Apoptosis Reagents and Kits
Abcam ANNEXIN V-CY3 APOPTOSIS STAINI ..
ANNEXIN V-CY3 APOPTOSIS STAINI ..
The product is subject to the following: Abcam Restricted Use Statement
ATCC Daoy; Medulloblastoma; Human (Homo sapiens)
Daoy is a polygonal cell that was isolated from the cerebellum of a 4-year-old, White, male with desmoplastic cerebellar medulloblastoma. The biopsy tumor was taken from the posterior fossa. The cell line Daoy Med can be used in neuroscience research.
Diagnostic Biosystems CASPASE 1 Caspase 1/Interleukin-1-β Converting Enzyme
Caspase 1 and is expressed as a proenzyme in many tissues. Active Caspase 1 is a tetramer of two subunits p10 and p20 in 2:2 ratio. Overexpression of caspase 1 can induce apoptosis in fibroblast, which can be inhibited by overexpression of Crm A, a protein from pox virus.
Diagnostic Biosystems CASPASE 3 Caspase 3/CPP32
This antibody is specific to a 32 kDa protein, which is identified as Caspase 3. Caspase 3 is associated with induction of apoptosis. Caspase 3 is ubiquitously expressed and is synthesized as an inactive proenzyme.
Selleck Chemical LLC Ac-DEVD-CHO 2mg 169332-60-9 Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO
Ac-DEVD-CHO (Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO) is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Ac-DEVD-CHO 5mg 169332-60-9 Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO
Ac-DEVD-CHO (Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO) is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC ML-7 HCl 10mg 110448-33-4
ML-7 is an inhibitor of smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 ¿M and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. ML-7 also inhibits PKA and PKC with Ki of 21 ?M and 42 ?M, respectively. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC ABT-737 10mM/1mL 852808-04-9
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Z-IETD-FMK 1mg 210344-98-2 Caspase-8 Inhibitor
Z-IETD-FMK (Caspase-8 Inhibitor) is a specific Caspase-8 inhibitor. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC HY-120142 5mg Medchemexpress, EC359 CAS:2012591-09-0 Purity:>98%
Medchemexpress, HY-120142 5mg EC359 CAS:2012591-09-0 EC359 is a potent, selective, high affinity and orally active leukemia inhibitory factor receptor (LIFR) inhibitor with a Kd of 10.2 nM, which directly interacts with LIFR to effectively block LIF/LIFR interactions. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Echelon Biosciences Research Labs Cell permeable caspase inhibitor I - 0.5 mg,
Cell permeable caspase inhibitor I - 0.5mg , Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO Category/Application: Caspase Inhibitor This item is non returnable
Biotium JC-1 Mitochondrial Membrane Potential Detection Kit (25 assays)
The loss of mitochondrial membrane potential is a hallmark for apoptosis. It is an early event preceding phosphatidylserine externalization and coinciding with caspase activation. JC-1 Mitochondrial Membrane Potential Detection Kit is used to measure mitochondrial membrane potential changes in cells. In non-apoptotic cells, JC-1 accumulates as aggregates in the mitochondrial membranes, resulting in red fluorescence (590 nm). The brightness of red fluorescence is proportional to the potential and varies among different cell types. However, in apoptotic and necrotic cells, which have diminished mitochondrial membrane potential, JC-1 exists in the green fluorescent (529 nm) monomeric form. This kit provides a step-by-step protocol and ready-to-use reagents for performing assays for flow cytometry, fluorescence microscopy, or fluorometric microplate reader.
Biotium Dual Apoptosis Assay with NucView 488 caspase-3 Substrate and Texas Red-Annexin V (50 - 250 assays)
These kits provides two apoptosis markers, our novel NucView 488 Caspase-3 Substrate and Annexin V conjugated with a dye, for profiling apoptotic cells and studying the relation of two important apoptosis events, caspase-3 activation and phosphatidylserine (PS) translocation. Annexin V conjugation for the second marker is available with the following dyes: Sulforhodamine 101 (Texas Red) Annexin V, CF594 Annexin V, and CF640R Annexin V. Unlike conventional caspase assays, NucView 488 Caspase-3 substrate detects caspase-3 activity within individual whole cells in a non-interfering manner. The substrate, which is both non-fluorescent and nonfunctional as a DNA dye, rapidly crosses cell membranes to enter the cytoplasm, where it is cleaved by caspase-3 to form a high-affinity DNA dye that stains the nucleus bright green. The kit contains reagents sufficient for 50 flow cytometry assays (200 uL assay volume).
Biotium Annexin V, CF350 Conjugate
Annexin V fluorescent conjugates can be used to detect apoptotic cells. The human anticoagulant Annexin V is a 35-36 kDa calcium-dependent phospholipid-binding protein with high affinity for phosphatidylserine (PS). In normal viable cells, PS is located on the inner leaflet of the cytoplasmic membrane. In apoptotic cells, however, PS is translocated from the inner to the outer leaflet of the plasma membrane, where it can be detected by fluorescently labeled Annexin V. CF Dye Annexin V Conjugates are provided at 50 ug/mL in buffer with azide as a preservative. CF dyes are Biotium's line of next-generation fluorescent dyes with advantages in brightness, photostability, and conjugate specificity compared to other fluorescent dyes. UV-excitable blue fluorescent CF350 dye has excitation/emission at 347/448 nm.