Cayman Chemical ANTIBODY H3B-8800 500ug
An inhibitor of the SF3B complex; binds to SF3B complexes containing wild-type SF3B (IC50 = 1.4 nM) or various SF3B mutations (IC50s = 0.3-1.8 nM); inhibits SF3B1-induced splicing of canonical and aberrant pre-mRNA junctions in HEK293T nuclear extracts overexpressing SF3B1K700E; selectively inhibits the growth of, and induces apoptosis in, Panc 05.04 pancreatic cancer cells expressing mutant SF3B over Panc 10.05, HAPF-II, and CFPAC-1 pancreatic cancer cells expressing wild-type SF3B in a concentration-dependent manner; reduces tumor growth in a K562 mouse xenograft model using K562 cells expressing wild-type SF3B1 at 8 mg/kg and K562 cells expressing SF3B1K700E at 2, 4, or 8 mg/kg