Sera
Cayman Chemical MetaproterenolhemIsulfAT 100mg
A long-acting β2-AR agonist with bronchodilator actions; inhibits TGF-α-induced hepatocyte DNA syntheses and proliferation in vitro (IC50 = 15 nM); dose-dependently relaxes lung strips and increases heart rate and inotropy of right atria and left atria, respectively, isolated from guinea pig (pD2s = 6.4, 7.08, and 6.61, respectively)
Cayman Chemical Lersvrn 50mg
An NNRTI (mean IC50 = 118 nM for the wild-type HIV-1 enzyme); inhibits mutant HIV-1 RTs with mean IC50 values within 10-fold of the wild-type enzyme; inhibits HIV-1 virus replication in MT-2 cells (EC50s = 5.04, 13.1, and 34.9 nM at MOIs of 0.005, 0.05, and 0.5, respectively); exhibits synergistic or additive effects when used in combination with a variety of antiretroviral agents
Cayman Chemical IsoquercetIn 100mg
A flavonoid with diverse biological activities; reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay at 1 ng/ml; inhibits apoptosis, increases cell viability, and decreases the level of ROS in an oxygen-glucose deprivation/reoxygenation assay in primary rat hippocampal neurons at 25, 50, and 100 UG/ml; decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM); reduces infarct volume and neurological symptoms in a rat model of MCAO at 50 mg/kg
Cayman Chemical BucladesInsodIum salt 100mg
A cell-permeable, cyclic nucleotide derivative that mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor
Cayman Chemical DorIpenmhydrate 50mg
A broad-spectrum antibiotic; is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae (MICs = 0.03-0.06, 0.016-0.06, P. aeruginosa respiratory tract infection at 100 mg/kg per day
Cayman Chemical 3 4trImethylenaPyrrolId 50mg
A cathinone whose physiological and toxicological properties are not known
Cayman Chemical S-5-FluorowIlardIIn 50mg
An agonist of GluA1 and GluA2; selectively activates GluA1 and GluA2 over GluA3 and GluA4 in voltage-clamp assays using X. laevis oocytes expressing the flip isoforms of the rat receptors (EC50s = 0.382, 0.463, 20.9, and 11.9 µM, respectively); induces evoked population spikes in isolated rat CA1 hippocampal slices in an in vitro model of seizure-like activity (EC50 = 0.03-0.08 µM)
Cayman Chemical CarbostyrIl 124 100mg
A chromphore; has been used as a building block in the synthesis of luminescent lanthanide complexes
Cayman Chemical ClInofIbrate 50mg
A hypolipidemic agent; inhibits HMG-CoA reductase (IC50 = 0.47 mM); stimulates the S-indan-1-ol dehydrogenase activity of human liver AKR 1C4; reduces serum cholesterol and triglyceride levels in rats fed a normal chow pellet diet or a semisynthetic diet containing sucrose as the only carbohydrate source at 10 and 30 mg/kg
Cayman Chemical DehydroascorbIc AcId 100mg
An oxidized form of ascorbic acid; inhibits hydrogen peroxide-induced cell death in murine astrocytes by approximately 74 and 83% at 0.5 and 1 mM, respectively; increases GPX and glutathione reductase activity and inhibits ROS production in hydrogen peroxide-treated astrocytes at 1 mM; increases cerebral blood flow and reduces infarct volume and mortality in a mouse model of cerebral ischemia-reperfusion injury induced by transient MCAO when administered prior to ischemia at 40 and 250 mg/kg; reduces infarct volume in a permanent MCAO mouse model when administered pre- or post-ischemia at 250 and 500 mg/kg, respectively
Cayman Chemical NolatrexedhydrochlorIde 100mg
A thymidylate synthase inhibitor (Ki = 11 nM); inhibits cell growth in a panel of human and murine cancer cell lines (IC50s = 0.39-6.6 μM); inhibits the growth of L1210 cells, an effect that is decreased by greater than 50-fold by the addition of exogenous thymidine; induces cell cycle arrest at the S phase in L1210 cells at 0.7 and 3.5 μM; increases life span in a thymidine kinase-deficient L5178Y/TK- murine lymphoma model at 25-200 mg/kg
Cayman Chemical Docosahexaenoyl GlycIn 50mg
Consists of docosahexaenoic acid, an ω-3 PUFA, with glycine attached at its carboxy terminus
Cayman Chemical Pperaqun 50mg
An antimalarial agent; a bis-quinoline compound; inhibits the ex vivo growth of P. falciparum isolates from malaria-infected patients (IC50s = 11.8-217.3 nM)
Cayman Chemical AzoxystrobIn 100mg
A broad-spectrum fungicide (LC95s = 20 = 2.9 µM); disrupts mRNA expression of antioxidant-, stress response-, and innate immune-related genes and induces the production of ROS in zebrafish larva at 0.1-100 UG/L; inhibits proliferation of KYSE-150 human esophageal squamous cell carcinoma cells (IC50 = 2.42 UG/ml after 48 hours); reduces tumor growth at 40 mg/kg per day
Cayman Chemical BenocyclIdIn 50mg
A derivative of phencyclidine that acts as a potent and selective dopamine reuptake inhibitor (IC50 = 8 nM); intended for forensic and research applications