MW 285.39 g/mol, Purity >98%. First selective small conductance Ca²+-activated K+ channel (SK) activator. Selectively opens SK2 and SK3 channels (EC₅₀ values are 5.6 and 14 μM, respectively). Shows no activity at SK1 and IK. Additionally reduces activity and excitability of dopamine neurons. Active in vivo.
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