Cell Lines and Cell Cultures
ATCC C166; Yolk-Sac Endothelial Cells; Mouse (Mus musculus)
C166 is an endothelial cell line that was isolated from the yolk sac of a 12-day-old, mouse embryo. This cell line was deposited by R Auerbach and can be used in cardiovascular disease and stem cell research.
Eurofins Discoverx PathHunter CHO-K1 PTGIR β-Arrestin Cell Line, 2 vials. (93-0305C2)
The PathHunter PTGIR cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin I2, beraprost) based activation of PTGIR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTGIR and EA-tagged β-Arrestin-2. Activation of PTGIR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Genscript Corporation CHO-K1/BDCA2 Stable Cell Line
BDCA-2 is a novel type II C-type lectin which shows 50 7% sequence identity at the amino acid level to its putative murine ortholog the murine dendritic cell associated C-type lectin 2 In addition to its antigen capturing function BDCA-2 can mediate potent inhibition of induction of IFN- / expression in PDCs Production of IFN- / in response to several different types of viruses bacteria CpG-DNA dsRNA and SLE serum is by far the most prominent feature of PDCs
Biochain Institute Inc Frozen Tissue Section - Human Adult Normal: Heart: Pericardium, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Biochain Institute Inc Frozen Tissue Section - Human Adult Normal: Brain: Thalamus, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
ACROBiosystems CHO/Human CD79B Stable Cell Line Development Service
B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.
Eurofins Discoverx InCELL Hunter U2OS Bcl2L1-Bim Protein Binding Cell Line, 2 vials. (96-0037C3)
The InCELL Hunter U2OS Bcl2L1-Bim Protein Binding Cell Line provides an easy-to-use cell based assay to study small molecule drug candidates that disrupt protein binding. This kit assesses compound-based disruption of Bcl2L1-Bim binding via detection of Bim levels. This product uses EFC technology. The cell line included overexpresses Bcl2L1 target in an untagged form and Bim binding partner fused to ProLabel. When a compound engages the Bcl2L1 target protein, partner binding is disrupted and the destabilized Bim is degraded, leading to a loss of EFC signal upon addition of EA containing detection reagent. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter CHO-K1 GPR173 β-Arrestin Orphan GPCR Cell Line, 2 vials. (93-0380C2A)
The PathHunter GPR173 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR173 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR173 and EA-tagged β-Arrestin-2. Activation of GPR173 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. This is an orphan receptor without a known ligand. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Klebsiella pneumoniae; 6 x 0.3mL
Klebsiella pneumoniae subsp. pneumoniae strain PCI 602 (ATCC 10031-MINI-PACK) consists of 6 ready-to-use vials of ATCC 10031 frozen in 200 μL of glycerol stock, eliminating the need to rehydrate and culture the strain prior to use. Each vial is provided with a 2-D barcode for easy storage and tracking, as well as peel-off labels for fast and reliable recordkeeping. This product has applications in respiratory and infectious disease research, inhibition testing, and quality control.
Eurofins Discoverx Ready-to-Assay LH Glycoprotein Hormone Receptor Frozen Cells, 2 Vials of Cells. (HTS233LRTA)
The Ready-to-Assay LH Glycoprotein Hormone Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. luteinizing hormone, hCG) based activation of LHCGR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses LHCGR alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of LHCGR, the resulting calcium activity can be assayed in either detection mode. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
ATCC BC-1; Lymphoma; Human (Homo sapiens)
There is a Permit requirement: License form needed to be completed Material Transfer Agreement Addendum for Screening Application
The forms are available here: https://www.atcc.org/support/order-support/permits-and-restrictions
Eurofins Discoverx PathHunter CHO-K1 GPR139 β-Arrestin Cell Line, 2 vials. (93-0954C2)
The PathHunter GPR139 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. TC-O 9311) based activation of GPR139 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR139 and EA-tagged β-Arrestin-2. Activation of GPR139 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 AGTRL1 Gi Cell Line, 2 vials. (95-0147C2)
The cAMP Hunter AGTRL1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. apelin-13) based activation of AGTRL1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type AGTRL1, a naturally Gi/Go coupled GPCR. Upon activation of AGTRL1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Cayman Chemical 11-cIs RetInal 2mg
An inverse agonist of opsin; isomerizes to all-trans retinal to start the phototransduction cycle of mammalian vision; binds as a partial agonist to a G121L-mutated opsin; application to compound eyes restored moth visual sensitivity almost completely
Biochain Institute Inc Matched Pair - DNA - Human Primary Tumor and Normal Tissue: Liver, 2x10 ug/PK
BioChain's human DNA matched pair products include: Primary Pair (PP), Primary and Metastasis Pair (PM). PP consists of DNA prepared from primary tumor and its adjacent normal tissue; PM consists of DNA prepared from primary tumor and corresponding ponding metastatic tumor. Genomic DNA in each pair is prepared from the same donor. This product line is designed foridentifying tumor-specific genes and tumor metastatic genes.