Sera
Cayman Chemical -GalocatechIn 100mg
A polyphenol and flavonoid that has diverse biological activities; inhibits adherence of P. gingivalis onto human buccal epithelial cells by >50% at 250 μg/ml; has antimutagenic properties in UV-irradiated E. coli cells; inhibits cell death induced by D-galactosamine and TNF-α in primary cultured mouse hepatocytes by 29.9% at 80 μM; inhibits HCT116 colorectal cancer cell proliferation by 57% at 100 μM
Cayman Chemical GHK-Cuacetate 100mg
A complex of the tripeptide Gly-His-Lys and a copper(II) ion that has wound healing and anti-inflammatory activities; increases proliferation and the levels of collagen and secreted pro-MMP-2 in isolated human fibroblasts at 1 nM; increases levels of collagen, GAGs, and the expression of decorin in the wound tissue of rats at 2 mg; decreases LPS-induced increases in levels of ROS, IL-6, and TNF-α in RAW 264.7 cells at 10 µM; prevents LPS-induced decreases in lung SOD activity and GSH levels and reduces LPS-induced increases in the number of cells and the level of total protein in BALF in a mouse model of acute lung injury
Biotium Catenin, beta (p120) (5H10), Biotin conjugate, 0.1mg/mL
Beta-catenin associates with the cytoplasmic portion of E-cadherin. The catenin/cadherin complexes play an important role mediating cellular adhesion, including adherens junctions. Beta-catenin is involved in the Wnt signaling pathway as well as other signaling pathways, and is also found in complexes with many different proteins including the tumor suppressor protein APC. Defects in beta-catenin are associated with colorectal cancer, as well as many other cancer types. Beta-catenin is normally localized to the cell membrane, but can translocate to the nucleus in response to certain cell signaling. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other
Cayman Chemical N3oxohexadecnoylLHomose 50mg
An unusual, substituted, long-chain N-acyl-homoserine lactone (AHL) produced by some bacteria
Cayman Chemical IsoquercetIn 50mg
A flavonoid with diverse biological activities; reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay at 1 ng/ml; inhibits apoptosis, increases cell viability, and decreases the level of ROS in an oxygen-glucose deprivation/reoxygenation assay in primary rat hippocampal neurons at 25, 50, and 100 UG/ml; decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM); reduces infarct volume and neurological symptoms in a rat model of MCAO at 50 mg/kg
Cayman Chemical OlIvetolIc AcId 100mg
An analytical reference standard categorized as an intermediate in the phytocannabinoid biosynthetic pathway; a precursor in the synthesis of CBGA, Δ9-THC, and CBD; intended for research and forensic applications
Cayman Chemical 20 R-ProtopnaxadIol 50mg
A sapogenin with anticancer and antibacterial activities; has cytotoxic activity in MT-4 cells (CC50 = 6.1 µM); inhibits the growth of A549, SKOV3, SK-Mel-2, P388, L121, and K562 cells (ED50s = 11-26 µM); inhibits the growth of H. pylori in vitro (MICs = 50-100 UG/ml)
Cayman Chemical ADL5859hydrochlorIde 50mg
A δ-opioid receptor agonist (Ki = 0.84 nM); selective for δ-opioid receptors over μ-opioid and κ-opioid receptors at 10 μM; completely reverses CFA-induced mechanical hyperalgesia in rats at 3 mg/kg; decreases immobility time in the forced swim test in rats
Cayman Chemical N6-CyclohexyladenosIn 100mg
An adenosine receptor agonist; selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM); decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM, respectively); decreases heart rate and blood pressure in normotensive rats in vivo (EC25s = 2.4 and 4.2 μg/kg, respectively); induces sleep in rats via basal forebrain infusion at 100 μM; decreases locomotor activity in mice (ED50 = 60 μg/kg, i.p.)
Cayman Chemical NItIdInchlorIde 100mg
An alkaloid; active against the F32 chloroquine-sensitive (IC50 = 0.52 µM) and FcB1 and FcM2 chloroquine-resistant strains of P. falciparum (IC50s = 0.52, 0.8, and 0.49 µM, respectively) and reduces parasitemia in a mouse model of P. vinckei infection (ED50 = 18.9 mg/kg per day); decreases LPS-induced increases in TNF-α, IL-1β, and IL-6 levels and p65 nuclear translocation in RAW 264.7 cells at 5 µM; decreases serum levels of IL-10, TNF-α, and IL-6 and reduces mortality in a mouse model of LPS-induced endotoxemia; inhibits proliferation of various cancer cells (IC50s = 2.65-370 ng/ml); induces apoptosis and decreases STAT3 phosphorylation in HSC3 and HSC4 oral cancer cells from 0.1-10 µM and reduces tumor growth in an HSC3 mouse xenograft model at 10 mg/kg per day for 24 days
Cayman Chemical Talabostatmesylate 50mg
A non-selective inhibitor of DPPs (IC50s = >4, 310, 4, 11, 560, and 390 nM for DPP-4, DPP-7, DPP-8, DPP-9, FAP, and PREP, respectively); inhibits proliferation of superantigen-stimulated human PBMCs (IC50 = ~10 nM); increases expression of a variety of cytokines and chemokines in tumors and tumor-draining lymph nodes in a WEHI-164 fibrosarcoma mouse model at 5 μg twice per day; reduces tumor growth in a variety of syngeneic mouse models; increases the efficacy of the antitumor antibodies rituximab and trastuzumab in Namalwa B cell lymphoma and LS180 colon carcinoma mouse xenograft models, respectively
Cayman Chemical 5methyl2HOBAhydrochlorId 50mg
An isoketal scavenger; reduces angiotensin II-induced increases in systolic blood pressure in mice
Cayman Chemical Chlorfenapyr 50mg
A pyrrole pro-insecticide; metabolized in vivo into CL 303268; increases respiratory activity in vivo in German cockroaches at 1-10 UG/insect but not in vitro in Sf9 insect cells at 1-100 µM or isolated rat liver mitochondria; active against insects susceptible and resistant to pyrethroid and organophosphate insecticides, including mosquitoes that carry malaria (LC50s = 2-2.39% suspension impregnated on paper); lethal to rats (LD50s = 441 and 1,152 mg/kg for male and female rats, respectively)