Oligonucleotides
BIOHIPPO AAV-KI67-Cre-WPRE-hGH-polyA
Recombinant adeno associated virus expressing Cre under the Ki67 promoter with WPRE and hGH polyA elements. The Cre dependent configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
BIOHIPPO AAV-GfaABC1D-Lck-tdTomato-WPRE-SV40-polyA
Recombinant adeno associated virus expressing TDTOMATO Lck-tdTomato under the GfaABC1D promoter with WPRE and hGH polyA elements. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
Miltenyi Biotec, Inc. CD43-VioGreen, human
Detection of human CD43+ cells.
This product is subject to the following: Miltenyi Biotec, Inc. Terms and Conditions of Sale For Products and Services
Cayman Chemical ZngIbrosIde R1 10mg
A triterpene saponin and an active metabolite of ginsenoside Ro; cytotoxic to B16/F10 murine melanoma cells (IC50 = 24.52 UG/ml); inhibits tube formation by HUVECs at 40 UG/ml; reduces tumor growth in a B16/F10 murine melanoma model at 25 mg/kg
Biotium CD43 (T-Cell Marker) (SPN/1766R), CF488A conjugate, 0.1mg/mL
This antibody recognizes a cell surface glycoprotein of 95/115/135 kDa (depending upon the extent of glycosylation), identified as CD43. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of the lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundan
Biotium SOX9 / SRY-box 9(rSOX9/2288), Biotin conjugate, 0.1mg/mL
The specificity of this monoclonal antibody to its intended target was validated by HuProt™ Array, containing more than 19, 000, full-length human proteins. Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Nucleus (Potential). Campomelic dysplasia (CMD1) : Rare, often lethal, dominantly inherited, congenital osteo-chondrodysplasia, associated with male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones, unusually small scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate, micrognathia, flat face and hypertelorism are common. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and phot
ABclonal Technology RK21687-5uleach DNA Adapter U
The Truncated DNA Adapter (UDI) Kit for MGI kits contain Unique Dual Index adapters designed for the MGI sequencing platform Using these products to construct libraries can result in libraries with dual unique indexes The truncated adapters offer higher ligation efficiency fewer adapter dimers and higher library yield The adapters in these kits are truncated and cannot be used for PCR-free library construction It is necessary to use MGI UDI Primers for at least 2-3 cycles to obtain a structurally complete library
Abcam GSK503, EZH2 methyltransferase inhibitor, 10MG
MW 526.7 Da. Potent (IC₅₀ = nM; Ki = 3 nM) and specific EZH2 methyltransferase inhibitor. Selective against EZH1 (IC₅₀ = 633 nM). At least 4000-fold selective over a panel of 20 other human methyltransferases. Highly selective against a range of human histone deacetylases, GPCRs, kinases and ion channels. Reduces cellular H3K27me3 levels. Inhibits growth of diffuse large B-cell lymphoma cells. Inhinits melanoma growth and metastasis in mouse models.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SR-8278, REV-ERBalpha antagonist, 5MG
MW 361.5 Da. REV-ERBα antagonist (EC₅₀ = 470 nM, REV-ERBα transcriptional repression activity). Stimulates the expression of gluconeogenesis genes G6Pase and PEPCK.
The product is subject to the following: Abcam Restricted Use Statement
![ABclonal Technology [KO Validated] Bax Rabbit pAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000135710.jpg-250.jpg)
ABclonal Technology [KO Validated] Bax Rabbit pAb
BAX (BCL2 Associated X) is a pro-apoptotic member of the BCL2 protein family, crucial in regulating apoptosis. It contains four Bcl-2 homology (BH1–BH4) domains and a C-terminal transmembrane domain. In healthy cells, BAX remains in the cytoplasm via interaction with anti-apoptotic proteins like BCL2L1 (Bcl-xL). Upon apoptotic stimuli, BAX undergoes a conformational change and translocates to the outer mitochondrial membrane, where it promotes apoptosis through two main mechanisms: interacting with the voltage-dependent anion channel (VDAC) to release cytochrome c, or forming oligomeric pores that permeabilize the membrane. Released cytochrome c activates caspase-3, triggering cell death. BAX is also a direct transcriptional target of p53 and plays a role in p53-mediated apoptosis, with p53 both regulating its expression and interacting with BAX to enhance its activity.
ABclonal Technology Phospho-EZH2/KMT6-T311 Rabbit pAb
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
Cayman Chemical ProstaglndIn F2 10mg
9β-hydroxy stereoisomer of PGF2α; much less active than PGF2α in antifertility and bronchoconstrictor activities; exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of PGF2α