Human Sera
Cayman Chemical AdefovIr dIpIvoxIl 100mg
A prodrug form of adefovir; inhibits HBV DNA synthesis in HepG2 2.2.15 cells infected with HBV (EC50 = 0.517 μM); cytotoxic to HepG2 2.2.15 cells (CC50 = 540 μM); inhibits HBV replication in the liver of HBV transgenic mice (ED50 = 0.2 μmol/kg per day)
Cayman Chemical Gncclovr 50mg
An active metabolite of valganciclovir and an antiviral nucleoside derivative; reduces human, monkey, mouse, and guinea pig CMV replication in plaque reduction assays (EC50s = 1.3-70 µM); topical application decreases disease severity and corneal leukocyte infiltration in a cat model of ocular FHV-1 epithelial infection at 0.15%; prevents allograft histologic injury and NK and myeloid cell infiltration in a mouse model of murine CMV infection with renal transplantation at 15 mg/kg; induces tumor regression in a K-BALB murine sarcoma model using a mixed population of HSV TK positive or negative cells
Cayman Chemical CefmenoxImehydrochlorIde 50mg
A cephalosporin antibiotic; active against clinical isolates of S. aureus, S. epidermidis, S. pyogenes, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. marcescens, and E. cloacae in vitro (MICs = 0.013-6.25 μg/ml); active against various Gram-positive and Gram-negative bacterial infections in mice (ED50s = 0.016-66 mg/kg); increases survival in a mouse model of K. pneumoniae infection (SD50 = 7.6 mg/kg); curative in a mouse model of P. mirabilis urinary tract infection (CD50s = 0.4-0.75 mg/kg)
Cayman Chemical 2-BFIhydrochlorIde 50mg
An imidazoline I2 receptor agonist; selectively binds to the imidazoline I2 receptor over α2-ARs in rabbit whole brain membranes (Kis = 0.0013 and 3.736 µM, respectively), as well as the imidazoline I1 receptor in human platelet membranes (Kis = 0.0667 and 53 µM for the high- and low-affinity sites, respectively); reduces immobility time in the tail suspension test at 100 µmol/kg, an effect that can be reversed by idazoxan, methysergide, or haloperidol; intracerebroventricular administration enhances morphine-induced antinociception in the tail-flick test in mice at 10 UG/animal; improves neurological deficits, reduces brain edema, microglia activation, and neutrophil infiltration, and inhibits neuronal necrosis in a rat model of traumatic brain injury
Cayman Chemical Valeroyl SalIcylate 50mg
Valeroyl salicylate is a selective, irreversible inhibitor of COX-1. The IC50 values for ovine COX-1 and -2 are 0.8 mM and 15 mM, respectively.{1364} The half-lives for inactivation of human recombinant and ovine COX-1 in the presence of 500 µM valeroyl salicylate are 12 and 45 minutes, respectively.{1284,1364}
Cayman Chemical SB-224289hydrochlorIde 50mg
A potent 5-HT1B inverse agonist (pKi = 8.16) that displays >75-fold selectivity for human 5-HT1B over all other 5-HT receptors
Cayman Chemical 1R 3R3Hydroxycyclopentn 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical 3-O-MethylgunosIn 100mg
An antiviral nucleoside analog; inhibits viral plaque formation and viral RNA synthesis in vaccinia virus-infected Vero cells at 10 µM
Cayman Chemical DehydrolIthocholIc AcId 100mg
A major metabolite of lithocholic acid; formed from LCA by CYP3A4; an agonist of TGR5 (EC50 = 0.27 μM), VDR (EC50 = 3 μM), and FXR in cell-based reporter assays; binds to human PXR (IC50 = 15 μM) and activates mouse and human PXRs in cell-based reporter assays at 100 μM; binds to RORγt (Kd = 1.13 μM for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay at 10 μM; inhibits the differentiation of TH17 cells at 20 μM
Cayman Chemical ArtIcaInhydrochlorIde 50mg
An amide local anesthetic most commonly used in dentistry; it possesses a unique ester side chain that is metabolized rapidly by circulating esterases
Cayman Chemical Cycloastragenol 100mg
A telomerase activator that can slow telomere loss, increase replicative capacity, and improve immune function in CD8+ T lymphocytes from HIV-1-infected patients
Cayman Chemical PropylhexedrInhydrochLRId 50mg
An α-adrenergic sympathomimetic amine that acts as a local vasoconstrictor; intended for research and forensic applications
Cayman Chemical RepaglInIde 100mg
An ATP-dependent potassium channel blocker (Kd = 0.42 nM for the sulphonylurea receptor SUR1 when co-expressed with Kir6.2); lowers blood glucose in fasted rats and dogs (ED50s = 10 and 28.3 μg/kg, respectively)
Cayman Chemical TerazosInhydrochlorIde 100mg
A potent and selective α1-AR antagonist; selective for α1-AR (Kis = 3.28, 0.68, and 1.09 for α1A-, α1B- and α1D-ARs, respectively) over α2-AR subtypes (Kis = 1,510, 7.71, and 78.2 nM for A2a-, A2b-, and A2c-ARs, respectively); decreases blood pressure in spontaneously hypertensive rats when administered at 0.1-30 mg/kg