Rabbit Secondary Antibodies
ABclonal Technology 647 Rabbit anti-Human CD45RA
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 488 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology Biotin Rabbit anti-Human CD40
This gene belongs to the TNF-receptor superfamily and encodes a receptor on antigen-presenting cells crucial for mediating immune and inflammatory responses including T cell-dependent immunoglobulin class switching memory B cell development and germinal center formation The AT-hook transcription factor AKNA regulates both the receptor and its ligand important for homotypic cell interactions Adaptor protein TNFR2 mediates signal transduction by interacting with the receptor The receptor-ligand interaction is necessary for amyloid-beta-induced microglial activation playing a role in Alzheimer s disease Mutations in this gene cause autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) Multiple alternatively spliced transcript variants encode distinct isoforms
ABclonal Technology 594 Rabbit anti-Human MMP9
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development reproduction and tissue remodeling as well as in disease processes such as arthritis and metastasis Most MMP s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases The enzyme encoded by this gene degrades type IV and V collagens Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow and murine studies suggest a role in tumor-associated tissue remodeling
ABclonal Technology 647 Rabbit anti-Human Nectin-4
Nectin-4 poliovirus Receptor-like 4 (PVRL4) is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily that promotes intercellular adhesion by acting as a major component of adhesion junctions The extracellular domain of Nectin-4 consists of one Ig variable region (V) and two Ig constant regions (C) which mediate binding to measles virus and adjacent cells through trans-heterophile interactions with Nectin-1 Unlike other members of the connectin family which are widely expressed in adult tissues human Nectin-4 expression is largely limited to the blastoderm Studies have shown that Nectin-4 is overexpressed in cells from a variety of human solid tumors including pancreatic breast lung and ovarian cancers The expression pattern of Nectin-4 in normal tissues is limited so NECTIN-4 can be used as a novel therapeutic target for various human tumors
ABclonal Technology 647 Rabbit anti-Human CD142
This gene encodes coagulation factor III a cell surface glycoprotein essential for initiating blood coagulation It acts as a high-affinity receptor for factor VII forming a complex that triggers protease cascades via limited proteolysis Unlike other coagulation cofactors factor III is fully functional when expressed on cell surfaces such as on monocytes It has extracellular transmembrane and cytoplasmic domains Platelets and monocytes express this factor during procoagulatory and proinflammatory responses Factor III is implicated in HIV-related coagulopathy and is associated with COVID-19 severity and mortality Notably congenital deficiency of this protein has not been observed Multiple transcript variants exist due to alternative splicing
ABclonal Technology PE Rabbit anti-Human IgA1 mAb
Ig alpha is the major immunoglobulin class in body secretions It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system In normal adult serum the approximate percentage composition of IgA with respect to is subclasses is IgA1 90% and IgA2 10% In secretory IgA the subclass proportions may approach 50 50 The clinical significance of the subclasses has yet to be determined
ABclonal Technology 488 Rabbit anti-Human IL-17RB
The protein encoded by this gene is a cytokine receptor This receptor specifically binds to IL17B and IL17E but does not bind to IL17 and IL17C This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation which suggested the immunoregulatory activity of this receptor
ABclonal Technology PE Rabbit anti-Human TMPRSS2
This gene encodes a protein that belongs to the serine protease family The encoded protein contains a type II transmembrane domain a receptor class A domain a scavenger receptor cysteine-rich domain and a protease domain Serine proteases are known to be involved in many physiological and pathological processes This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E MERS-CoV SARS-CoV and SARS-CoV-2 (COVID-19 virus) Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Human FGFR3 mAb
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family with its amino acid sequence being highly conserved between members and among divergent species FGFR family members differ from one another in their ligand affinities and tissue distribution A full-length representative protein would consist of an extracellular region composed of three immunoglobulin-like domains a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain The extracellular portion of the protein interacts with fibroblast growth factors setting in motion a cascade of downstream signals ultimately influencing mitogenesis and differentiation This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia
ABclonal Technology 488 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology PE Rabbit anti-Human CD42b mAb
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer an alpha chain and a beta chain that is linked by disulfide bonds The Gp Ib functions as a receptor for von Willebrand factor (VWF) The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury and also initiates signaling events within the platelet that lead to enhanced platelet activation thrombosis and hemostasis This gene encodes the alpha subunit Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy
ABclonal Technology 647 Rabbit anti-Human CD6
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule The gene product is important for continuation of T cell activation This gene may be associated with susceptibility to multiple sclerosis (PMID 19525953 21849685) Multiple transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 450 Rabbit anti-Human CD45RA
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported