Sera
Cayman Chemical AfatInIbmaleate 100mg
An inhibitor of EGFR and ErbB2 (IC50s = 0.5 and 14 nM, respectively); increases the cytotoxicity of adriamycin in a concentration-dependent manner in multidrug-resistant A549T lung cancer cells overexpressing P-glycoprotein; reduces tumor growth in ErbB2-amplified NCI-N87 and NUGC4 gastric cancer mouse xenograft models at 20 mg/kg
Cayman Chemical Etofenamate 50mg
An NSAID and diethylene glycol ester form of flufenamic acid; inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and production of PGE2 in stimulated rat peritoneal macrophages; reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively; inhibits inflammation in a rat model of adjuvant-induced arthritis; decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity
Cayman Chemical Terbutaln 50mg
A β2-adrenergic receptor agonist; an active metabolite of bambuterol; binds to β1-, β2-, and β3-ARs (Ki = 31.3, 15.4, and 79.8 nM, respectively); selectively increases adenylyl cyclase activity in CHO cell membranes expressing recombinant human β2- or β3- over β1-ARs at concentrations 100-fold greater than the respective Ki values; inhibits airway obstruction induced by methacholine or LTD4 in anesthetized guinea pigs
Cayman Chemical LIgustrazInhydrochlorIde 100mg
A compound with diverse biological activities; inhibits hydrogen peroxide-induced decreases in cell viability and the levels of SOD and GPX and increases in ROS and MDA levels in HUVECs at 100 and 150 μg/ml;) inhibits PGE2 production induced by LPS and IFN-γ in primary rat glia at 50 and 100 μM; reduces infarct volume, cortical edema, and cortical PGE2 levels in a rat model of transient focal cerebral ischemia induced by common carotid artery and middle cerebral artery occlusion at 20 mg/kg; inhibits the proliferation of MG-63, Saos-2, and U2OS osteosarcoma cells (IC50s = 10.3, 24.7, and 54.7 mg/ml, respectively) in vitro; reduces tumor growth in an MG-63 mouse xenograft model at 100 mg/kg every other day
Cayman Chemical namInhydrochlorIde 100mg
A natural degradation product of neomycin; a common core molecule used in the synthesis of aminoglycoside antibiotics
Cayman Chemical 8-methylamino NAD sodium sa
A derivative of NAD+; has been used in the screening of analog-sensitive PARP1 gatekeeper mutations; has been used in the synthesis of cADPR derivatives
Cayman Chemical Ipragliflozin 100MG
A SGLT2 inhibitor (IC50 = 7.4 nM in CHO cells expressing the human cotransporter); selective for SGLT2 over SGLT1, SGLT3, SGLT4, SGLT5, and SGLT6 (IC50s = 1.9, 30.4, 15.9, 0.46, and 10.4 µM, respectively); decreases plasma levels of insulin and glucose in an oral glucose tolerance test in a mouse model of diabetes induced by high-fat diet, STZ, and nicotinamide from 0.1-3 mg/kg; decreases plasma and hepatic IL-6, TNF-α, CCL2, and CRP levels in the same model at 3 mg/kg per day for 28 days
Cayman Chemical socorydn 50mg
An aporphine alkaloid; reduces the action potential duration and amplitude in isolated canine Purkinje fibers at 100 µM; induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips (EC50 = 12.6 µM); cytotoxic to A549 lung cancer cells (IC50 = 197.73 µM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 UG/ml, respectively); reduces tumor growth in a Huh7 mouse xenograft model when used in combination with doxorubicin
Cayman Chemical StramustIn PhosphatSodIu 100mg
A derivative of estradiol that destabilizes microtubules (Kds = 10 and 15 µM for MAP-1 and MAP-2, respectively); induces cell cycle arrest in mitosis at the metaphase stage in DU145 and PC3 prostate cancer cells; induces apoptosis in U87MG human malignant glioma cells
Cayman Chemical CefonIcIdodIum salt 100mg
A broad-spectrum antibiotic with a prolonged serum elimination half-life in animals
Cayman Chemical HexacosnoIc AcId 100mg
A 26-carbon saturated fatty acid; plasma levels are increased in a mouse model of adrenoleukodystrophy; increased levels in red blood cells or in plasma positively correlated with atherosclerotic risk factors and metabolic syndrome, respectively
Cayman Chemical Pralatrexate 50mg
A DHFR inhibitor (Ki = 13.4 pM) and antifolate; inhibits growth of acute lymphocytic leukemia cells (IC50 = 0.04 μM), MDA-468, SK-BR-3, and ZR-75-1 breast cancer cells (IC50s = 0.11, 0.28, and 0.26 μM, respectively), and SK-LC8 and SK-LC16 NSCLC cells (IC50s = 0.42 and 0.11 μM, respectively); increases median survival in vivo in an H9 T cell lymphoma mouse xenograft model
Cayman Chemical UDPD-GlucosesodIum salt 100mg
A nucleotide sugar and P2Y14 receptor agonist; induces inositol phosphate production in COS-7 cells expressing the human P2Y14 receptor (EC50 = 0.588 µM)