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TGF- 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF- 1 superfamily that share a characteristic cystine knot structure TGF- 1 -2 and -3 are highly pleiotropic cytokines that act as cellular switches to regulate processes such as immune function proliferation and epithelial-mesenchymal transition Each TGF- isoform has some non-redundant function for TGF- 1 mice with targeted deletion show defects in hematopoiesis and endothelial differentiation and died of overwhelming inflammation TGF- 1 signaling begins with high-affinity binding to a type II ser/thr kinase receptor termed TGF- RII This receptor then phosphorylates and activates a second ser/thr kinase receptor TGF- RI (also called activin receptor like kinase (ALK)-5) or alternatively ALK-1 This complex phosphorylates and activates Smad proteins that regulate transcription
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Folate Receptor 1 (FOLR1) also known as Folate Receptor alpha and Folate Binding Protein (FBP) is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis the interconversion of glycine and serine and histidine breakdown FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells Has high affinity for folate and folic acid analogs at neutral pH
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Folate Receptor 1 (FOLR1) also known as Folate Receptor alpha and Folate Binding Protein (FBP) is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis the interconversion of glycine and serine and histidine breakdown FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells Has high affinity for folate and folic acid analogs at neutral pH
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Triple 0.1um sterile filtered, mycoplasma-tested and virus-screened, ships on dry ice. Store frozen at -20 to -10°C. Virus screened and mycoplasma tested. Lot number traceability.
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FBS Opti-Gold is good for many downstream application such as primary culture ,sub-culturing, vaccine production, protein production, transfection and other many application required for reduced FBS background.
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High-quality, high-viability (typically > 70%) rhesus monkey (or macaque) splenocytes sourced responsibly from a vetted third-party facility. Used for a wide variety of safety assessment and functional assays. All orders come with an iQ Certificate of Analysis.The following donor requests can be accommodated if inventory is available: - Single or multiple donors for a particular product (SKU). Indicate number of vials from each individual donor
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Innovative Grade US Origin Porcine Vitreous Humor Frozen 100ml - Innovative Grade US Origin Porcine Vitreous Humor from Innovative Research is collected on a custom basis from US Origin abattoir animals located in the United States, ensuring that only the highest-quality material is provided. This product is available fresh (refrigerated and shipped on wet ice) or frozen (stored at -20 to -80C and shipped on dry ice).
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Fetal Bovine Serum (500ml) or FBS is aseptically collected by cardiac puncture closed system, in the United States. Tissue Culture Biologicals is one of the few serum companies that collect and process Fetal Bovine Blood directly at the abattoirs. All fetal bovine serum products are obtained in approved abattoirs from cattle that have been tested to be free from disease. All bovine serum lots are viral tested as per 9CFR 113-53. Serum is endotoxin, mycoplasma screened and selected for its ability to support growth of a wide range of cell culture by the harvest to plant ratio method. Hemoglobin content <15 mg/dL. Endotoxin level < 2 EU/m
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More