General Cell Lines and Cell Cultures
Biochain Institute Inc Paraffin Tissue Section - Human Skin Tumor: Basal Cell Carcinoma (Face), 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Biochain Institute Inc Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) V, 5 slides/PK
BioChain's human adult normal multiple tissue panels are designed for studying tissue specific cellular localization of genes or proteins of interest in different human normal tissues. Tissues mounted on positively charged glass slides are organized either by organs (major organ multiple tissue panels), or by integrated major systems (organ systems multiple tissue panels). Documentation of tissues' clinical histories is available upon request. Identical format total RNA Northern Blots are available, and cDNA from those tissues may also be available for PCR detection.
Eurofins Discoverx ChemiScreen 5-HT4B Serotonin Receptor Stable Cell Line, 2 vials. (HTS110C)
The ChemiScreen 5-HT4B Serotonin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serotonin/5-HT) based activation of HTR4B GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses HTR4B alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of HTR4B, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay BLT1 Leukotriene Receptor Frozen Cells, 2 Vials of Cells. (HTS042RTA)
The Ready-to-Assay BLT1 Leukotriene Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. leukotriene) based activation of LTB4R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses LTB4R alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of LTB4R, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen D2L Dopamine Receptor Stable Cell Line, 2 vials. (HTS039C2)
The ChemiScreen D2L Dopamine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. dopamine) based activation of DRD2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses DRD2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of DRD2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay GnRH Gonadotropin-Releasing Receptor Frozen Cells, 2 Vials of Cells. (HTS027RTA)
The Ready-to-Assay GnRH Gonadotropin-Releasing Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. gonadotropin-releasing hormone) based activation of GNRHR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GNRHR alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of GNRHR, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen MCH2 Melanin-concentrating Hormone Receptor Stable Cell Line, 2 vials. (HTS026C)
The ChemiScreen MCH2 Melanin-concentrating Hormone Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. MCH) based activation of MCHR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses MCHR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of MCHR2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen CCR2B Chemokine Receptor Membrane Preparation, 1 vial. (HTS007M)
The ChemiScreen CCR2B Chemokine Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of CCR2 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx Ready-to-Assay CB1 Cannabinoid Receptor Frozen Cells, 2 Vials of Cells. (HTS019RTA)
The Ready-to-Assay CB1 Cannabinoid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. cannabinoids, CP 55,940) based activation of CNR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CNR1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CNR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen CRF1 Receptor Stable Cell Line, 2 vials. (HTS023C)
The ChemiScreen CRF1 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CRH, sauvagine) based activation of CRHR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CRHR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CRHR1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen CRF1 Receptor Membrane Preparation, 1 vial. (HTS023M)
The ChemiScreen CRF1 Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of CRHR1 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.