Sera
Cayman Chemical GnglIosIde GM1porcInam 50mg
A mixture of ganglioside GM1; interacts with other proteins to increase calcium influx, affecting various calcium-dependent processes, including inducing neuronal outgrowth during differentiation; acts as a receptor for cholera toxin and the heat-labile enterotoxin from E. coli; induces apoptosis in activated T cells; found at higher levels on T cells isolated from patients with RCC; levels are decreased in the substantia nigra pars compacta in postmortem brain from patients with Parkinson’s disease accumulates in neurons in ganglioside GM1 gangliosidosis
Cayman Chemical QuIpazInmaleate 100mg
A 5-HT2A, 5-HT2B, and 5-HT2C receptor agonist; induces calcium accumulation in CHO-K1 cells expressing 5-HT2A, 5-HT2B, or 5-HT2C receptors (EC50s = 309.03, 177.83, and 338.84 nM, respectively, for the human receptors); binds to the 5-HT3 receptor (Ki = 2.1 nM); decreases food intake in rats at 2.5, 5, or 10 mg/kg; restores spinal circuitry function, improves gait regularity, and increases interlimb coordination and limb weight-bearing in a rat model of spinal cord transection-induced hindlimb paralysis at 0.3 mg/kg per day in combination with 8-hydroxy DPAT, electrode stimulation of dorsal and lumbar spine regions, and locomotor training
Cayman Chemical SodIum Ionphore III 50mg
A sodium-selective ionophore; has been used as component of sodium-selective liquid membrane electrodes for the quantification of sodium in aqueous solutions and blood serum
Cayman Chemical 3-bromo-7-NItroIndazole 50mg
3-Bromo-7-nitroindazole is a more potent inhibitor of nNOS than 7-nitroindazole in vitro, but unlike 7-nitroindazole, it is also potent against iNOS. The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.17, 0.86, and 0.29 µM, respectively.{1339}
Cayman Chemical EfaroxnhydrochlorIde 50mg
An α2-AR (EC50s = 1 receptor antagonist; binds to α2A-, α2B-, and α2C-ARs (Kis = 13, 38, and 1,820 nM, respectively) and selectively to I1 over I2 receptors (Kis = 52 and >10,000 nM, respectively); binds to putative I3 receptors on human pancreatic islets of Langerhans and stimulates insulin secretion at 100 μM; binds to rat RIN-5AH insulinoma cell membranes (IC50g = 32 nM) and stimulates insulin secretion at 100 μM; lowers basal blood glucose levels in mice at 5 mg/kg; increases L-DOPA synthesis in rat cortex and hippocampus by 77 and 57%, respectively at 10 mg/kg
Cayman Chemical PF-04418948 50mg
An orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM); over 1,000-fold less active at other prostanoid receptors, including other EP receptors
Cayman Chemical DIpIvefrInhydrochlorIde 50mg
A prodrug of epinephrine; reduces bovine primary trabecular meshwork cell density in vitro (IC50 = 115 µM); induces a fibroblast-like morphology and actin cytoskeleton disruption in cultured bovine primary trabecular meshwork cells (103 µM); enhances calcium signaling and induces cytotoxicity in cultured bovine corneal endothelial cells (28 µM); suppresses primary human corneal keratinocyte proliferation in vitro (280 µM)
Cayman Chemical ArachIdnyl CyclopropylaMD 50mg
A potent and selective CB1 receptor agonist (Kis = 2.2 and 715 nM for CB1 and CB2, respectively); induces hypothermia in mice with the same efficacy as AEA in spite of its much higher affinity for the CB1 receptor and thus is a possible substrate for FAAH
Cayman Chemical SpIromesIfen 100mg
An insecticide and acaricide; reduces lipid biosynthesis; inhibits acetyl-CoA carboxylase; inhibits chitinase from S. littoralis larvae (IC50s = 0.60 and 0.72 μM for enzyme isolated from lab and field strains, respectively); induces toxicity in whitefly nymphs (LC50 = 0.61 mg/L), spider mite eggs (LC50 = 0.16 mg/kg), and second instar larvae of S. littoralis lab and field strains (LC50s = 0.44 and 0.68 ppm, respectively, at 72 hours post-application); induces 50, 60, and 70% mortality in H. armigera, O. nubilalis, and P. xylostella, respectively, at 600 mg/kg; induces 100% mortality in M. separata at 100 mg/kg; induces toxicity in D. magna (EC50 = >0.092 mg a.s./L) and O. mykiss and L. macrochirus (LC50s = 0.016 and >0.034 mg a.s./L, respectively) but not rats (LD50 = >2,000 mg/kg); inhibits the human GST isozyme GSTA1-1 (IC50 = 12.1 μM)
Cayman Chemical C4 CeramIded18 14 0 50mg
A bioactive sphingolipid; inhibits IL-4 production by 16% in PMA-stimulated EL4 T cells at 10 μM; cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively); increases maturation and stability of F508del-CFTR proteins, enhances cAMP-activated chloride secretion, and suppresses secretion of IL-8 in primary epithelial cells isolated from patients with cystic fibrosis
Cayman Chemical MetIprnolol 50mg
A β-AR antagonist; binds to primary rabbit iris and ciliary body homogenates (Ki = 34 nM); inhibits isoproterenol-induced relaxation in guinea pig atrium and fenoterol-induced relaxation in rat uterus (pA2s = 8.3 and 8.4, respectively); inhibits anoxia-induced cell death in primary rat retinal cells and sodium nitroprusside-induced lipid peroxidation in rat primary retinal homogenates (100 μM); decreases α-chymotrypsin-induced increases in IOP in rabbits when administered topically to the eye at a dose of 0.3%; inhibits the blinking response to ocular tactile stimulation in rabbits when administered topically to the eye at a dose of 0.6%
Cayman Chemical DLaDIfluoromethylornIthIn 50mg
An irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis; displays antiangiogenic, cytostatic, and antiparasitic effects
Cayman Chemical FexapotIdetrIfluoroacetAT 50mg
A peptide with anticancer activity; induces apoptosis in LNCaP prostate cancer cells at 2.5 mg/ml; reduces the numbers of prostate glandular epithelial cells without affecting other cell types and decreases prostate volume in rats when administered intraprostatically at 0.6 mg/animal per week
Cayman Chemical DImaprIthydrochlorIde 50mg
A histamine H2 receptor agonist (Ki = 44 µM in guinea pig right atrium); selectively stimulates H2 over H1 and H3 receptors with relative potencies of 71, A. suum extract, which is not affected by pretreatment with mepyramine or cimetidine; stimulates gastric acid secretion in vivo in anaesthetized rats and cats with relative potencies of 19.5 and approximately 400 to 500, respectively, compared to histamine; inhibits 2-(2-pyridyl)ethylamine-induced bronchoconstriction in guinea pigs in a dose-dependent manner
Cayman Chemical 15 S-Latnoprost 50mg
A 15(S) isomer of latanoprost; reduces IOP in cynomolgus monkeys and does not induce eye irritation in cats when applied topically at 3 UG/eye; a potential impurity in commercial preparations of latanoprost