Oligonucleotides
Biotium DNA Ligase 1(1A9), 0.2mg/mL
DNA Ligase I maintains the major DNA Ligase activity in proliferating cells by joining Okazaki fragments during lagging strand DNA replication. Human DNA Ligase I also has an essential role in DNA repair pathways, where it catalyzes the formation of phosphodiester bonds between adjacent 5' phosphoryl and 3' hydroxy termini at single breaks in duplex DNA molecules. In addition, DNA Ligase I plays a role in sealing nicks during excision repair. Similar to other DNA ligases, DNA Ligase I is built around a common catalytic core. Increased levels of DNA Ligase I are found in human tumors, as compared to benign tissues, as well as in peripheral blood lymphocytes. DNA Ligase I activity is altered in the chromosomal breakage deficit Bloom's syndrome (BS). Individuals with BS either have decreased levels of abnormally thermolabile DNA Ligase I or possess a dimeric form of this enzyme. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. C
ABclonal Technology Non-pAct -CateninS33/S37/T41
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete Finally this protein binds to the product of the APC gene which is mutated in adenomatous polyposis of the colon Mutations in this gene are a cause of colorectal cancer (CRC) pilomatrixoma (PTR) medulloblastoma (MDB) and ovarian cancer Alternative splicing results in multiple transcript variants
ABclonal Technology Von Hippel Lindau/VHL
This gene encodes a component of a ubiquitination complex The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF) which is a transcription factor that plays a central role in the regulation of gene expression by oxygen In addition to oxygen-related gene expression this protein plays a role in many other cellular processes including cilia formation cytokine signaling regulation of senescence and formation of the extracellular matrix Variants of this gene are associated with von Hippel-Lindau syndrome pheochromocytoma erythrocytosis renal cell carcinoma and cerebellar hemangioblastoma
ABclonal Technology Von Hippel Lindau/VHL
This gene encodes a component of a ubiquitination complex The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF) which is a transcription factor that plays a central role in the regulation of gene expression by oxygen In addition to oxygen-related gene expression this protein plays a role in many other cellular processes including cilia formation cytokine signaling regulation of senescence and formation of the extracellular matrix Variants of this gene are associated with von Hippel-Lindau syndrome pheochromocytoma erythrocytosis renal cell carcinoma and cerebellar hemangioblastoma
Cayman Chemical VHL LIgnd 1hydrochlorIde 25mg
A PROTAC building block; VHL E3 binding portion of BET PROTAC MZ1
Enzo Life Sciences ODN 2216 (TLRGRADE™) (synthetic) (BULK) (1mg)
CpG oligodeoxynucleotide (Type A) with mixed phosphodiester/phosphorothioate backbone. Specific ligand for human TLR9 (Toll-like receptor 9). Formulation: Lyophilized. Sterile. Long Term Storage: +4°C.
Biotium CD43 (T-Cell Marker) (rSPN/1094), CF740 conjugate, 0.1mg/mL
This antibody recognizes a cell surface glycoprotein of 95/115/135 kDa (depending upon the extent of glycosylation), identified as CD43. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low ab
American Research Products Inc Mouse ABCA1 ELISA Kit
This Mouse ATP Binding Cassette Transporter A1 (ABCA1) ELISA Kit is a precoated Sandwich ELISA assay designed to detect and quantify the target analyte in serum plasma tissue homogenates and other biological fluids This product is for Research Use Only
American Research Products Inc Human HMGA2 ELISA Kit
This Human High Mobility Group AT Hook Protein 2 (HMGA2) ELISA Kit is a precoated Sandwich ELISA assay designed to detect and quantify the target analyte in tissue homogenates cell lysates and other biological fluids This product is for Research Use Only
Medchemexpress LLC ODN 1826 | 202668-42-6 | 97.24% | 6364.10 | 1 MG
ODN 1826 is a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist. It induces NO and iNOS production, enhances apoptosis, and immune surveillance. It also increases aortic atherosclerotic plaque size and exhibits antitumor activity against lung cancer, glioma, and melanoma.
- Induces nitric oxide and iNOS production in macrophages
- Enhances apoptosis and immune surveillance
- Increases aortic atherosclerotic plaque size in a chronic vascular injury mouse model
- Exhibits antitumor activity against lung cancer, glioma, and melanoma
- Delays growth of subcutaneously implanted gliomas and increases infiltration of macrophages and B cells into tumors
Grainger LegendPlate Forward Wht/Blk Rectangular
The Grainger website offers a variety of legends for industrial push buttons, available in colors like red, green, yellow, blue, and white. Imprint options include "Start", "Stop", "Emergency Stop", "Reset", and custom choices. Made from durable materials like plastic and metal, these legends suit industrial environments. Mounting options include screw, adhesive, and snap-in. They ensure clear identification on control panels and machines. Grainger's catalog features trusted brands like Allen-Bradley, Eaton, and Schneider Electric.
