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Nucleotides are composed of a nitrogenous base covalently bound to a 5-carbon sugar molecule and one or more phosphate functional groups. They are the molecules that make up the structural units of DNA and RNA.
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Acyclovir triphosphate sodium is the sodium salt of acyclovir's active triphosphate metabolite, supplied as a high-purity nucleotide analog for biochemical research. It acts as a chain-terminating inhibitor of viral polymerases and is used in enzymatic assays and nucleic acid studies.
High purity (HPLC 99.7%).
Molecular formula C8H14N5O12P3·xNa.
Functions as a nucleotide analog and polymerase inhibitor.
Provided in research-scale quantities and solution formats (e.g., 5 mg; 100 mM in water).
Intended for biochemical assays, polymerase inhibition studies, and nucleic acid research.
Typically stored frozen at -20 °C per supplier guidance.
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4-Thio-UTP is a nucleotide triphosphate analog in which the oxygen atom at the 4-position of uracil is substituted by a sulfur atom It can be incorporated into RNA molecules during in vitro transcription reactions producing RNAs containing 4-thiouridine modifications This modification provides unique advantages in studying protein interactions RNA modifications and RNA labeling Due to the presence of the sulfur atom RNA modified with 4-Thio-UTP can form cross-links with proteins upon ultraviolet (UV) irradiation facilitating the study of RNA-protein interactions Additionally 4-Thio-UTP can be employed in research on RNA folding and function as well as in studying the cellular localization and roles of RNA
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Digoxigenin-11-UTP is a modified nucleoside triphosphate used for labeling RNA probes It incorporates a digoxigenin label attached to uridine triphosphate (UTP) allowing it to be incorporated into RNA molecules during in vitro transcription reactions Digoxigenin is a non-radioactive label widely utilized in molecular biology experiments especially in situ hybridization (ISH) and Northern blotting RNA probes labeled with Digoxigenin-11-UTP exhibit high sensitivity and low background noise providing clear detection results Additionally the digoxigenin label binds specifically to anti-digoxigenin antibodies making the detection process both straightforward and highly efficient Digoxigenin-11-UTP serves as an essential tool for studying gene expression and RNA localization
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4-Thio-UTP is a nucleotide triphosphate analog in which the oxygen atom at the 4-position of uracil is substituted by a sulfur atom It can be incorporated into RNA molecules during in vitro transcription reactions producing RNAs containing 4-thiouridine modifications This modification provides unique advantages in studying protein interactions RNA modifications and RNA labeling Due to the presence of the sulfur atom RNA modified with 4-Thio-UTP can form cross-links with proteins upon ultraviolet (UV) irradiation facilitating the study of RNA-protein interactions Additionally 4-Thio-UTP can be employed in research on RNA folding and function as well as in studying the cellular localization and roles of RNA
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5-hme-CTP (5-hydroxymethylcytidine triphosphate) is a modified cytidine triphosphate bearing a hydroxymethyl group at the 5-position carbon This modification can enhance RNA stability and functionality During in vitro mRNA synthesis 5-hme-CTP can be incorporated into RNA molecules producing RNA containing 5-hydroxymethylcytidine Hydroxymethyl-modified RNA plays an essential role in studying RNA structure function and RNA-protein interactions Additionally 5-hme-CTP significantly improves RNA stability by reducing its intracellular degradation Thus this modified nucleotide has broad applications in gene expression research RNA-based drug development and gene therapy
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ARCA EGFP mRNA is a reporter mRNA suitable as a control reagent for studying transfection and expression efficiency in mammalian cells using various fluorescence-based methods Upon transfection of ARCA EGFP mRNA into the cytoplasm cells will express EGFP able to be characterized by strong bright green fluorescence upon excitation with excitation/emission maxima at 488 nm/509 nm respectively This product is provided as an mRNA capped at its 5 end and polyadenylated at its 3 end mimicking fully processed eukaryotic mRNA Advantages of mRNA transfection 1)No nuclear entry required mRNA directly translates to protein upon entry into the cytoplasm2)Faster protein expression compared to DNA transfection3)Promoter-independent protein expression4)No genomic integration risk5)Ideal for transfecting slowly dividing or non-dividing cells6)Protein expression directly correlates with the amount of transfected mRNA7)Transient expression protein is expressed within a limited timeframe
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Biotin-16-UTP is a biotin-labeled uridine triphosphate used for RNA detection and purification The biotin label allows RNA molecules to bind with streptavidin or anti-biotin proteins facilitating specific RNA detection and purification In in vitro transcription reactions Biotin-16-UTP can be incorporated into RNA molecules generating biotin-labeled RNA This labeled RNA has wide applications in RNA-protein interaction studies RNA detection and RNA purification Additionally biotin-labeled RNA can be applied in in vivo experiments to investigate RNA localization and function within cells
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Biotin-11-dCTP can be enzymatically incorporated into DNA via nick translation, random priming, or 3’-end terminal labeling. The number “11” is the number of atoms in the linker between biotin and dCTP. Properties: Colorless liquid; Store dessicated at -20⁰C; C28H42N7O16P3SLi4; MW: 885.4.
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Alternative Name: Cyanine 3-deoxyuridine-5'-triphosphate. Formulation: Liquid. Solution in water. Purity: ≥93% (HPLC). Appearance: Dark pink liquid. Use/Stability: Stable for at least one year after receipt when stored as recommended. Shipping: Shipped on Dry Ice. Long Term Storage: -20°C Excitation maximum: 550 nm Emission maximum: 564 nm. Handling: Protect from light. Avoid freeze/thaw cycles.
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