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Cayman Chemical NorelgestromIn 50mg
An active metabolite of norgestimate; an agonist of the progesterone receptor and ERα (EC50s= 11.1 and 43.4 nM, respectively); an antagonist of the glucocorticoid and mineralocorticoid receptors (IC50s = 255 nM and 83.7 nM, respectively); selectively binds progestin receptors (IC50 = 4.61 nM for rabbit uterine receptors) over androgen receptors (IC50 = 222 nM for rat prostatic receptors); activates the androgen receptor in a transactivation assay in MDA-MB-231 cells expressing the human receptor
Cayman Chemical PIcoxystrobIn 100mg
A strobilurin fungicide; active against the plant pathogenic fungus R. herpotrichoides when used at 0.75 mg/L; induces tail deformities, pericardial edema, and spine curvature in zebrafish embryos at 100 UG/L; toxic to zebrafish embryos (LC50 = 213.8 UG/L)
Cayman Chemical AstragalosIde II 50mg
A triterpene saponin with diverse biological activities; increases the phosphatase activity of CD45 in cell-free assays using pNPP or OMFP as substrates (EC50s = 9.23 and 5.37 UG/ml, respectively); inhibits replication of dengue virus serotypes 1 and 3 in infected Vero cells (MIC = 1.56 UG/ml for both); increases concanavalin A-induced proliferation of primary mouse splenocytes at 30 nM; inhibits autophagy and enhances apoptosis induced by cisplatin in SGC-7901 gastric cancer cells at 50 µM; prevents decreases in small intestine and colon length, as well as body weight, in a mouse model of TNBS-induced colitis at 10 mg/kg; decreases the urinary albumin-to-creatinine ratio and improves histopathological scores in a rat model of STZ-induced diabetic nephropathy at 3.2 and 6.4 mg/kg
Cayman Chemical OseltamIvIrphosphate 100mg
An antiviral prodrug targeted against the influenza viruses; once hydrolyzed to its active metabolite, it can competitively inhibit viral neuraminidase (IC50s = 0.1-4.9 nM for influenza neuraminidases A and B)
Cayman Chemical AtrasentnhydrochlorIde 50mg
An ETA antagonist (Ki = 69 pM for the human receptor); selective for ETA over ETB (Ki = 139 nM for the human receptor) and a panel of 29 other receptors at 10 µM; inhibits endothelin-1-induced secretion of arachidonic acid from HPSMCs (pA2 = 10.5), as well as endothelin-1-induced vasoconstriction in isolated rat aortic rings (pA2 = 9.2); inhibits endothelin-1-induced increases in the pressor response in normotensive rats at 10 mg/kg; reduces urinary levels of albumin, TGF-β, and a PGE2 metabolite, as well as decreases the number of macrophages, in a rat model of streptozotocin-induced diabetic nephropathy at 5 mg/kg per day
Cayman Chemical 3-demethyl ColchIcIn 50mg
An active metabolite of colchicine; suppresses antibody production induced by sheep red blood cells in co-culture with isolated mouse spleen cells from 0.1-10 UG/ml; inhibits carrageenan-induced paw edema in rats at 100 UG/animal
Cayman Chemical Esomeprazole MagnsIum 50mg
A form of esomeprazole in complex with magnesium; reduces aceclofenac-induced ulcer area and lesion index in the stomach in a rat model of NSAID-induced gastric ulcer at 20 mg/kg
Cayman Chemical 3methoxy TyramInhydrochlo 50mg
A natural metabolite of dopamine; a weak agonist of TAAR1 (EC50 = 1.7 µM)
Cayman Chemical DIgItoxIgenIn 50mg
A cardenolide and aglycone constituent of digitoxin that elicits cardiac contraction and cardiotonic effects by inhibiting the Na+/K+ ATPase; inhibits protein synthesis and has been examined for use as an antitumor compound
Cayman Chemical ThymopentIn 50mg
A pentapeptide fragment of thymopoietin; induces prothymocyte differentiation in isolated mouse splenocytes at 0.018-18 µM; increases proliferation of, and phytohemagglutinin-stimulated IL-2 production in, isolated human PBLs at 1 UG/ml; reduces the number of splenic autologous rosette-forming cells in athymic mice at 0.02-10 mg/kg; adoptive cell transfer of splenocytes isolated from tumor-bearing mice administered thymopentin (100 ng/animal) reduces recipient tumor growth in a murine Lewis lung carcinoma model
Cayman Chemical SInIgrInhydrate 100mg
A glucosinolate; inhibits NLRP3 inflammasome activation in ATP-stimulated, LPS-primed RAW 264.7 cells in a concentration-dependent manner; reduces LPS-induced NO and PGE2 production, as well as NF-κB activation, in RAW 264.7 cells; induces cell cycle arrest at the G0/G1 phase in HepG2 hepatocellular carcinoma cells at 0.1 and 0.5 mM; increases in renal glomerular basement membrane thickness, as well as increases in systolic and diastolic blood pressure, in a rat model of angiotensin II-induced hypertension
Cayman Chemical FluorescamIn 50mg
An amine-reactive fluorescent probe; has commonly been used as a reagent in fluorometric protein assays; has commonly been used as a reagent in fluorometric protein assays; displays excitation/emission maxima of 370/488 nm, respectively, in acetone
Cayman Chemical IndocynIn Green 50mg
A vital fluorescent dye; binds to plasma proteins and lipoproteins; ex/em = 750-800/≥800 nm, respectively, with emission maximum shifting from 810-820 nm in aqueous solution to 820-834 nm following intravenous injection
Cayman Chemical aPIperIdInobutIophenonhyd 50mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications