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IGF-I receptor (IGF1R) mediates insulin-like growth factor effects binding strongly to IGF1 Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways influencing cell survival protein synthesis and proliferation IGF1R also signals through JAK/STAT inhibiting JNK activation Hybrid receptors show variable binding to IGF1 and insulin IGF-I R Protein Human (His) is the recombinant human-derived IGF-I R protein expressed by E coli with N-6 His labeled tag
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
FGF-2 is a member of the fibroblast family involved in bone healing cartilage repair bone repair and nerve regeneration FGF-2 is also a mitotic promoter that accelerates cell proliferation FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway For example FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage respectively[1] FGF-2 is also a known carcinogen in GBM which contributes to glioma growth and vascularization[2] FGF basic/bFGF Protein Human (145a a His) consists of 145 amino acids produced by E coli with tag free
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Recombinant bovine basic fibroblast growth factor (bFGF/FGF-2) expressed in Pichia pastoris with an N-terminal His tag. Supplied as a lyophilized powder formulated for stability, it is suitable for cell culture and research applications involving angiogenesis, wound healing, and FGF signaling studies. Handling and storage guidance are provided with the product.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Recombinant human insulin-like growth factor 1 receptor (IGF1R) protein expressed in HEK293 cells and supplied as a His-tagged, 0.22 μm filtered solution in PBS (pH 7.4). The protein is provided for in vitro research applications requiring mammalian-expressed IGF1R with high purity and native-like posttranslational modifications. Stability and handling information should be followed as provided by the manufacturer.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More