General Cell Lines and Cell Cultures
Eurofins Discoverx Ready-to-Assay CALCRL Calcitonin Receptor Frozen Cells, 2 Vials of Cells. (HTS172RTA)
The Ready-to-Assay CALCRL Calcitonin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. parathyroid hormone) based activation of CALCRL GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CALCRL (and modulating protein RAMP1) alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CALCRL, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx PathHunter AVPR1A Total GPCR Internalization U2OS Cell Line, 2 vials. (93-0751C3)
The PathHunter AVPR1A Total GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of AVPR1A via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged AVPR1A and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the AVPR1A receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS SYK Activity Assay, 2 vials. (93-0865C3)
The PathHunter U2OS SYK Activity Assay is a stable, engineered cell line for use in studying small molecule drug candidates targeting the SYK kinase domain. The cell line is engineered to express the catalytic domain from SYK fused to the cytokine receptor binding domain (CRBD) of JAK2. The cells co-express an Enzyme Acceptor (EA) tagged SH2 domain and a ProLink (PK) tagged Cytokine receptor. The CRBD is designed to bind the CTK catalytic domain to the GHR-PK. Activation of the GHR-PK induces receptor phosphorylation by the SYK catalytic domain. This leads to SH2-EA recruitment and production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Cell Applications Inc Cryopreserved Aortic Endothelial Cells, Type 2 Diabetes (HAOEC-T2D), Adult
Cryopreserved Aortic Endothelial Cells, Type 2 Diabetes (HAOEC-T2D), Adult
Cell Applications Inc Cryopreserved Internal Thoracic Artery Endothelial Cells (HITAEC), Adult
Cryopreserved Internal Thoracic Artery Endothelial Cells (HITAEC), Adult
Cell Applications Inc Proliferating Coronary Artery Smooth Muscle Cells (HCASMC), Adult
Proliferating Coronary Artery Smooth Muscle Cells (HCASMC), Adult
Cell Applications Inc Proliferating Subclavian Artery Smooth Muscle Cells (HScASMC), Adult
Proliferating Subclavian Artery Smooth Muscle Cells (HScASMC), Adult
Biochain Institute Inc Paraffin Tissue Section - Arrhythmia, infarct: Heart Atrium, left, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from single human diseased sample. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Cell Applications Inc Cryopreserved Pulmonary Artery Smooth Muscle Cells (HPASMC), Adult
Cryopreserved Pulmonary Artery Smooth Muscle Cells (HPASMC), Adult
Cell Applications Inc Proliferating Pulmonary Artery Smooth Muscle Cells (HPASMC), Adult
Proliferating Pulmonary Artery Smooth Muscle Cells (HPASMC), Adult
Cell Applications Inc Proliferating Bovine Aortic Smooth Muscle Cells (BAOSMC)
Proliferating Bovine Aortic Smooth Muscle Cells (BAOSMC)
ATCC Methylorubrum extorquens; (u s patent 5,302,525)
Methylorubrum extorquens strain 58 is a bacterium that was isolated from oil-contaminated soil. It is cited to produce poly-beta-hydroxybutyric acid polymers.
Biochain Institute Inc Paraffin Tissue Section - Human Throat Tumor: Squamous Cell Carcinoma of Pharynx, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Cell Applications Inc Proliferating Bovine Brain Microvascular Endothelial Cells (BBMVEC)
Proliferating Bovine Brain Microvascular Endothelial Cells (BBMVEC)
Cell Applications Inc Proliferating Bovine Brain Microvascular Endothelial Cells (BBMVEC)
Proliferating Bovine Brain Microvascular Endothelial Cells (BBMVEC)