Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Human CD8b mAb
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system The CD8 antigen acting as a coreceptor and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules The functional coreceptor is either a homodimer composed of two alpha chains or a heterodimer composed of one alpha and one beta chain Both alpha and beta chains share significant homology to immunoglobulin variable light chains This gene encodes the CD8 beta chain isoforms Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described A pseudogene also located on chromosome 2 has been identified
ABclonal Technology 488 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology 594 Rabbit anti-Human CD48
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins The encoded protein is found on the surface of lymphocytes and other immune cells dendritic cells and endothelial cells and participates in activation and differentiation pathways in these cells The encoded protein does not have a transmembrane domain however but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor Multiple transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 594 Rabbit anti-Human CD61
The ITGB3 protein product is the integrin beta chain beta 3 Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain A given chain may combine with multiple partners resulting in different integrins Integrin beta 3 is found along with the alpha IIb chain in platelets Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling
Medchemexpress LLC Rabbit Anti-Human Ig 100uL | 100uL
Rabbit Anti-Human IgG H L (HRP) is a horseradish peroxidase (HRP) labeled and Rabbit-derived polyclonal antibody which served as the secondary antibody
ABclonal Technology 647 Rabbit anti-Human CD33
CD33 a type I transmembrane protein is a sialic acid-binding Ig-like lectin (Siglec-3) of the Ig superfamily and human CD33 binds preferentially to alpha-2 6-linked sialic acid Upon binding to its ligands CD33 transduces an inhibitory signaling through the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its intracellular domain inhibiting cellular function such as phagocytosis In addition CD33 is also involved in other processes such as adhesion Due to its exclusive expression on hematopoietic cells particularly the myeloid lineage and their progenitors CD33 has been actively pursued as a therapeutic target against acute myeloid leukemia (AML) CD33 may also be involved in Alzheimer s Disease
ABclonal Technology 488 Rabbit anti-Human TROP-2
This intronless gene encodes a carcinoma-associated antigen This antigen is a cell surface receptor that transduces calcium signals Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy
ABclonal Technology 488 Rabbit anti-Human CD161
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation Several genes of the C-type lectin superfamily including the rodent NKRP1 family of glycoproteins are expressed by NK cells and may be involved in the regulation of NK cell function The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins a transmembrane domain and a cytoplasmic domain The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus
ABclonal Technology PE Rabbit anti-Human CD86 mAb
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily This protein is expressed by antigen-presenting cells and it is the ligand for two proteins at the cell surface of T cells CD28 antigen and cytotoxic T-lymphocyte-associated protein 4 Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response Alternative splicing results in several transcript variants encoding different isoforms
Jackson Immuno Research Labs Alexa Fluor 488-AffiniPure F(ab')2 Fragment Rabbit Anti-Human IgG Fcγ Fragment Specific
Alexa Fluor 488-AffiniPure F(ab')2 Fragment Rabbit Anti-Human IgG Fcγ Fragment Specific
ABclonal Technology 647 Rabbit anti-Human TrkA
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family This kinase is a membrane-bound receptor that upon neurotrophin binding phosphorylates itself and members of the MAPK pathway The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes Mutations in this gene have been associated with congenital insensitivity to pain anhidrosis self-mutilating behavior mental retardation and cancer Alternate transcriptional splice variants of this gene have been found but only three have been characterized to date
ABclonal Technology 594 Rabbit anti-Human CDA
This gene encodes an enzyme involved in pyrimidine salvaging The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine respectively It is one of several deaminases responsible for maintaining the cellular pyrimidine pool Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias
ABclonal Technology 647 Rabbit anti-Human IgA1
Ig alpha is the major immunoglobulin class in body secretions It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system In normal adult serum the approximate percentage composition of IgA with respect to is subclasses is IgA1 90% and IgA2 10% In secretory IgA the subclass proportions may approach 50 50 The clinical significance of the subclasses has yet to be determined
ABclonal Technology 647 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])