Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Human CD28 mAb
The protein encoded by this gene is essential for T-cell proliferation and survival cytokine production and T-helper type-2 development Several alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 610 Rabbit anti-Human CD89
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils monocytes macrophages and eosinophils where it mediates immunologic responses to pathogens It interacts with IgA-opsonized targets and triggers several immunologic defense processes including phagocytosis antibody-dependent cell-mediated cytotoxicity and stimulation of the release of inflammatory mediators Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene
ABclonal Technology 647 Rabbit anti-Human Ki67
Enables protein C-terminus binding activity Involved in regulation of chromosome segregation and regulation of mitotic nuclear division Located in chromosome nuclear body and nucleolus Colocalizes with condensed chromosome Implicated in Crohn s disease breast cancer human immunodeficiency virus infectious disease and pancreatic cancer Biomarker of several diseases including Barrett s esophagus autoimmune disease of musculoskeletal system (multiple) endocrine gland cancer (multiple) gastrointestinal system cancer (multiple) and interstitial cystitis
ABclonal Technology APC Rabbit anti-Human CD153
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family This cytokine is a ligand for TNFRSF8 CD30 which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch This cytokine was shown to enhance cell proliferation of some lymphoma cell lines while to induce cell death and reduce cell proliferation of other lymphoma cell lines The pleiotropic biologic activities of this cytokine on different CD30 lymphoma cell lines may play a pathophysiologic role in Hodgkin s and some non-Hodgkin s lymphomas Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Human IL-2 mAb
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4 IL7 IL9 IL15 IL21 erythropoietin and thrombopoietin The protein encoded by this gene is a secreted cytokine produced by activated CD4 and CD8 T lymphocytes that is important for the proliferation of T and B lymphocytes The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7 The expression of this gene in mature thymocytes is monoallelic which represents an unusual regulatory mode for controlling the precise expression of a single gene The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease which suggests an essential role of this gene in the immune response to antigenic stimuli
ABclonal Technology APC Rabbit anti-Human CD33 mAb
CD33 a type I transmembrane protein is a sialic acid-binding Ig-like lectin (Siglec-3) of the Ig superfamily and human CD33 binds preferentially to alpha-2 6-linked sialic acid Upon binding to its ligands CD33 transduces an inhibitory signaling through the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its intracellular domain inhibiting cellular function such as phagocytosis In addition CD33 is also involved in other processes such as adhesion Due to its exclusive expression on hematopoietic cells particularly the myeloid lineage and their progenitors CD33 has been actively pursued as a therapeutic target against acute myeloid leukemia (AML) CD33 may also be involved in Alzheimer s Disease
ABclonal Technology 450 Rabbit anti-Human LAMP2
The protein encoded by this gene is a member of a family of membrane glycoproteins This glycoprotein provides selectins with carbohydrate ligands It may play a role in tumor cell metastasis It may also function in the protection maintenance and adhesion of the lysosome Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins
ABclonal Technology 488 Rabbit anti-Human CD27
The protein encoded by this gene is a member of the TNF-receptor superfamily This receptor is required for generation and long-term maintenance of T cell immunity It binds to ligand CD70 and plays a key role in regulating B-cell activation and immunoglobulin synthesis This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8 JNK Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor CD27-binding protein (SIVA) a proapoptotic protein can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor
ABclonal Technology 488 Rabbit anti-Human CEACAM6
This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma This gene affects the sensitivity of tumor cells to adenovirus infection The protein encoded by this gene acts as a receptor for adherent-invasive E coli adhesion to the surface of ileal epithelial cells in patients with Crohn s disease This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19
ABclonal Technology 488 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983]) [supplied by OMIM May 2010]
Abcam Rabbit Anti-Human IgM mu chain (Biotin).
Rabbit Anti-Human IgM mu chain (Biotin).
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology 488 Rabbit anti-Human CD55
This gene encodes a glycoprotein involved in the regulation of the complement cascade Binding of the encoded protein to complement proteins accelerates their decay thereby disrupting the cascade and preventing damage to host cells Antigens present on this protein constitute the Cromer blood group system (CROM) Alternative splicing results in multiple transcript variants The predominant transcript variant encodes a membrane-bound protein but alternatively spliced transcripts may produce soluble proteins
ABclonal Technology 450 Rabbit anti-Human Ki67
Enables protein C-terminus binding activity Involved in regulation of chromosome segregation and regulation of mitotic nuclear division Located in chromosome nuclear body and nucleolus Colocalizes with condensed chromosome Implicated in Crohn s disease breast cancer human immunodeficiency virus infectious disease and pancreatic cancer Biomarker of several diseases including Barrett s esophagus autoimmune disease of musculoskeletal system (multiple) endocrine gland cancer (multiple) gastrointestinal system cancer (multiple) and interstitial cystitis
ABclonal Technology 488 Rabbit anti-Human PTH1R
The protein encoded by this gene is a member of the G-protein coupled receptor family 2 This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH) The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system Defects in this receptor are known to be the cause of Jansen s metaphyseal chondrodysplasia (JMC) chondrodysplasia Blomstrand type (BOCD) as well as enchodromatosis Two transcript variants encoding the same protein have been found for this gene
ABclonal Technology PE Rabbit anti-Human CD24 mAb
This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface This gene was missing from previous genome assemblies but is properly located on chromosome 6 Non-transcribed pseudogenes have been designated on chromosomes 1 15 20 and Y Alternative splicing results in multiple transcript variants