Nucleotides
Enzo Life Sciences Dual-iODN (class I) (endotoxin-free) (synthetic) (100µg)
Inhibitory iODN oligodeoxynucleotide with phosphorothioate backbone. Sequence of an inhibitory ODN for in vivo use in rodents (50-150µg per injection): prototype class I that potently inhibits TLR9 and TLR7 signaling. Formulation: Lyophilized. Sterile. Long Term Storage: +4°C.
Cayman Chemical NIcotInamIde N-oxIde 50g
A metabolite of nicotinamide; formed via oxidation of nicotinamide by CYP2E1; inhibits proliferation and induces reduction of NBT in HL-60 promyelocytic leukemia cells at 30 mM; levels in urine are elevated in a mouse model of high-fat diet-induced obesity
Medchemexpress LLC Guanosine triphosphate-15N5,d14 (dilithium) | 86-01-1 | 98.4% | 554.10 | 1 MG
Guanosine triphosphate-15N5,d14 dilithium is a deuterium and 15N labeled form of Guanosine triphosphate, a native nucleotide. Derivatives of GTP may be used as specific inhibitors against COVID-19. Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development, and deuteration can affect pharmacokinetic and metabolic profiles.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Enzo Life Sciences ODN 1826 (TLRGRADE™) (synthetic) (100µg)
CpG oligodeoxynucleotide (Type B) with phosphorothioate backbone. Specific ligand for mouse TLR9 (Toll-like receptor 9). Alternative name: CpG-B. Formulation: Lyophilized. Sterile. Long Term Storage: +4°C.
Enzo Life Sciences ODN 1585 (TLRGRADE™) (synthetic) (100µg)
CpG oligodeoxynucleotide (Type A) optimized for NK cell activation with mixed phosphodiester/phosphorothioate backbone. Specific ligand for mouse TLR9 (Toll-like receptor 9). Formulation: Lyophilized. Sterile. Long Term Storage: +4°C.
Qiagen Beverly Inc DNTP SOLUTION SET
A set of four concentrated 100mM solutions of the four natural deoxynucleotides.
Apexbio Technology LLC N1-Methylpseudo-UTP (D3) 50ul (100 mM)
N1-Methylpseudo-UTP D3 is a chemically modified nucleotide analog labeled with deuterium It is designed to substitute conventional uridine triphosphate during enzymatic transcription reactions allowing for the synthesis of isotope-labeled RNA N1-Methylpseudo-UTP D3 exerts its function through incorporation into RNA thereby conferring distinct structural and biochemical properties to RNA transcripts Based on these properties N1-Methylpseudo-UTP D3 holds research potential in structural analyses of RNA RNA-protein interaction studies and biophysical investigations including nuclear magnetic resonance (NMR) spectroscopy
Cayman Chemical AICA RIbonucleotIde 1mg
An AMPK activator; activates AMPK in a cell-free assay from 1-500 µM; inhibits lipolysis and lipogenesis in primary rat adipocytes from 100-500 µM; increases insulin sensitivity and prevents pancreatic β-cell damage in Zucker diabetic fatty rats at 0.5 mg/kg; induces cardiac mobilization and myofibroblast differentiation of endogenous CD44+CD45-/- MSCs, as well as decreases cardiac scar formation, in an aged mouse model of LAD occlusion-induced myocardial infarction at 0.5 mg/kg
Apexbio Technology LLC 7-Deaza-7-Propargylamino-dATP 50ul (100 mM)
7-Deaza-7-Propargylamino-dATP is a chemically modified nucleotide analog derived from deoxyadenosine triphosphate It is designed to enable enzymatic incorporation by DNA polymerases during DNA synthesis thereby facilitating site-specific labeling of DNA 7-Deaza-7-Propargylamino-dATP exerts its biological activity primarily through incorporation into nascent DNA strands introducing a terminal propargyl group that serves as a reactive alkyne handle for conjugation reactions via click chemistry approaches Based on these pharmacological properties 7-Deaza-7-Propargylamino-dATP holds research potential in DNA labeling fluorescent probe generation and studies of DNA polymerase activity specificity and DNA damage detection and repair mechanisms in molecular biology and biomedical research
Apexbio Technology LLC SpCas9 mRNA (ARCA 5mCTP ψUTP) 1mg (1mg/mL)
SpCas9 mRNA (ARCA 5mCTP UTP) encodes Streptococcus pyogenes Cas9 (SpCas9) protein This product can be used with purified guide RNA (gRNA) sequences in the CRISPR/Cas system for recognizing and cleaving genomic DNA targets CRISPR/Cas a defense system has been adapted from the Type II CRISPR/Cas system of S pyogenes for eukaryotic gene editing It requires two key components the Cas9 endonuclease and a non-coding gRNA Guided by a single gRNA Cas9 introduces DNA double-strand breaks (DSBs) at specific genomic sites Cells activate endogenous DNA repair pathways non-homologous end joining (NHEJ) or homology-directed repair (HDR) to repair the targeted DSB SpCas9 mRNA (ARCA 5mCTP UTP)is designed to mimick mature eukaryotic mRNA It contains a cap 0 structure generated via co-transcriptional capping Incorporation of modified nucleotides 5mCTP UTP poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vivo
![eMolecules 13085-50-2 | 2'-Deoxycytidine-5'-monophosphate disodium salt | Broadpharm | MFCD00672270 | 351.162 | C9H12N3Na2O7P | 0.000 | [Na+].[Na+].Nc1ccn([C@H]2C[C@H](O)[C@@H](COP([O-])([O-])=O)O2)c(=O)n1 | 1g | 761707650](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502459556.PNG-250.jpg)
eMolecules 13085-50-2 | 2'-Deoxycytidine-5'-monophosphate disodium salt | Broadpharm | MFCD00672270 | 351.162 | C9H12N3Na2O7P | 0.000 | [Na+].[Na+].Nc1ccn([C@H]2C[C@H](O)[C@@H](COP([O-])([O-])=O)O2)c(=O)n1 | 1g | 761707650
2'-Deoxycytidine-5'-monophosphate disodium salt | Broadpharm | 13085-50-2 | MFCD00672270 | 351.162 | C9H12N3Na2O7P | 0.000 | [Na+].[Na+].Nc1ccn([C@H]2C[C@H](O)[C@@H](COP([O-])([O-])=O)O2)c(=O)n1 | 1g | 761707650
Apexbio Technology LLC 5-Propargylamino-dCTP 10ul (100 mM)
5-Propargylamino-dCTP is a modified nucleoside triphosphate analog featuring a cytosine base with a propargylamino substituent introducing an alkyne functional group 5-Propargylamino-dCTP is incorporated into DNA strands mediated by DNA polymerases during active DNA synthesis This modification enables covalent conjugation to azide-bearing probes via copper-catalyzed azide-alkyne cycloaddition (CuAAC) Based on these pharmacological properties 5-Propargylamino-dCTP holds research potential in the detection and analysis of cellular proliferation DNA replication dynamics nucleic acid repair subcellular localization studies fluorescence labeling and molecular imaging-based nucleic acid research methodologies
Apexbio Technology LLC Ara-CTP 10ul (100 mM)
Ara-CTP is a sugar-modified nucleoside analogue composed of cytosine attached to arabinose phosphorylated as a triphosphate Ara-CTP exerts its biological activity primarily by incorporating into nucleic acid strands during nucleic acid synthesis thereby interfering with DNA polymerase and RNA polymerase activities Upon integration Ara-CTP disrupts nucleic acid elongation and replication steps resulting in strand termination or abnormal formation Based on these pharmacological properties Ara-CTP holds research potential in antiviral studies investigating viral replication mechanisms evaluating polymerase specificity identifying viral enzyme inhibitors and serving as a probe in biochemical assays exploring nucleotide-binding interactions and nucleic acid synthesis fidelity
Biotium Proliferation Viability Assays Enzyme Substrates Luciferase Substrates CellTiter Glo 1/EA
A luciferase-based ATP cell viability assay for high-throughput luminescence detection in microplates The homogenous assay offers high sensitivity wide dynamic range of over 3-4 orders of magnitude and long-lasting signal with a half-life of over 5 hours
![Revvity Health Sciences Inc UTP, [α-<sup>32</sup>P]- 800Ci/mmol 20mCi/ml EasyTide, 250 µCi](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00001872-502099600.JPG-250.jpg)
Revvity Health Sciences Inc UTP, [α-32P]- 800Ci/mmol 20mCi/ml EasyTide, 250 µCi
UTP, [α-32P]- 800Ci/mmol 20mCi/ml EasyTide, 250 µCi