Rat Secondary Antibodies
ABclonal Technology APC anti-Human CD162/PSGL-1
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P- E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes As such this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins This protein requires two post-translational modifications tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans for its high-affinity binding activity Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response Alternate splicing results in multiple transcript variants
ABclonal Technology PE Rabbit anti- CD162/PSGL-1
Involved in leukocyte adhesive activation Acts upstream of or within leukocyte tethering or rolling Predicted to be located in plasma membrane raft and uropod Predicted to be active in plasma membrane Is expressed in brain and thymus primordium Human ortholog(s) of this gene implicated in carotid artery disease Orthologous to human SELPLG (selectin P ligand)
Cayman Chemical Rat PRoxIsome ProlIfRatrA 96
An antifolate with anticancer activity an inhibitor of thymidylate synthase and dihydrofolate reductase (Kis 109 and 7 nM respectively) has increased potency for thymidylate kinase when polyglutaminated (Ki 1.3 nM) an inhibitor of glycinamide ribonucleotide formyltransferase (Kis 9300 and 65 nM for the non-glutaminated and polyglutaminated enzyme) and aminoimidazole carboxamide ribonucleotide formyltransferase (Kis 3600 and 265 nM for the non-glutaminated and polyglutaminated respectively) inhibits proliferation of CCRF-CEM cells but not 510-dideazatetrahydrofolate-resistant CR15 cells (IC50s 0.254 and 200 UM respectively) reduces tumor growth in A549 H1299 and PC-9 NSCLC mouse xenograft models but not in models using the same cell lines overexpressing thymidylate kinase