Primary Antibody Matched Pairs
Biotium CD55 (DAF)(F4-29D9), CF740 conjugate, 0.1mg/mL
Recognizes a single chain glycoprotein of 70 kDa, identified as CD55 (also known as decay accelerating factor, DAF). This MAb was clustered in Kobe at the Sixth International Workshop on Human Leukocyte Differentiation Antigens as F429D-9 (N-L120). CD55/DAF is widely expressed on cells throughout the body including leukocytes, erythrocytes, epithelium, endothelium, and fibroblasts. It is a Glycosyl phosphatidylinositol anchored (GPI-anchored) member of the membrane bound complement regulatory proteins that inhibit autologous complement cascade activation. It prevents the amplification steps of the complement cascade by interfering with the assembly of the C3-convertases, C4b2a and C3bBb, and the C5-convertase, C4b2a3b and C3bBb3b. CD55 also serves as receptor for CD97 and for echovirus and Coxsackie B virus. Anti-CD55 can be used as marker for paroxysmal nocturnal hemoglobinuria (PNH).Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and o
Biolegend Purified anti-human CD56 NCAM
Purified anti-human CD56 (NCAM) [W22098A]; Isotype: Mouse IgG2b, κ; Reactivity: Human; Apps: FC; Size: 100 μg
ABclonal Technology HLA-DRA Rabbit pAb
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Biotium Human Kappa Light Chain (B-Cell Marker) (IGKC/1999R), Biotin conjugate, 0.1mg/mL
This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give h
Meso Scale Discovery SPLEX HUM IL1B KitQP 25 PL
The S-PLEX Human IL-1 Kit from Meso Scale Discovery is a highly sensitive immunoassay that enables the simultaneous detection of IL-1 in human serum plasma and cell culture supernatants This multiplex assay utilizes MSD s proprietary SECTOR Imager and SULFO-TAG labels for electrochemiluminescent detection The kit includes a 96-well plate pre-coated with capture antibodies detection antibodies conjugated to ruthenium calibrators and reagents required to perform up to 25 tests in duplicate The assay has a sensitivity of 0 04 pg/mL and a broad dynamic range from 0 06 - 1500 pg/mL This kit allows for the rapid and accurate quantification of IL-1 levels in various human sample types
Meso Scale Discovery U-PLEX Human NGAL/LCN2 ASY
The Meso Scale Discovery U-PLEX Human NGAL (LCN2) Assay is an electrochemiluminescent immunoassay for the quantitative measurement of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in human serum plasma and urine This assay uses MSD s proprietary U-PLEX technology is highly sensitive has a broad dynamic range of 78 - 50 000 pg/mL and shows no cross-reactivity with other human proteins It requires a low sample volume of 50 L and provides results in under 3 hours This assay can aid in the early detection of acute kidney injury
Biotium Cathepsin D (Tumor Marker)(CTSD/3276), CF740 conjugate, 0.1mg/mL
Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blu
Biotium RAD51 (Prognostic and Response to Chemotherapy Marker)(RAD51/2753), 0.2mg/mL
RAD51 is one of the key factors of DNA repair by homologous recombination and has been shown to have anti-apoptotic activity in tumor cells. RAD51 protein interacts with a variety of tumor suppressor proteins including p53, BRCA1 and BRCA2. Elevated expression of RAD51 enhances radio-resistance of human tumor cells. Overexpression of RAD51 protein in tumor cells renders them resistant against cytotoxic drugs like Cisplatin. RAD51 interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of RAD51. High-level expression of RAD51 has been observed in a variety of human malignancies. RAD51 overexpression correlates with histological grading of the tumor in invasive ductal mammary carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightnes
Medchemexpress LLC Recombinant human aldo-keto reductase AKR1C2, His-tagged | >90.0% | 50 UG
Recombinant human AKR1C2 protein, His-tagged, expressed in E. coli and supplied lyophilized for research use. The enzyme reduces ketosteroids using NADH/NADPH and is characterized for activity, purity, and storage stability.
- Supplied as 50 μg lyophilized protein.
- N-terminal 6xHis tag for purification and detection.
- Expressed in E. coli expression system.
- Purity >90% by reducing SDS-PAGE.
- Approximate molecular weight 38 kDa.
- Specific activity 54.55 pmol/min/μg (S-1-indanol, NADP+).
- Lyophilized from 50 mM Tris-HCl, 300 mM NaCl, pH 7.4; store -20°C.
- After reconstitution, stable at 4°C for 1 week or -20°C for longer with carrier protein.
Biotium RAD51 (Prognostic and Response to Chemotherapy Marker)(RAD51/2765), 0.2mg/mL
RAD51 is one of the key factors of DNA repair by homologous recombination and has been shown to have anti-apoptotic activity in tumor cells. RAD51 protein interacts with a variety of tumor suppressor proteins including p53, BRCA1 and BRCA2. Elevated expression of RAD51 enhances radio-resistance of human tumor cells. Overexpression of RAD51 protein in tumor cells renders them resistant against cytotoxic drugs like Cisplatin. RAD51 interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of RAD51. High-level expression of RAD51 has been observed in a variety of human malignancies. RAD51 overexpression correlates with histological grading of the tumor in invasive ductal mammary carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightnes
ABclonal Technology CRYZ Rabbit pAb
Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist.
Biotium CD79b (B-Cell Marker) (IGB/1844), CF568 conjugate, 0.1mg/mL
CD79 (also designated Ig α/Igβ) is a heterodimer composed of α chains, designated CD79A or MB-1, andβ chains, designated CD79B or B29. The B cell antigen receptor complex (BCR) is formed by the association of CD79 with a membrane immunoglobulin, such as IgM or IgD. The membrane immunoglobulins IgM and IgD achieve surface expression and antigen presentation function in response to CD79 association. The cytoplasmic tails of both CD79A and CD79B contain an ITAM (immuno-receptor tyrosine-based activation) motif, which acts to initiate the BCR signaling reactions by binding to and activating tyrosine kinases.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-spe
Medchemexpress LLC S100A9 Human His 10ug
S100A9 Protein, Human (His) is a recombinant fragment of the human S100A9 calcium-binding protein supplied lyophilized for research use. The protein contains an N-terminal 6xHis affinity tag, is expressed in Escherichia coli, and is provided with recommended formulation and storage guidance for biochemical and immunological assays.
- Recombinant human S100A9 with N-terminal His tag.
- High purity (>95%) as determined by reducing SDS-PAGE.
- Supplied lyophilized with stabilizers to support storage.
- Suitable for biochemical and immunological research applications.
- Recommended reconstitution at 100 μg/mL or higher and aliquot storage at -20°C/-80°C.
Biotium CD79b (B-Cell Marker)(B29/123), CF405S conjugate, 0.1mg/mL
CD79 (also designated Ig chains, designated CD79B or B29. The B cell antigen receptor complex (BCR) is formed by the association of CD79 with a membrane immunoglobulin, such as IgM or IgD. The membrane immunoglobulins IgM and IgD achieve surface expression and antigen presentation function in response to CD79 association. The cytoplasmic tails of both CD79A and CD79B contain an ITAM (immuno-receptor tyrosine-based activation) motif, which acts to initiate the BCR signaling reactions by binding to and activating tyrosine kinases. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Biotium CD79b (B-Cell Marker)(IGB/2940R), CF594 conjugate, 0.1mg/mL
CD79 (also designated Ig chains, designated CD79B or B29. The B cell antigen receptor complex (BCR) is formed by the association of CD79 with a membrane immunoglobulin, such as IgM or IgD. The membrane immunoglobulins IgM and IgD achieve surface expression and antigen presentation function in response to CD79 association. The cytoplasmic tails of both CD79A and CD79B contain an ITAM (immuno-receptor tyrosine-based activation) motif, which acts to initiate the BCR signaling reactions by binding to and activating tyrosine kinases. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.