Hamster Secondary Antibodies
Hamster Secondary Antibodies
ICOS (CD278) Armenian Hamster anti-Human, Mouse, Alexa Fluor™ 488, Clone: C398.4A, BD Phrmingen™
Armenian Hamster Monoclonal Antibody
Biotang Inc CD28, Hamster Anti-Mouse, FITC, CD28 Antibody, FITC, Clone NYRmCD28. Type Hamster Anti Mouse Monoclonal.
CD28, Hamster Anti-Mouse, FITC, CD28 Antibody, FITC, Clone NYRmCD28. Type Hamster Anti Mouse Monoclonal.
Biotang Inc CD28, Hamster Anti-Mouse, CD28 Antibody, Type Hamster Anti Mouse Monoclonal. Clone NYRmCD28.
CD28, Hamster Anti-Mouse, CD28 Antibody, Type Hamster Anti Mouse Monoclonal. Clone NYRmCD28.
Genscript Corporation CD28 Fc Chimera, Human
Human CD28 is composed of four exons encoding a protein of 220 amino acids that is expressed on the cell surface as a glycosylated, disulfide-linked homodimer of 44 kDa. Members of the CD28 family share a number of common features. These receptors consist of paired V-set immunoglobulin superfamily (IgSF) domains attached to single transmembrane domains and cytoplasmic domains that contain critical signaling motifs. The CD28 and CTLA4 ligands, CD80 and CD86, consist of single V-set and C1-set IgSF domains. The interaction of these costimulatory receptors with ligands is mediated through the MYPPPY motif within the receptor V-set domains. CD28 is expressed constitutively on almost all human CD4 T cells and approximately 50% of CD8 T cells. CD28 costimulation has diverse effects on T cell function, including biochemical events at the immunological synapse, downstream phosphorylation and other post-translational modifications, transcriptional changes, and cytoskeletal remodeling.
AdipoGen CD152 hrecuntagged
Recombinant protein. Human CD152 aa 36-161 is untagged. Binds to human CD80. Source HEK 293 cells. Lyophilized. Contains PBS. CD152 Cytotoxic T-lymphocyte-associated protein 4 CTLA-4 is an inhibitory receptor belonging to the CD28 immunoglobulin subfamily, expressed primarily by T cells. Its ligands, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4, resulting in a costimulatory or a co-inhibitory response, respectively. Because of its dampening effect, CTLA-4 is a crucial regulator of T cell homeostasis and self-tolerance. While CD28 promotes T cell activation and proliferation, CTLA-4 is reported to dampen T cell responses through a variety of mechanisms. Prior to activation, conventional T cells Tconv express low levels of CTLA-4, predominantly in intracellular compartments. Upon activation, CTLA-4 expression is upregulated and becomes increasingly detectable on the cell surface.