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Secondary antibodies where hamster is the host species. Secondary antibodies must be raised against the host species of the primary antibody. Includes different antigens, classifications, conjugations, and isotypes.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated to the dye under optimum conditions and unreacted dye was removed.
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The protein encoded by this gene is essential for T-cell proliferation and survival cytokine production and T-helper type-2 development Several alternatively spliced transcript variants encoding different isoforms have been found for this gene
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Enables protein kinase binding activity Acts upstream of or within several processes including positive regulation of immune response positive regulation of intracellular signal transduction and regulation of lymphocyte activation Located in external side of plasma membrane and immunological synapse Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus Orthologous to human CD28 (CD28 molecule)
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CD28 Protein activates T-cells promoting cell proliferation cytokine production and T-cell survival It collaborates with TCR/CD3 ligation and CD40L costimulation to boost IL4 and IL10 production in T-cells CD28 Protein forms a disulfide-linked homodimer and interacts with DUSP14 It also binds to CD80/B7-1 and CD86/B7-2/B70 and interacts with GRB2 (By similarity) CD28 Protein Rat (HEK293 His) is the recombinant rat-derived CD28 protein expressed by HEK293 with C-His labeled tag
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Anti-Mouse CD28 In Vivo Antibody - Low Endotoxin is a in vivo antibody with mouse reactivity produced in syrian hamster Available in 100 mg size with 7 - 14 business days lead time Ships via gel pack Functional grade preclinical antibodies may be stored sterile as received at 2-8 C for up to one month For longer term storage aseptically aliquot in working volumes without diluting and store at -80 C Avoid Repeated Freeze Thaw Cycles
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Enables protein kinase binding activity Acts upstream of or within several processes including positive regulation of immune response positive regulation of intracellular signal transduction and regulation of lymphocyte activation Located in external side of plasma membrane and immunological synapse Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus Orthologous to human CD28 (CD28 molecule)
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Recognizes a glycoprotein of 44-88 kDa which is identified as CD28 It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells Besides its co-stimulation role CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death CD28 is also expressed on human fetal NK cells and some NK cell lines whereas on murine NK cells the CD28 expression is much broader Primary antibodies are available purified or with a selection of fluorescent CF Dyes and other labels CF Dyes offer exceptional brightness and photostability Note Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors
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