Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Human CPT1A mAb
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable) together with a carnitine-acylcarnitine translocase CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 450 Rabbit anti-Human CD142
This gene encodes coagulation factor III a cell surface glycoprotein that initiates blood coagulation by acting as a high-affinity receptor for factor VII The resulting complex triggers protease cascades via limited proteolysis Unlike other circulating cofactors factor III is fully active when expressed on cell surfaces such as monocytes It has three domains extracellular transmembrane and cytoplasmic Its expression is induced by procoagulatory and proinflammatory stimuli and is implicated in HIV-associated coagulopathy and COVID-19 severity Notably no congenital deficiency has been identified Multiple transcript variants arise from alternative splicing
ABclonal Technology 594 Rabbit anti-Human CD200R
This gene encodes a receptor for the OX-2 membrane glycoprotein Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner Alternative splicing of this gene results in multiple transcript variants
ABclonal Technology 488 Rabbit anti-Human CD48
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins The encoded protein is found on the surface of lymphocytes and other immune cells dendritic cells and endothelial cells and participates in activation and differentiation pathways in these cells The encoded protein does not have a transmembrane domain however but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor Multiple transcript variants encoding different isoforms have been found for this gene
Jackson Immuno Research Labs Cy3-AffiniPure Rabbit Anti-Human IgG Fcγ Fragment Specific
Cy3-AffiniPure Rabbit Anti-Human IgG Fcγ Fragment Specific
ABclonal Technology 647 Rabbit anti-Human IL23R
The protein encoded by this gene is a subunit of the receptor for IL23A IL23 This protein pairs with the receptor molecule IL12RB1 IL12Rbeta1 and both are required for IL23A signaling This protein associates constitutively with Janus kinase 2 (JAK2) and also binds to transcription activator STAT3 in a ligand-dependent manner
Jackson Immuno Research Labs Alexa Fluor 647-AffiniPure Rabbit Anti-Human Serum IgA α Chain Specific
Alexa Fluor 647-AffiniPure Rabbit Anti-Human Serum IgA α Chain Specific
ABclonal Technology 488 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983]) [supplied by OMIM May 2010]
ABclonal Technology 610 Rabbit anti-Human CD94
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation Several genes of the C-type lectin superfamily including members of the NKG2 family are expressed by NK cells and may be involved in the regulation of NK cell function KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus Several transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-Human CD1c
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail Alternatively spliced transcript variants of this gene have been observed but their full-length nature is not known
ABclonal Technology 488 Rabbit anti-Human BCL6
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain This protein acts as a sequence-specific repressor of transcription and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) and may be involved in the pathogenesis of DLCL Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene
ABclonal Technology 450 Rabbit anti-Human EGFR
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily This protein is a receptor for members of the epidermal growth factor family EGFR is a cell surface protein that binds to epidermal growth factor thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation Mutations in this gene are associated with lung cancer EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
ABclonal Technology 594 Rabbit anti-Human IL-1B
The protein encoded by this gene is a member of the interleukin 1 cytokine family This cytokine is produced by activated macrophages as a proprotein which is proteolytically processed to its active form by caspase 1 (CASP1 ICE) This cytokine is an important mediator of the inflammatory response and is involved in a variety of cellular activities including cell proliferation differentiation and apoptosis The induction of cyclooxygenase-2 (PTGS2 COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2
ABclonal Technology PE Rabbit anti-Human CD138 mAb
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family The syndecans mediate cell binding cell signaling and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins Altered syndecan-1 expression has been detected in several different tumor types While several transcript variants may exist for this gene the full-length natures of only two have been described to date These two represent the major variants of this gene and encode the same protein
ABclonal Technology 488 Rabbit anti-Human SIGLEC9
Predicted to enable monosaccharide binding activity and sialic acid binding activity Predicted to be involved in cell adhesion Predicted to act upstream of or within negative regulation of inflammatory response and negative regulation of phagocytosis engulfment Predicted to be located in external side of plasma membrane Predicted to be active in plasma membrane