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This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.
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This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
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The FUJIFILM Cellular Dynamics iCell Cardiac Fibroblasts Kit provides a reliable source of human induced pluripotent stem (iPS) cell-derived cardiac fibroblasts for cardiac research and drug discovery. These cells offer high purity and are ready-to-use upon thaw, making them ideal for various applications such as cardiac tissue engineering and drug screening.
Provides ≥0.5 x 10^6 viable cells per vial
Demonstrates >98% purity
Ready-to-use upon thaw
Cryopreserved and frozen state
Derived from healthy human donors
Available for complex co-culture systems
Applications in cardiac tissue engineering, fibrosis, remodeling, and inflammatory response studies
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The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene.
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