Oligonucleotides
AdipoGen ODN 1826 (Type B) Endotoxin-free (sterile), 3x1 mg
MW: 6,383g/mol, Synonyms: CpG ODN TLR9 Agonist: B Type (species: rodent). Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic oligonucleotides (ODN) that contain such CpG motifs (CpG ODNs) mimic microbial DNA. The innate immune system of vertebrates has the ability to recognize CpG motifs in microbial DNA via the Toll-like receptor (TLR) 9 if the CpG ODN were free of additional immune stimulatory contaminants often present in synthetic commercial CpG ODN preparations designed for molecular biology applications (i.e. PCR). Given that high quality CpG ODNs were used, a close link has been established between the expression of TLR9 on certain immune cell subsets and the modulation of the immune system by CpG DNA.
Cayman Chemical 1113 14dIhydro15keto Pro 100ug
A metabolite of PGD2; appears in plasma of normal males within 10 minutes of tritiated PGD2 infusion or inhalation
Cayman Chemical 1a 1b-dihomo Prostaglandin F2
A theoretical product of adrenic acid in the COX pathway; primarily produced in renal medulla where adrenic acid is selectively distributed
Cayman Chemical 1a 1b-dihomo Prostaglandin F2
A theoretical product of adrenic acid in the COX pathway; primarily produced in renal medulla where adrenic acid is selectively distributed
Cayman Chemical DNA MethyltrnsfRase 1 Monc 1ea
Antigen: synthetic peptide corresponding to amino acids 637-650 of human DNMT1 • Host: mouse, clone 60B1220.1 • Isotype: IgG1κ • Cross Reactivity: (+) human, mouse, and zebrafish DNMT1 • Application(s): ChIP, IHC (paraffin-embedded sections), IP, and WB • DNMT1 is constitutively expressed in proliferating cells. DNMT1 cooperates with retinablastoma tumor suppressor to repress transcription from promoters containing E2F-binding sites suggesting a link between DNA methylation and cancer cell proliferation.
Biotium DNA Ligase 1(1A9), CF488A conjugate, 0.1mg/mL
DNA Ligase I maintains the major DNA Ligase activity in proliferating cells by joining Okazaki fragments during lagging strand DNA replication. Human DNA Ligase I also has an essential role in DNA repair pathways, where it catalyzes the formation of phosphodiester bonds between adjacent 5' phosphoryl and 3' hydroxy termini at single breaks in duplex DNA molecules. In addition, DNA Ligase I plays a role in sealing nicks during excision repair. Similar to other DNA ligases, DNA Ligase I is built around a common catalytic core. Increased levels of DNA Ligase I are found in human tumors, as compared to benign tissues, as well as in peripheral blood lymphocytes. DNA Ligase I activity is altered in the chromosomal breakage deficit Bloom's syndrome (BS). Individuals with BS either have decreased levels of abnormally thermolabile DNA Ligase I or possess a dimeric form of this enzyme. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. C
Revvity Health Sciences Inc NEXTFLEX Rapid Directional RNA-Seq Kit 2.0
NEXTFLEX Rapid Directional RNA-Seq Kit 2.0