Sera
Cayman Chemical GunabenzhydrochlorIde 50mg
An α2-adrenergic receptor agonist (effective concentrations 10-100 nM) with hypotensive effects; competes for imidazoline I2-binding sites in brown adipose tissue (Ki = 97 nM)
Cayman Chemical OxcarbazepIn 50mg
A prodrug form of 10,11-dihydro-10-hydroxy carbamazepine; inhibits high-frequency repetitive firing of rat spinal cord neurons at 1 µM; protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20 mg/kg), as well as PTZ- or picrotoxin-induced seizures in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively)
Cayman Chemical VU0134992hydrochlorIde 50mg
An inhibitor of Kir4.1 (IC50 = 5.2 µM in a thallium flux assay); selective for Kir4.1 over Kir2.3, Kir7.1, and SUR1/Kir6.2 (IC50s = 13.2, 34.2, and 11.4 µM, respectively), as well as Kir1.1, Kir2.1, and Kir2.2 at 30 µM; inhibits Kir4.2, heteromeric GIRK1/GIRK2, and heteromeric GIRK1/GIRK4 (IC50s = 8.1, 2.5, and 3.1 µM, respectively); reduces polymyxin B-induced decreases in cell viability in HK-2 cells and prevents polymyxin B-induced increases in apoptosis in mouse embryonic kidney explant cultures at 5 µM; increases urine volume and urinary sodium and potassium levels in rats at 50 and 100 mg/kg
Cayman Chemical GunosIn 5trIphosphATso 100mg
A substrate for the synthesis of RNA during the transcription process and the synthesis of DNA during DNA replication; participates in G-protein-related signal transduction where it is converted to GDP through the action of GTPases
Cayman Chemical OxotremorIn MIodIde 50mg
A muscarinic acetylcholine receptor agonist and KCNQ2/3 potassium channel blocker; induces phosphoinositide hydrolysis in mouse ileum isolated from wild-type, M2, M3 and M2/M3 knockout mice (EC50s = 0.36, 0.52, 1.62, and 1.48 μM, respectively); increases M4-induced inhibition of calcium currents in NG108-15 mouse neuroblastoma X rat glioma hybrid cells (EC50 = 0.14 μM); inhibits KCNQ2/3 potassium currents in Xenopus oocytes expressing M1 receptors and KCNQ2/3 potassium channels (IC50 = 1.1 μM); decreases KCNQ2/3 potassium currents in Xenopus oocytes lacking muscarinic receptors in a dose-dependent manner
Cayman Chemical TAS 103hydrochlorIde 50mg
A DNA topoisomerase I and II inhibitor (IC50s = 2 and 6.5 µM, respectively); stabilizes topoisomerase I-DNA and topoisomerase II-DNA cleavable complexes in KB cells at 3 µM; cytotoxic to P388 and KB cells (IC50s = 1.1 and 9.6 nM, respectively); reduces pulmonary metastasis in murine B16-BL6 melanoma and UV-2237M fibrosarcoma models of lung metastasis at 15, 26, and 45 mg/kg per day; reduces tumor growth in a variety of human cancer mouse xenograft models
Cayman Chemical A2764hydrochlorIde 50mg
An inhibitor of K2P18.1/TRESK (IC50 = 11.8 µM in ionomycin-stimulated Xenopus oocytes expressing the mouse receptor); selective for K2P18.1/TRESK over K2P2.1/TREK1, K2P10.1/TREK2, K2P4.1/TRAAK, K2P3.1/TASK1, K2P3.2/TASK2, K2P3.3/TASK3, K2P16.1/TALK1, and K2P13.1/THIK1 at 100 µM; inhibits basal potassium currents in isolated mouse dorsal root ganglion neurons at 100 µM
Cayman Chemical SureLIghtAlophycocynInA 50mg
Immunogen Synthetic peptide from the C-terminal region of human eNOS Host Rabbit Species Reactivity ( ) bovine and human Cross Reactivity (−) iNOS and nNOS Application WB
Cayman Chemical SureLIghtAlophycocynInA 100mg
An estrogen metabolite that acts as a substrate of MRP2 (Km 75 UM) and through MRP2-mediated transport functions as a cholestatic agent decreasing bile flow
GOLDEN WEST DIAGNOSTICS GOLD HUM SERUM,MMA FREE,100ML
Mass Spect Gold Human Serum, MMA Free1 x 100ml
