General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter EDG5 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0735C3)
The PathHunter EDG5 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of EDG5 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged EDG5. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting EDG5-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CRHR1 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0726C3)
The PathHunter CRHR1 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of CRHR1 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged CRHR1. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting CRHR1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Frozen Tissue Section - Human Adult Normal: Parathyroid, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
ATCC Pfizer Pneumococcal polysaccharide powder Type 54 (d15B) 200mg
Purified pneumococcal polysaccharide type 15B is manufactured by Pfizer, Inc. for small quantity distribution by ATCC. The pneumococcal polysaccharide type 15B can be used to assay for type-specific antibodies, research immune responses, and study immunodeficiencies.
Eurofins Discoverx ChemiScreen CXCR6 Chemokine Receptor Membrane Preparation, 1 vial. (HTS054M)
The ChemiScreen CXCR6 Chemokine Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of CXCR6 surface expression. ChemiScreen membrane preps can be used to screen for GPCR activity using GTPγS assays. Increased GPCR activation levels will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
ATCC Escherichia coli; Strain 2003-3014
Escherichia coli strain 2003-3014 is a whole-genome sequenced strain that was isolated from stool in Michigan. It is toxigenic and was confirmed by PCR to carry the stx1, stx2, and eae genes. This strain is serotype O26:H11 and it has applications for food testing, enteric disease research, and infectious disease research.
Eurofins Discoverx cAMP Hunter CHO-K1 OPRL1 Gi Cell Line, 2 vials. (95-0115C2)
The cAMP Hunter OPRL1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. orphanin FQ) based activation of OPRL1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type OPRL1, a naturally Gi/Go coupled GPCR. Upon activation of OPRL1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Parabacteroides; distasonis
Parabacteroides distasonis is a whole-genome sequenced bacterial type strain that produces superoxide dismutase and catalase. This culture can be used as a quality control strain for bioMerieux Vitek and IDS products and Remel RapID™ Systems.
Biochain Institute Inc Frozen Tissue Section - Lupus: Blood Vessel: Artery, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Biochain Institute Inc Frozen Tissue Section - Depression: Brain: Hippocampus, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Eurofins Discoverx PathHunter U2OS CXCR3 β-Arrestin Cell Line, 2 vials. (93-0271C3)
The PathHunter CXCR3 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL11/I-TAC) based activation of CXCR3 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CXCR3 and EA-tagged β-Arrestin-2. Activation of CXCR3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.