Nucleic Acid Synthesis
Glen Research Long Trebler Phosphoramidite, 0.25 g
Long Trebler Phosphoramidite is a special phosphoramidite building block designed for the synthesis of oligonucleotide dendrimers and complex branched DNA structures. It serves as a crucial branching reagent that enhances the properties of molecular biology applications. This phosphoramidite contributes to the stability of oligonucleotide dendrimers and improves the efficiency of PCR primer applications by making the resulting dendrimer strands resistant to degradation. It is particularly beneficial for nanotechnology applications and DNA chip technologies at higher temperatures.
- Facilitates synthesis of oligonucleotide dendrimers
- Increases stability and reduces exonuclease degradation
- Enables efficient attachment of modifier amidites
- Ideal for "bottom up" nano-assembly
- Suitable for DNA chip technology
- Intended for research use only
Enzo Life Sciences Dual-iODN (class I) (endotoxin-free) (synthetic) (100µg)
Inhibitory iODN oligodeoxynucleotide with phosphorothioate backbone. Sequence of an inhibitory ODN for in vivo use in rodents (50-150µg per injection): prototype class I that potently inhibits TLR9 and TLR7 signaling. Formulation: Lyophilized. Sterile. Long Term Storage: +4°C.
Apexbio Technology LLC 6-Thio-dG 789-61-7 5mg
6-Thio-2 -deoxyguanosine (6-Thio-dG CAS 789-61-7) is a nucleoside analogue that functions as a telomerase-mediated telomere targeting agent In telomerase-positive cancer cells 6-Thio-dG is incorporated into telomeric DNA inducing rapid telomere dysfunction independent of direct telomerase inhibition which leads to growth arrest and cell death In vitro cancer cell lines exhibit IC50 values ranging from 0 7 to 2 9 M indicating high sensitivity to the compound Normal cells with telomerase-silent status show minimal morphological effects upon 6-Thio-dG exposure In vivo 6-Thio-dG administration inhibits tumor growth and reduces proliferation markers in xenograft models The compound is valuable for investigating telomere biology and as a tool to evaluate telomerase-dependent therapeutic strategies in cancer research
Medchemexpress LLC Adenosine 5′-monophosphoramidate sodium | 102029-68-5 | 96.0% | 368.22 | 10 MG
Adenosine 5′-monophosphoramidate sodium is an adenosine derivative used as an intermediate for nucleotide synthesis. It significantly affects the accumulation of cyclic AMP.
- An adenosine derivative
- Can be used as an intermediate for nucleotide synthesis
- Significantly affects the accumulation of cyclic AMP
Cayman Chemical ANTIBODY SGC3027 1mg
A prodrug form of the PRMT7 inhibitor SGC8158; converted by intracellular reductases to SGC8158; inhibits methylation of Hsp70 in vitro (IC50 = 2.4 µM)
Selleck Chemical LLC 5-Methylcytidine
5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine It is found in ribonucleic acids of animal plant and bacterial origin
Medchemexpress LLC Guanosine triphosphate-13C10 dilithium | 86-01-1 | 99.4% | 544.97 | 1 MG
Guanosine triphosphate-13C10 (GTP-13C10) dilithium is a 13C-labeled version of Guanosine triphosphate (HY-113225), which is a native nucleotide. Derivatives of GTP may act as specific inhibitors against COVID-19.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development.
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
Cayman Chemical AdenosIn 5-dIphosphate 500mg
A central component of energy storage, metabolism, and signal transduction in vivo; a precursor for ATP and agonist of purinergic receptors
Medchemexpress LLC DMT-2′O-MOE-rG(ib) phosphoramidite | 251647-55-9 | MFCD31692297 | 95.0% | 913.99 | C47H60N7O10P | 1 ML
DMT-2′O-MOE-rG(ib) Phosphoramidite is a protected guanosine phosphoramidite for incorporation of 2'-O-methoxyethyl-modified guanosine in solid-phase oligonucleotide synthesis. It is supplied as a solid or as a ready-to-use 10 mM solution in DMSO and is suitable for stereochemical synthesis of phosphorothioate oligonucleotides and standard automated or manual coupling workflows.
- Provides 2'-O-MOE-modified guanosine monomer for oligonucleotide synthesis.
- Available as solid or ready-to-use 10 mM solution in DMSO.
- Supports stereochemical synthesis of phosphorothioate oligonucleotides.
- High purity for reliable coupling efficiency and product consistency.
- Compatible with automated and manual solid-phase synthesis protocols.
- Molecular formula and weight provided for analytical confirmation.