicated in regulating cellular survival pathways It selectively inhibits all three isoforms Pim-1 Pim-2 and Pim-3 leading to decreased phosphorylation of downstream substrates involved in cell cycle regulation and apoptosis such as p21Cip1/WAF1 and Bad Cellular studies indicate that SGI-1776 induces G1 cell cycle arrest promotes apoptosis and overcomes chemoresistance mediated by multidrug resistance protein 1 (MDR1) in taxane-resistant prostate cancer cells
![Medchemexpress LLC N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine | 1025065-69-3 | MFCD16659064 | 100.0% | 405.42 g·mol⁻¹ | C20H22F3N5O | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000262499.png-250.jpg)
Medchemexpress LLC N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine | 1025065-69-3 | MFCD16659064 | 100.0% | 405.42 g·mol⁻¹ | C20H22F3N5O | 5 MG
SGI-1776 (free base) is a small-molecule inhibitor of the Pim family of serine/threonine kinases intended for laboratory research. It inhibits Pim-1, Pim-2, and Pim-3 with reported IC50 values of 7 nM, 363 nM, and 69 nM, respectively, and is supplied as a high-purity solid and solution for biochemical and cell-based studies. For research use only.
- Potent Pim kinase inhibition with reported IC50 values for Pim-1, Pim-2, and Pim-3.
- High purity suitable for biochemical and cell-based assays.
- Available in solid and solution formats for flexible experimental use.
- Applicable to kinase signaling, apoptosis, and cancer biology research.
- Delivered with supporting documentation such as COA and SDS for traceability.
Selleck Chemical LLC SGI-1776 free base S2198-1g
SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay 50- and 10-fold selective versus Pim2 and Pim3 also potent to Flt3 and haspin SGI-1776 induces apoptosis and autophagy
ABclonal Technology WASP Rabbit pAb
The Wiskott-Aldrich syndrome (WAS) protein family shares a common domain structure and links signals from cell surface receptors to the actin cytoskeleton. Their diverse motifs suggest regulation by multiple stimuli and interactions with various proteins. These proteins associate with the small GTPase Cdc42, which regulates actin filament formation, and the Arp2/3 complex, a key cytoskeletal organizer. WAS is a rare X-linked recessive disorder marked by immune dysregulation and microthrombocytopenia, caused by mutations in the WAS gene. The WAS protein is cytoplasmic and expressed only in hematopoietic cells, which exhibit signaling and cytoskeletal defects in patients. An alternative transcript variant with a different 5 UTR has been reported, though its full-length sequence remains unclear.
ABclonal Technology WASP Rabbit pAb
The Wiskott-Aldrich syndrome (WAS) protein family shares a common domain structure and links signals from cell surface receptors to the actin cytoskeleton. Their diverse motifs suggest regulation by multiple stimuli and interactions with various proteins. These proteins associate with the small GTPase Cdc42, which regulates actin filament formation, and the Arp2/3 complex, a key cytoskeletal organizer. WAS is a rare X-linked recessive disorder marked by immune dysregulation and microthrombocytopenia, caused by mutations in the WAS gene. The WAS protein is cytoplasmic and expressed only in hematopoietic cells, which exhibit signaling and cytoskeletal defects in patients. An alternative transcript variant with a different 5 UTR has been reported, though its full-length sequence remains unclear.
![Medchemexpress LLC N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide | 1020149-73-8 | MFCD27937047 | 99.8% | 461.52 g/mol | C27H23N7O | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000222712.png-250.jpg)
Medchemexpress LLC N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide | 1020149-73-8 | MFCD27937047 | 99.8% | 461.52 g/mol | C27H23N7O | 5 MG
SGI-1027 is a non-nucleoside DNA methyltransferase (DNMT) inhibitor for research use that inhibits DNMT1, DNMT3A, and DNMT3B; reported IC50 values include 12.5 μM (DNMT1), 8 μM (DNMT3A), and 7.5 μM (DNMT3B).
- Non-nucleoside DNMT inhibitor active against DNMT1, DNMT3A, and DNMT3B.
- Reported IC50 values: DNMT1 12.5 μM, DNMT3A 8 μM, DNMT3B 7.5 μM.
- High supplied purity (~99.8%).
- Molecular formula C27H23N7O and molecular weight 461.52 g/mol.
- Available as solid and as a 10 mM DMSO solution for convenient use.
- Storage guidance provided for powder and solvent formats to preserve stability.
Abcam Wiskostatin, N-WASP inhibitor, 10MG
MW 426.1 Da, Purity >99%. Selective neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. Binds the GTPase binding domain stabilising the autoinhibited conformation. Prevents activation of Arp2/3 complex in the actin cytoskeleton.
The product is subject to the following: Abcam Restricted Use Statement
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