Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human CD30
The protein encoded by this gene is a member of the TNF-receptor superfamily This receptor is expressed by activated but not by resting T and B cells TRAF2 and TRAF5 can interact with this receptor and mediate the signal transduction that leads to the activation of NF-kappaB This receptor is a positive regulator of apoptosis and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported
ABclonal Technology 647 Rabbit anti-Human ERG
This gene encodes a member of the ETS family of transcription factors which regulate embryonic development cell proliferation differentiation angiogenesis inflammation and apoptosis The protein contains an ETS DNA-binding domain and a PNT domain involved in self-association of oncoproteins It is primarily expressed in the nucleus and plays a role in platelet adhesion to the subendothelium vascular remodeling hematopoiesis and megakaryocyte differentiation This gene is involved in chromosomal translocations leading to fusion proteins like TMPSSR2-ERG in prostate cancer EWS-ERG in Ewing s sarcoma and FUS-ERG in acute myeloid leukemia Over two dozen transcript variants have been reported though the full-length forms of many are undetermined
ABclonal Technology 488 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology PE Rabbit anti-Human CD74 mAb
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which when bound to the encoded protein initiates survival pathways and cell proliferation This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta) Multiple alternatively spliced transcript variants encoding different isoforms have been identified
ABclonal Technology 450 Rabbit anti-Human CD2
The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition A locus control region (LCR) has been found in the 3 flanking sequence of this gene
ABclonal Technology 450 Rabbit anti-Human CD2
The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition A locus control region (LCR) has been found in the 3 flanking sequence of this gene
ABclonal Technology 594 Rabbit anti-Human GP6/GPVI
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11) Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene
ABclonal Technology 488 Rabbit anti-Human IgE
IgE is the class of antibodies produced in the lungs skin and mucous membranes It may protect against parasite invasion but it is a major factor in allergic reactions The antigen-specific IgE interacts with mast cells and eosinophils triggers the release of histamine leukotrienes and other substances that lead to the itching sneezing and congestion of allergies - and the life threatening respiratory distress of asthma and anaphylactic shock
ABclonal Technology PE Rabbit anti-Human IgA1 mAb
Ig alpha is the major immunoglobulin class in body secretions It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system In normal adult serum the approximate percentage composition of IgA with respect to is subclasses is IgA1 90% and IgA2 10% In secretory IgA the subclass proportions may approach 50 50 The clinical significance of the subclasses has yet to be determined
ABclonal Technology 488 Rabbit anti-Human IL-17RB
The protein encoded by this gene is a cytokine receptor This receptor specifically binds to IL17B and IL17E but does not bind to IL17 and IL17C This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation which suggested the immunoregulatory activity of this receptor
ABclonal Technology 488 Rabbit anti-Human CD2
The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition A locus control region (LCR) has been found in the 3 flanking sequence of this gene
ABclonal Technology 594 Rabbit anti-Human CD142
This gene encodes coagulation factor III a cell surface glycoprotein that initiates blood coagulation cascades by acting as a high-affinity receptor for factor VII The complex formed activates specific proteolysis initiating coagulation Unlike other cofactors factor III is fully functional when expressed on cell surfaces like monocytes It has extracellular transmembrane and cytoplasmic domains Platelets and monocytes express this factor under procoagulatory and proinflammatory conditions and it plays a role in HIV-associated coagulopathy Factor III expression in platelets and monocytes is linked to COVID-19 severity and mortality Congenital deficiency of this factor has not been observed Alternative splicing produces multiple transcript variants
ABclonal Technology PE Rabbit anti-Human CD28 mAb
The protein encoded by this gene is essential for T-cell proliferation and survival cytokine production and T-helper type-2 development Several alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Human CD42b mAb
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer an alpha chain and a beta chain that is linked by disulfide bonds The Gp Ib functions as a receptor for von Willebrand factor (VWF) The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury and also initiates signaling events within the platelet that lead to enhanced platelet activation thrombosis and hemostasis This gene encodes the alpha subunit Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy
ABclonal Technology 450 Rabbit anti-Human CD45RA
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported