Sera
Cayman Chemical PIcoxystrobIn 100mg
A strobilurin fungicide; active against the plant pathogenic fungus R. herpotrichoides when used at 0.75 mg/L; induces tail deformities, pericardial edema, and spine curvature in zebrafish embryos at 100 UG/L; toxic to zebrafish embryos (LC50 = 213.8 UG/L)
Cayman Chemical HalcInonIde 50mg
A synthetic glucocorticoid with anti-inflammatory properties; inhibits edema by 55% in a RPA test in rabbit when administered topically (0.1% w/w); inhibits edema by 70.1% and 88.0% in croton oil-induced and PCA tests, respectively, in rat (topical, 0.1% w/w); in vivo application (0.1% w/w) to the abraded surface of cecum in rats inhibits leukocyte adhesion (43.3% incidence versus 100% for controls) and lowers the total number of intraperitoneal leukocytes from 270 million to 121 million 3 days post surgery; acts as an agonist at the Smo receptor (EC50 = 1,100 nM)
Cayman Chemical AstragalosIde II 50mg
A triterpene saponin with diverse biological activities; increases the phosphatase activity of CD45 in cell-free assays using pNPP or OMFP as substrates (EC50s = 9.23 and 5.37 UG/ml, respectively); inhibits replication of dengue virus serotypes 1 and 3 in infected Vero cells (MIC = 1.56 UG/ml for both); increases concanavalin A-induced proliferation of primary mouse splenocytes at 30 nM; inhibits autophagy and enhances apoptosis induced by cisplatin in SGC-7901 gastric cancer cells at 50 µM; prevents decreases in small intestine and colon length, as well as body weight, in a mouse model of TNBS-induced colitis at 10 mg/kg; decreases the urinary albumin-to-creatinine ratio and improves histopathological scores in a rat model of STZ-induced diabetic nephropathy at 3.2 and 6.4 mg/kg
Cayman Chemical SB-271046hydrochlorIde 50mg
A selective, orally-available antagonist of the 5-HT6 receptor (pKi = 9.02-8.92); produces a significant increase in extracellular levels of glutamate and aspartate within the frontal cortex; used to evaluate the role of 5-HT6 in learning and memory
Cayman Chemical OseltamIvIrphosphate 100mg
An antiviral prodrug targeted against the influenza viruses; once hydrolyzed to its active metabolite, it can competitively inhibit viral neuraminidase (IC50s = 0.1-4.9 nM for influenza neuraminidases A and B)
Cayman Chemical PyrImethamIn 50mg
A dihydrofolate reductase inhibitor that prevents the production of tetrahydrofolic acid in P. falciparum and other protozoa; displays a prophylactic effect (ED50 = 0.5 mg/kg) in in vivo antimalarial mouse models
Cayman Chemical 3-demethyl ColchIcIn 50mg
An active metabolite of colchicine; suppresses antibody production induced by sheep red blood cells in co-culture with isolated mouse spleen cells from 0.1-10 UG/ml; inhibits carrageenan-induced paw edema in rats at 100 UG/animal
Cayman Chemical Esomeprazole MagnsIum 50mg
A form of esomeprazole in complex with magnesium; reduces aceclofenac-induced ulcer area and lesion index in the stomach in a rat model of NSAID-induced gastric ulcer at 20 mg/kg
Cayman Chemical DIgItoxIgenIn 50mg
A cardenolide and aglycone constituent of digitoxin that elicits cardiac contraction and cardiotonic effects by inhibiting the Na+/K+ ATPase; inhibits protein synthesis and has been examined for use as an antitumor compound
Cayman Chemical SInIgrInhydrate 100mg
A glucosinolate; inhibits NLRP3 inflammasome activation in ATP-stimulated, LPS-primed RAW 264.7 cells in a concentration-dependent manner; reduces LPS-induced NO and PGE2 production, as well as NF-κB activation, in RAW 264.7 cells; induces cell cycle arrest at the G0/G1 phase in HepG2 hepatocellular carcinoma cells at 0.1 and 0.5 mM; increases in renal glomerular basement membrane thickness, as well as increases in systolic and diastolic blood pressure, in a rat model of angiotensin II-induced hypertension
Cayman Chemical TrImethobenzamIDhydroCLOr 50mg
A D2 receptor antagonist and antiemetic; prevents apomorphine-induced emesis in dogs when administered at a dose of 20 mg/kg; stimulates contraction of isolated guinea pig ileum (ED50 = 8.7 μg/mL); decreases apomorphine-induced pecking responses in pigeons by 20% and increases the latent period of pecking from 4.3 to 8 minutes when used at a dose of 20 mg/kg; enhances compensation and decreases recovery time from 70 to 32 weeks in unilaterally labyrinthectomized cats, a model of vestibular injury, when administered at a dose of 6.7 g/kg per day for 2 weeks
Cayman Chemical N-MethylcytIsIn 100mg
An alkaloid with diverse biological activities; an nAChR agonist; selectively binds to nAChRs over mAChRs (IC50s = 0.05 and 417 µM, respectively); elicits whole-cell currents in Xenopus oocytes expressing α4β2, α4β4, and α7 subunit-containing nAChRs (EC50s = 13, 13, and 340 µM, respectively); nematocidal against B. xylophilus; inhibits LPS-induced NO production in RAW 264.7 macrophages (IC50 = 33.3 µM) and proliferation of SMMC-7721 cells at 4 mg/ml
Cayman Chemical ErlotInIbhydrochlorIde 100mg
An EGFR inhibitor (Ki = 2.7 nM); selective for EGFR over Src and Abl at 0.1 µM; induces caspase-3 and -7 activity in NCI H358 cells at 1 µM; reduces EGFR autophosphorylation in an HN-5 mouse xenograft model at 25 mg/kg
Cayman Chemical dgwota cysnta Tlosd 50mg
A flavonoid glycoside with diverse biological activities; inhibits CAVII (Ki = 4.6 nM); scavenges DPPH and superoxide radicals (IC50s = 12.8 and 42 µM, respectively); cytotoxic to Jurkat, HepG2, and COLO 205 cells (IC50s = 11.6, 14.3, and 55.4 µM, respectively); reduces TPA-induced EAr edema (ID50 = 0.357 mg/ear); decreases triglyceride accumulation in the liver and skeletal muscle in high-fat diet-fed KKAy diabetic mice at 100 mg/kg