Rabbit Secondary Antibodies
ABclonal Technology APC Rabbit anti-Mouse CD44 mAb
This gene enables hyaluronic acid and type II TGF-beta receptor binding contributing to cytokine binding and receptor activity It regulates T cell activation protein phosphorylation and intracellular signaling Involved in Wnt signaling epithelium morphogenesis and wound healing it plays a role in inflammatory response Located in the basolateral plasma membrane external plasma membrane and microvilli it is part of the macrophage migration inhibitory factor receptor complex Expressed in various systems including alimentary branchial arch CNS genitourinary and limb Human orthologs are linked to breast carcinoma multiple carcinomas and prostate cancer It is orthologous to human CD44 a molecule in the Indian blood group
ABclonal Technology PerCP Rabbit anti-Mouse CD45
This gene encodes a protein with heparan sulfate proteoglycan binding heparin binding and protein tyrosine phosphatase activities It plays roles in lymphocyte differentiation regulation of macromolecule metabolism and signal transduction It is involved in processes such as lymphocyte activation and protein phosphorylation The protein is located on the plasma membrane focal adhesions and membrane rafts and is expressed in structures like the 3rd branchial arch alimentary system cardiovascular system and placenta It is used in studies of systemic lupus erythematosus Its human ortholog is linked to diseases like hepatitis C multiple sclerosis and severe combined immunodeficiency It is orthologous to human PTPRC (protein tyrosine phosphatase receptor type C)
ABclonal Technology PE Rabbit anti-Human mGluR2
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology putative signal transduction mechanisms and pharmacologic properties Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C Group II includes GRM2 and GRM3 while Group III includes GRM4 GRM6 GRM7 and GRM8 Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities Several transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology 647 Rabbit anti-Human CD314
Natural killer (NK) cells are lymphocytes capable of lysing tumor and virus-infected cells without prior activation as well as regulating immunity NK cells express several calcium-dependent (C-type) lectins which influence their function The NKG2 gene family located in the NK complex includes genes expressed in NK cells This gene encodes a transmembrane protein with a C-type lectin domain binding ligands like MHC class I chain-related A and B proteins and UL-16 binding proteins Ligand-receptor interactions activate NK and T cells aiding immune system recognition of stressed cells This protein and its ligands are potential therapeutic targets for immune diseases and cancers Read-through transcription occurs between this gene and the upstream KLRC4 family member in the same cluster
ABclonal Technology 647 Rabbit anti-Human CD35
Complement receptor type 1 (CR1 CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells neutrophils monocytes and renal podocytes As a component of the host s innate immune system CR1 CD35 expressed on neutrophils and monocytes binds to ligands coated with complement opsonins C3b and C4b thereby promoting phagocytosis and pro-inflammatory cytokine production CR1 CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of multiple cofactors for factor-I-mediated cleavage and inactivation of C3b and C4b
ABclonal Technology 488 Rabbit anti-Human CD48
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins The encoded protein is found on the surface of lymphocytes and other immune cells dendritic cells and endothelial cells and participates in activation and differentiation pathways in these cells The encoded protein does not have a transmembrane domain however but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor Multiple transcript variants encoding different isoforms have been found for this gene
ABclonal Technology APC Rabbit anti-Human CD45 mAb
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 647 Rabbit anti-Human CD89
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils monocytes macrophages and eosinophils where it mediates immunologic responses to pathogens It interacts with IgA-opsonized targets and triggers several immunologic defense processes including phagocytosis antibody-dependent cell-mediated cytotoxicity and stimulation of the release of inflammatory mediators Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene
Jackson Immuno Research Labs AffiniPure Rabbit Anti-Human Lactoferrin
AffiniPure Rabbit Anti-Human Lactoferrin
Jackson Immuno Research Labs Fluorescein (FITC)-AffiniPure Rabbit Anti-Human Serum IgA α Chain Specific
Fluorescein (FITC)-AffiniPure Rabbit Anti-Human Serum IgA α Chain Specific
Jackson Immuno Research Labs Rhodamine Red-X-AffiniPure Rabbit Anti-Human Lactoferrin
Rhodamine Red-X-AffiniPure Rabbit Anti-Human Lactoferrin
ABclonal Technology 647 Rabbit anti-Human CD8b
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system The CD8 antigen acting as a coreceptor and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules The functional coreceptor is either a homodimer composed of two alpha chains or a heterodimer composed of one alpha and one beta chain Both alpha and beta chains share significant homology to immunoglobulin variable light chains This gene encodes the CD8 beta chain isoforms Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described A pseudogene also located on chromosome 2 has been identified
ABclonal Technology APC Rabbit anti-Human CD44 mAb
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions cell adhesion and migration It is a receptor for hyaluronic acid (HA) and can also interact with other ligands such as osteopontin collagens and matrix metalloproteinases (MMPs) This protein participates in a wide variety of cellular functions including lymphocyte activation recirculation and homing hematopoiesis and tumor metastasis Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms however the full length nature of some of these variants has not been determined Alternative splicing is the basis for the structural and functional diversity of this protein and may be related to tumor metastasis
ABclonal Technology 647 Rabbit anti-Human CD58
This gene encodes a member of the immunoglobulin superfamily The encoded protein is a ligand of the T lymphocyte CD2 protein and functions in adhesion and activation of T lymphocytes The protein is localized to the plasma membrane Alternatively spliced transcript variants have been described