Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human CD7
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily This protein is found on thymocytes and mature T cells It plays an essential role in T-cell interactions and also in T-cell B-cell interaction during early lymphoid development
ABclonal Technology PE Rabbit anti-Human GPRC5D
The protein encoded by this gene is a member of the G protein-coupled receptor family however the specific function of this gene has not yet been determined
ABclonal Technology 450 Rabbit anti-Human IgD
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells where it is coexpressed with IgM The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases
ABclonal Technology PE Rabbit anti-Human MRC2 mAb
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer gliomas and metastatic bone disease
ABclonal Technology 594 Rabbit anti-Human CD204
This gene encodes class A macrophage scavenger receptors which include three isoforms (1 2 and 3) generated by alternative splicing These trimeric membrane glycoproteins are macrophage-specific and involved in various physiological and pathological processes such as atherosclerosis Alzheimer s and host defense Isoforms 1 and 2 are functional receptors that mediate endocytosis of modified low-density lipoproteins (LDLs) while isoform 3 despite containing the LDL-binding domain does not internalize modified LDL due to altered intracellular processing trapping it in the endoplasmic reticulum Isoform 3 can inhibit isoforms 1 and 2 when co-expressed suggesting a regulatory mechanism for scavenger receptor activity in macrophages
ABclonal Technology PE Rabbit anti-Human NT5E/CD73
The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides The encoded protein is used as a determinant of lymphocyte differentiation Defects in this gene can lead to the calcification of joints and arteries Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Human CD22 mAb
Predicted to enable CD4 receptor binding activity protein phosphatase binding activity and sialic acid binding activity Involved in B cell activation negative regulation of B cell receptor signaling pathway and regulation of endocytosis Located in early endosome and recycling endosome
ABclonal Technology 488 Rabbit anti-Human CD40
This gene belongs to the TNF-receptor superfamily and encodes a receptor on immune system antigen-presenting cells It mediates various immune and inflammatory responses including T cell-dependent immunoglobulin class switching memory B cell development and germinal center formation AKNA transcription factor regulates the receptor and its ligand important for homotypic cell interactions The adaptor protein TNFR2 mediates signal transduction The receptor-ligand interaction is essential for amyloid-beta-induced microglial activation potentially playing a role in Alzheimer s disease Mutations in this gene cause autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported
ABclonal Technology 647 Rabbit anti-Human CD40
This gene belongs to the TNF-receptor superfamily and encodes a receptor on immune system antigen-presenting cells It mediates various immune and inflammatory responses including T cell-dependent immunoglobulin class switching memory B cell development and germinal center formation AKNA transcription factor regulates the receptor and its ligand important for homotypic cell interactions The adaptor protein TNFR2 mediates signal transduction The receptor-ligand interaction is essential for amyloid-beta-induced microglial activation potentially playing a role in Alzheimer s disease Mutations in this gene cause autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported
ABclonal Technology 647 Rabbit anti-Human TIGIT
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH) The protein has been shown to bind PVR with high affinity this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses
ABclonal Technology PE Rabbit anti-Human CD22 mAb
Predicted to enable CD4 receptor binding activity protein phosphatase binding activity and sialic acid binding activity Involved in B cell activation negative regulation of B cell receptor signaling pathway and regulation of endocytosis Located in early endosome and recycling endosome
ABclonal Technology 488 Rabbit anti-Human CaSR
The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling and thus this protein plays an essential role in maintaining mineral ion homeostasis Mutations in this gene are a cause of familial hypocalciuric hypercalcemia neonatal severe hyperparathyroidism and autosomal dominant hypocalcemia
ABclonal Technology 488 Rabbit anti-Human IgA1
Ig alpha is the major immunoglobulin class in body secretions It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system In normal adult serum the approximate percentage composition of IgA with respect to is subclasses is IgA1 90% and IgA2 10% In secretory IgA the subclass proportions may approach 50 50 The clinical significance of the subclasses has yet to be determined
ABclonal Technology 647 Rabbit anti-Human CD35
Complement receptor type 1 (CR1 CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells neutrophils monocytes and renal podocytes As a component of the host s innate immune system CR1 CD35 expressed on neutrophils and monocytes binds to ligands coated with complement opsonins C3b and C4b thereby promoting phagocytosis and pro-inflammatory cytokine production CR1 CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of multiple cofactors for factor-I-mediated cleavage and inactivation of C3b and C4b
ABclonal Technology 647 Rabbit anti-Human CD51
The product of this gene belongs to the integrin alpha chain family Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit This subunit associates with beta 1 beta 3 beta 5 beta 6 and beta 8 subunits The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor This integrin may regulate angiogenesis and cancer progression Alternative splicing results in multiple transcript variants Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes