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IGF-I receptor protein (human) is a recombinant, HEK293-expressed extracellular domain supplied as a filtered PBS solution for research applications involving IGF signaling, binding, and pathway studies.
Recombinant human IGF-I receptor expressed in HEK293 cells.
C-terminal His tag for detection and purification.
Amino acid range E31-N932 representing the extracellular domain.
Purity ≥95.0% by reducing SDS-PAGE.
Supplied as 0.22 μm filtered PBS, pH 7.4.
Store at -80°C; avoid repeated freeze-thaw cycles.
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Epidermal keratinocytes comprise 90 % of all cells found in the epidermis the outermost layer of skin. They produce keratin the intermediate filament largely responsible for skins barrier function. Through their interactions with epidermal melanocytes keratinocytes obtain melanin and store it as a means of protection from UV radiation.HEK provide an excellent model system to study many aspects of epithelial function and disease particularly those related to skin biology and toxicology as well as HPV infection. When grown on inserts and provided with the liquid/air interface HEK can differentiate into a stratified squamous epithelium and serve as a more physiological 3D tissue model for in vitro studies.
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The LONGR3 IGF-I Freeze Dried Powder is a highly potent, animal-free growth factor that enhances mammalian cell culture performance. It boosts cell density and viability while improving volumetric productivity by up to 62% over unsupplemented cultures. Distinct from traditional insulin, it specifically activates the type I IGF Receptor, ensuring superior signaling for cell proliferation. This product's enhanced stability and compatibility with various cell types make it an excellent choice for chemically-defined culture applications.
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FGF-2 is a member of the fibroblast family involved in bone healing cartilage repair bone repair and nerve regeneration FGF-2 is also a mitotic promoter that accelerates cell proliferation FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway For example FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage respectively[1] FGF-2 is also a known carcinogen in GBM which contributes to glioma growth and vascularization[2] FGF basic/bFGF Protein Human (145a a His) consists of 145 amino acids produced by E coli with tag free
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FGF-2 is a member of the fibroblast family involved in bone healing cartilage repair bone repair and nerve regeneration FGF-2 is also a mitotic promoter that accelerates cell proliferation FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway For example FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage respectively[1] FGF-2 is also a known carcinogen in GBM which contributes to glioma growth and vascularization[2] FGF basic/bFGF Protein Human (145a a) consists of 145 amino acids produced by E coli with tag free
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Epidermal melanocytes are pigment-producing cells located at the basal level of epidermis where they interact with keratinocytes via cellular processes called dendrites. Melanin the pigment produced by melanocytes and responsible for skin color is then transferred to keratinocytes where it is stored in vesicles called melanosomes located around the nucleus to provide protection from UV radiation. HEM maintain their characteristic shape in culture for many generations. They produce melanin and serve as a useful cell model for the studies of melanocyte proliferation and differentiation as well as progression of melanocytic neoplasia.
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