General Cell Lines and Cell Cultures

A variety of living cell lines and cell cultures suitable for a host of research and educational purposes.

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931 – 945 of 13,703 results

931

Eurofins Discoverx ChemiScreen TSH Glycoprotein Hormone Receptor Stable Cell Line, 2 vials. (HTS133C)

The ChemiScreen TSH Glycoprotein Hormone Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. TSH) based activation of TSHR (L) GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses TSHR alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of TSHR, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.

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932

Eurofins Discoverx ChemiScreen B2 Bradykinin Receptor Stable Cell Line, 2 vials. (HTS041C)

The ChemiScreen B2 Bradykinin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. bradykinin) based activation of BDKRB2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses BDKRB2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of BDKRB2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.

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933

ATCC pRS306 phagemid; in E. coli

One of a series of pBluescript-based integrating vectors (ATCC 77138-77141) differing in the yeast selectable marker gene. This is a YI-type (integrating shuttle vector ) permitting visual detection of recombinants and production of ssDNA in E. coli. It contains promoters for invitro RNA synthesis, priming sites useful for sequencing, and encodes the lacZ alpha (lacZ?) peptide. The pRSS56, base vector was constructed by ligating a PvuI fragment (bp 498-2412) of pBluescript KS+ to a PvuI fragment (bp 2850-730) of pBS(+). It contains the KS MCS from pBluescript KS+ and the unique NdeI and AatII sites between bla and the f1 origin of pBS(+). A fragment (1.112 kb) containing the URA3 gene was inserted into the NdeI site of pRSS56. All ends were blunted.

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934

ATCC Genomic DNA from; Halobacillus trueperi; Strain SL-5 [DSM 10404]

Genomic DNA isolated from Halobacillus trueperi strain SL-5. This bacterial strain is also available as ATCC Catalog No.: 700077™.

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935

Eurofins Discoverx ChemiScreen M1 Acetylcholine Muscarinic Receptor Stable Cell Line, 2 vials. (HTS044C)

The ChemiScreen M1 Acetylcholine Muscarinic Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. acetylcholine) based activation of CHRM1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CHRM1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CHRM1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.

Pricing & Availability

936

Eurofins Discoverx Ready-to-Assay ChemR23 Chemoattractant Receptor Frozen Cells, 2 Vials of Cells. (HTS071RTA)

The Ready-to-Assay ChemR23 Chemoattractant Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. chemerin) based activation of CMKLR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CMKLR1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CMKLR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.