Sera
Pel Freez Biologicals Pooled Human OTC Serum (Neat) Heat Inactivated
Human serum, pooled, 0.2 micron filtered, bottled, heat-inactivated for 30 minutes at 56°C and frozen.
Cayman Chemical LInoleoyl EthnolamIde 50mg
An endocannabinoid that contains linoleate in place of the arachidonate moiety of AEA; has been detected in porcine brain and murine peritoneal macrophages and has weak affinity for the CB1 and CB2 receptors (Kis =10 µM and 25 µM, respectively); 4-fold less potent than AEA at causing catalepsy in mice (ED50 = 26.5 mg/kg); increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5 fold at 15 µM in a CB-receptor-independent manner; inhibits human FAAH-dependent hydrolysis of AEA (Ki = 9.0 µM), but is also effectively hydrolyzed by the enzyme
Cayman Chemical 3 4trImethylenaPyrrolId 50mg
A cathinone whose physiological and toxicological properties are not known
Cayman Chemical EfonIdIpIn 100mg
An L- and T-type calcium channel inhibitor; inhibits hamster Cav1.2a and human Cav3.2 (IC50s = 1.8 and 350 nM, respectively); inhibits L- and T-type calcium channels and fetal bovine serum-induced hypertrophy in isolated mouse cardiomyocytes; increases survival in a mouse model of acute myocardial infarction induced by ligation of the left coronary artery at 200 mg/kg; inhibits SARS-CoV-2 Mpro (IC50 = 38.5 µM)
Cayman Chemical N1AcetylspermInhydrochLR 50mg
A monoacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine
Cayman Chemical 22 S 23 S-HomobrasInolIde 50mg
A synthetic brassinosteroid; increases the rooting percentage in P. abies cuttings when applied topically at 60 ppm
Cayman Chemical Flumethason 50mg
An agonist of glucocorticoid and mineralocorticoid receptors (EC50s = 0.26 and 0.494 nM, respectively, in CV-1 cells expressing human receptors); inhibits the growth of UM-UC-3, TCC-SUP, and 5637 urothelial carcinoma cell lines (100 nM); decreases TNF production ex vivo in blood cells collected by BAL from calves with experimentally-induced local lung inflammation (5 mg per animal); impairs cell cycle re-entry of cardiac cells seven days post cryo-injury to the heart and impairs cardiac regeneration in vivo in zebrafish (5 μM)
Cayman Chemical Bromoenol lacton 50mg
BEL is a selective, irreversible, mechanism-based inhibitor of iPLA2 with a Ki value of 180 nM.{1631} It inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM.{1291,1770}
Cayman Chemical ColchIcosIde 50mg
A glycoside form of 3-demethylcolchicine; does not displace [3H]-colchicine from rat brain tubulin in vitro at 25 μM; increases CYP2C9 and CYP2E1 levels in primary human hepatocytes at 1 and 10 μM
Cayman Chemical N1 2 3DI 9octadecenoylox 50mg
A mixture of the cationic lipid isomers DOTMA and N-[1-(2,3-dielaidoyloxy)propyl]-N,N,N-trimethylammonium
Cayman Chemical SecnIdazole 100mg
A 5-nitroimidazole derivative with antiparasitic and antibiotic activity; exhibits a mean minimum inhibitory concentration of 2.59 µM against 16 clinical isolates of B. fragilis
Cayman Chemical 2 3 4 5-Tetrachlorophenol 50mg
A metabolite of γ-lindane; toxic to fathead minnows and rainbow trout (LC50s = 0.496 and 0.304 mg/L, respectively, in tank water)
Cayman Chemical PF-03814735 50mg
A reversible inhibitor of both Aurora A and B kinases (IC50s = 0.8 and 5 nM, respectively); also inhibits FLT1, FAK, TrkA, Met, and FGFR1 (IC50s = 10, 22, 30, 100, and 100 nM, respectively)
Cayman Chemical ClemIzolehydrochlorIde 50mg
An antihistamine that antagonizes the H1 receptor at high nanomolar concentrations; less potently blocks TRPC5 (IC50 = 1.0-1.3 µM), with at least 6-fold selectivity for TRPC5 over other TRP channels
Cayman Chemical Chrysnthemum LInarIn 50mg
A flavonoid glycoside with diverse biological activities; potentiates TRAIL-induced cytotoxicity and apoptosis in U87MG human glioma cells; potentiates TRAIL-induced tumor cell apoptosis and reduction of tumor growth in a U87MG mouse xenograft model; reduces pulmonary platelet count, edema, and macrophage, polymorphonuclear leukocyte, and lymphocyte infiltration, as well as inhibits TXNIP/NLRP3, MAPK, and NF-κB signaling in a mouse model of LPS-induced acute lung injury from 12.5-50 mg/kg; inhibits AChE and induces dyskinesia recovery in a zebrafish model of Alzheimer's disease in tank water at 50 μg/ml