Rabbit Secondary Antibodies
ABclonal Technology 594 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology 647 Rabbit anti-Human GP6/GPVI
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11) Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene
ABclonal Technology 647 Rabbit anti-Human IgE
IgE is the class of antibodies produced in the lungs skin and mucous membranes It may protect against parasite invasion but it is a major factor in allergic reactions The antigen-specific IgE interacts with mast cells and eosinophils triggers the release of histamine leukotrienes and other substances that lead to the itching sneezing and congestion of allergies - and the life threatening respiratory distress of asthma and anaphylactic shock
ABclonal Technology 647 Rabbit anti-Human CDCP1
This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis Alternative splicing results in multiple transcript variants of this gene
ABclonal Technology 647 Rabbit anti-Human CD45RA
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 594 Rabbit anti-Human CD68
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages It is a member of the lysosomal endosomal-associated membrane glycoprotein (LAMP) family The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins The protein is also a member of the scavenger receptor family Scavenger receptors typically function to clear cellular debris promote phagocytosis and mediate the recruitment and activation of macrophages Alternative splicing results in multiple transcripts encoding different isoforms
ABclonal Technology PE Rabbit anti-Human IL-5 mAb
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils The encoded cytokine plays a major role in the regulation of eosinophil formation maturation recruitment and survival The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases This cytokine functions by binding to its receptor which is a heterodimer whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2 GM-CSF) This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4) interleukin 13 (IL13) and CSF2 This gene IL4 and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31
ABclonal Technology 610 Rabbit anti-Human EGFR
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily This protein is a receptor for members of the epidermal growth factor family EGFR is a cell surface protein that binds to epidermal growth factor thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation Mutations in this gene are associated with lung cancer EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
ABclonal Technology 450 Rabbit anti-Human CD97
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors which mediate cell-cell interactions These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit which associate at the cell surface as a receptor complex The encoded protein may play a role in cell adhesion as well as leukocyte recruitment activation and migration and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55 Expression of this gene may play a role in the progression of several types of cancer Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19
Abcam Rabbit Anti-Human IgA alpha chain (HRP).
Rabbit Anti-Human IgA alpha chain (HRP).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Rabbit Anti-Human IgG2 H&L (Biotin).
Rabbit Anti-Human IgG2 H&L (Biotin).
The product is subject to the following: Abcam Restricted Use Statement
![Abcam Rabbit monoclonal [H26-10] Anti-Human IgG1 H&L (Biotin)](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1337791.JPG-250.jpg)
Abcam Rabbit monoclonal [H26-10] Anti-Human IgG1 H&L (Biotin)
Rabbit monoclonal [H26-10] Anti-Human IgG1 H&L (Biotin)
The product is subject to the following: Abcam Restricted Use Statement
Vector Laboratories IHC‑plus Polyclonal Rabbit anti‑Human LIMPII / SCARB2 Antibody IHC IF WB LS‑B3225
IHC‑plus Polyclonal Rabbit anti‑Human LIMPII / SCARB2 Antibody IHC IF WB LS‑B3225
ABclonal Technology 594 Rabbit anti-Human MMP9
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development reproduction and tissue remodeling as well as in disease processes such as arthritis and metastasis Most MMP s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases The enzyme encoded by this gene degrades type IV and V collagens Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow and murine studies suggest a role in tumor-associated tissue remodeling
ABclonal Technology 488 Rabbit anti-Human TNF-a
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily This cytokine is mainly secreted by macrophages It can bind to and thus functions through its receptors TNFRSF1A TNFR1 and TNFRSF1B TNFBR This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation differentiation apoptosis lipid metabolism and coagulation This cytokine has been implicated in a variety of diseases including autoimmune diseases insulin resistance psoriasis rheumatoid arthritis ankylosing spondylitis tuberculosis autosomal dominant polycystic kidney disease and cancer Mutations in this gene affect susceptibility to cerebral malaria septic shock and Alzheimer disease Knockout studies in mice also suggested the neuroprotective function of this cytokine