Modifying Enzymes
Biocare Medical, LLC Carezyme II: Pepsin - 25 ml
Pepsin is a commonly used digestive enzyme. For formalin-fixed paraffin-embedded tissues, certain antibody protocols require enzyme pretreatment for proper immuno-histochemical staining. This product is provided as a single-component, ready-to-use solution. It can also be used on an automated staining system.
Biocare Medical, LLC Protease XXIV
The staining pattern and intensity of signal for some IHC and ISH procedures can be improved by using an enzymatic pretreatment of the tissue sections. Digestive enzyme pretreatment is recommended prior to the addition of the primary antibody and/or probe. Always consult the protocol supplied with each primary antibody for optimal digestion conditions. It can also be used on an automated staining system.
Cayman Chemical N-Oleoyl GlutamIn 10mg
An endogenous N-acyl amine; induces mitochondrial uncoupling to increase respiration in C2C12 cells by 64% at 50 µM; inhibits capsaicin-induced calcium flux in HEK293A cells co-transfected with TRPV1 and RFP; reduces the number of acetic acid-induced abdominal constrictions, as well as formalin-induced paw licking in mice at 100 mg/kg
Cayman Chemical N-Oleoyl-L-phenylalnIn 1mg
An N-acyl amide; increases the OCR of mitochondria isolated from mouse brown adipose tissue in a Seahorse assay and decreases oligomycin-induced increases in the mitochondrial membrane potential in C2C12 cells, indicating mitochondrial uncoupling activity at 50 µM; reduces food intake and body weight of diet-induced obese mice at 30 mg/kg for 8 days
Qiagen Beverly Inc EXONUCLEASE III
Exonuclease, Exonuclease III; Conc. 100,000 U/ul; 50,000 U; incl. 10X buffer
ABclonal Technology Topoisomerase II alpha/TOP2A
This gene encodes a DNA topoisomerase an enzyme that controls and alters the topologic states of DNA during transcription This nuclear enzyme is involved in processes such as chromosome condensation chromatid separation and the relief of torsional stress that occurs during DNA transcription and replication It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another thus altering the topology of DNA Two forms of this enzyme exist as likely products of a gene duplication event The gene encoding this form alpha is localized to chromosome 17 and the beta gene is localized to chromosome 3 The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance Reduced activity of this enzyme may also play a role in ataxia-telangiectasia
Cayman Chemical CISD1 CytosolIc DomaInhumn
Source: Recombinant human N-terminal His-tagged CISD1 expressed in E. coli • Amino acids: 32-108 • MW: 11.3 kDa
Cayman Chemical Pentnoyl-Coenzyme AsodIum 1mg
A saturated acyl CoA and metabolite of 3-oxovalproyl-CoA; hepatic levels of pentanoyl-CoA and propionyl-CoA are increased in an Apc+/Min-FCCC mouse model of spontaneous colorectal cancer fed a low- or high-fat diet
Cayman Chemical N-Oleoyl GlutamIn 25mg
An endogenous N-acyl amine; induces mitochondrial uncoupling to increase respiration in C2C12 cells by 64% at 50 µM; inhibits capsaicin-induced calcium flux in HEK293A cells co-transfected with TRPV1 and RFP; reduces the number of acetic acid-induced abdominal constrictions, as well as formalin-induced paw licking in mice at 100 mg/kg
Medchemexpress LLC Topoisomerase II inhibitor 13 | 451515-89-2 | C22H23N9 | 5 MG
Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. It demonstrates antiproliferative activity against various cancer cells and induces apoptosis in cancer cells.
- Topoisomerase II (Topo II) inhibitor.
- Shows antiproliferative activity against several cancer cells.
- Induces cancer cell apoptosis.
- Exerts strong inhibitory effect on Topo II activity at 20 μM, and almost completely inhibits Topo II activity at 50 μM.
- Inhibits cancer cell proliferation with varying IC50s across different cell lines (e.g., A549, K562, Raji, HL-60, MDA-MB-231).
Enzo Life Sciences Cathepsin D (human liver), (purified) (25 µg)
Purity: ≥95% (SDS-PAGE). Formulation: Lyophilized with phosphate buffer. Source: Isolated from human liver. Long Term Storage: -80°C.