This simple procedure is based on the use of a unique single-buffer system and Zymo-Spin™ Column technology. Single stranded DNA or RNA (17 to 200 nucleotides; e.g., short transcripts, probes, primers) can be safely treated and recovered using this kit. The result is highlyconcentrated ( 6 l), purified DNA/RNA that is suitable for subsequent molecular methods including PCR, RT/PCR, hybridization, etc.