Modifying Enzymes
Cayman Chemical Hexnoyl-Coenzyme AsodIum s 1mg
A medium-chain fatty acyl CoA; the preferred acyl donor substrate for GOAT; a precursor in the biosynthesis of olivetolic acid
ABclonal Technology Topoisomerase II alpha/TOP2A
This gene encodes a DNA topoisomerase an enzyme that controls and alters the topologic states of DNA during transcription This nuclear enzyme is involved in processes such as chromosome condensation chromatid separation and the relief of torsional stress that occurs during DNA transcription and replication It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another thus altering the topology of DNA Two forms of this enzyme exist as likely products of a gene duplication event The gene encoding this form alpha is localized to chromosome 17 and the beta gene is localized to chromosome 3 The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance Reduced activity of this enzyme may also play a role in ataxia-telangiectasia
Sigma Aldrich Fine Chemicals Biosciences Neuraminidase from Clostridium perfringens (C. welchii) Suitable for manufacturing of diagnostic kits and reagents, Type V, lyophilized powder | 9001-67-6 | MFCD00131711 | 250UN
Neuraminidase from Clostridium perfringens (C. welchii) Suitable for manufacturing of diagnostic kits and reagents, Type V, lyophilized powder | 9001-67-6 | MFCD00131711 | 250UN
Medchemexpress LLC Fibrinogen (bovine) | 9001-32-5 | 92.0% | ≈340 kDa | 100MG
Bovine fibrinogen is a plasma glycoprotein supplied as a white to off-white powder for research applications in coagulation, thrombosis, and vascular biology. It is converted to fibrin by thrombin and is used in in vitro clotting assays and studies of inflammatory signaling in endothelial cells.
- White to off-white powder; soluble plasma glycoprotein.
- Used to study blood clotting, fibrin formation, thrombosis, and vascular inflammation.
- Activated by thrombin to assemble fibrin clots.
- Suitable for in vitro clotting assays and endothelial cell signaling studies.
- Stored per certificate of analysis; typically kept frozen for long-term storage (e.g., -20°C).
- Documentation available: datasheet, certificate of analysis, safety data sheet, and handling instructions.
- CAS number: 9001-32-5.
Biotang Inc Carbonic Anhydrase II E.coli Recombinant, Carbonic Anhydrase II E.coli, Synonyms Carbonic anhydrase 2, Carbonate dehydratase 2, can, cynT2, yadF, b0126, JW0122, Carbonic Anhydrase II.
Carbonic Anhydrase II E.coli Recombinant, Carbonic Anhydrase II E.coli, Synonyms Carbonic anhydrase 2, Carbonate dehydratase 2, can, cynT2, yadF, b0126, JW0122, Carbonic Anhydrase II.
Medchemexpress LLC Thp104c | 877792-12-6 | 99.0% | 376.43 g/mol | C20H16N4O2S | 5 MG
THP104c is a small-molecule inhibitor of mitochondrial fission (CAS 877792-12-6) intended for research use. The compound has molecular formula C20H16N4O2S and a molecular weight of 376.43 g/mol. It is supplied as an off-white to light yellow solid with reported high purity, and documentation such as a data sheet, COA, and SDS is available to support lab use.
- Inhibits mitochondrial fission for cell biology and mitochondrial research.
- High reported purity suitable for in vitro assays and biochemical studies.
- Off-white to light yellow solid for straightforward storage and handling.
- Available in multiple laboratory-scale quantities to support experiments.
- Includes COA and SDS for quality verification and safety information.
- For research use only; not for human or clinical use.
Sigma Aldrich Fine Chemicals Biosciences Choline Oxidase from Alcaligenes sp. lyophilized powder, >=10 units/mg solid | 9028-67-5 | MFCD00130787 | 1KU
Choline Oxidase from Alcaligenes sp. lyophilized powder, >=10 units/mg solid | 9028-67-5 | MFCD00130787 | 1KU
Enzo Life Sciences Matrix metalloproteinase-9 (MMP-9) fluorometric drug discovery kit, RED (1x96wells)
The MMP-9 Fluorometric (also known as fluorimetric) Drug Discovery Kit, RED is a complete assay system designed to screen MMP-9 inhibitors using a quenched fluorogenic substrate OMNIMMP RED: TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6-TAMRA)-Ala-Lys-NH2 [TQ3=quencher; GABA=4-aminobutyric acid; Cha=L-cyclohexylalanine; Abu=2-aminobutyric acid; Smc=S-methyl-L-cysteine; Dab=2,4-diaminobutyric acid; 6-TAMRA=6-tetramethylrhodamine]. TAMRA fluorescence is thoroughly quenched by the TQ3 group until cleavage by MMPs separates the two moieties. The assays are performed in a convenient 96-well microplate format. The kit is useful to screen inhibitors of MMP-9, a potential therapeutic target. The compound NNGH is also included as a prototypic control inhibitor. Alternative name: Gelatinase B, 92kDa Type IV collagenase. Applications: Fluorescent detection, HTS Activity assay.
Worthington Biochemical Corporation GALACTOSIDASE BETA 5KU
A partially purified, lyophilized powder. 2604-85-1
Bioss KD-Validated Topoisomerase II
DNA Topoisomerase II Alpha Primary Antibody Unconjugated Public Immunogen Range 362-400/400 Host Species Rabbit Target Species Human Mouse Rat Clonality Monoclonal Applications WB FCM IC Concentration Lot dependent Size 50 ul Storage Buffer Supplied in PBS (pH 7 4) containing 50% glycerol and 0 02% sodium azide
LifeSensors SUMOSTAR PROTEASE 1000 UNITS
Recombinant SUMOstar Protease 1 specifically recognizes and cleaves the SUMOstar tag from recombinant fusion proteins made with SUMOstar expression systems (Cat.#s: 1100A, 1106, 1100K, 1101, 2100, 2101, 2160, 2161, 3100, 3101, 7110, 7111, 7120, 7121). Unlike thrombin, EK, or TEV proteases, which recognize short, linear sequences, SUMOstar Protease 1 recognizes the tertiary structure of SUMOstar. As a result, SUMOstar Protease 1 will not cleave within the protein of interest. SUMOstar Protease 1 will not cleave SUMO-tags from proteins expressed with the SUMOpro or SUMOpro3 systems. To cleave the SUMOpro tag (orginial yeast SUMO tag), please use SUMO Protease 1 and to cleave SUMOpro3 tag please use SUMO Protease 2. This product contains 1000 units of SUMOstar Protease, where 1 U will cleave >90 µg of SUMOstar-GFP in 1 hour at 37C
Cayman Chemical Oleoyl-D-lysInsodIum salt 5mg
An inhibitor of GlyT2a; selectively inhibits GlyT2a (IC50 = 48.3 nM) over GlyT1b (IC50 = >3,000 nM) in Xenopus oocytes expressing the human transporters; reduces allodynia in a nerve ligation rat model of neuropathic pain at 30 mg/kg, i.p.
Cayman Chemical ANTIBODY KU-0058948 10mg
A PARP1 and PARP2 inhibitor (IC50s = 3.4 and 1.5 nM, respectively); selective for PARP1 over PARP3, PARP4, and tankyrase (IC50s = 40, 1,200, and >10,000 nM, respectively); selectively inhibits the survival of embryonic stem cells lacking Brca1 or Brca2 over embryonic stem cells expressing wild-type Brca1 or Brca2; decreases the survival and induces apoptosis in P39 and MUTZ-3 AML cells at 1 µM; potentiates MS-275-induced cytotoxicity in patient-derived AML cells at 5 nM; reduces survival in PTEN-deficient HCT116 cells but not those expressing wild-type PTEN or HCT116+/neo
Cayman Chemical Oleoyl-L-carnItInchlorIde 25mg
A long-chain acylcarnitine and GlyT2 inhibitor (IC50 = 340 nM); selective for GlyT2 over GlyT1 (IC50 = >10,000 nM); plasma levels are increased in patients with chronic kidney disease or end-stage renal disease receiving incident hemodialysis and these are associated with cardiovascular mortality
Enzo Life Sciences MMP-10 (catalytic domain) (human), (recombinant) (10 µg)
Alternative name: Matrix metalloproteinase 10, Stromelysin 2. Formulation: Liquid. In 50mM TRIS, 5mM CaCl2, 300mM NaCl, 20µM ZnCl2, 0.5% Brij-35, and 30% glycerol. Source: Produced in E. coli. Active Matrix Metalloproteinase-10 (MMP-10, stromelysin-2, transin-2) catalytic domain from human cDNA. The enzyme consists of the catalytic domain of human MMP-10 (Phe99-Glu271, NM_2425) with a C-terminal purification tag. This comprises an active form of MMP-10 which lacks the C-terminal hemopexin domain. MMPs lacking this domain cannot cleave native collagens; however, activity toward other targets such as gelatin, casein, or peptide substrates is unaffected. Long Term Storage: -80°C.