The 5'-Thiol Modifier C6 S-S CE-Phosphoramidite is a versatile chemical reagent designed for the targeted incorporation of thiol groups into oligonucleotides, which allows for easy post-synthesis modifications. Its unique disulfide bridge and C6 spacer facilitate effective thiol liberation, enhancing conjugation efficiency for various applications including biosensing and microarrays. Unlike other modifiers, it simplifies purification processes, making it suitable for diverse bioconjugation needs.