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Nucleotides are composed of a nitrogenous base covalently bound to a 5-carbon sugar molecule and one or more phosphate functional groups. They are the molecules that make up the structural units of DNA and RNA.
ScaleBio Single Cell methylation Nuclei Resuspension Kit, includes reagents to prepare nuclei post-isolation for the Single Cell Methylation Kit v1.1 workflow.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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An ionizable cationic lipid LNPs containing IZ-chol can be complexed with DNA with the plasmid-binding efficacy dependent in part on the type of helper lipids in the LNP formulation
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2-Thio-UTP is a base-modified ribonucleoside triphosphate commonly used in RNA-based biomedical research Incorporation of 2-Thio-UTP into RNA transcripts reduces innate immune activation compared to unmodified RNA Mechanistically RNAs transcribed with 2-Thio-UTP lack the ability to activate RNA-dependent protein kinase (PKR) markedly diminish 2 -5 -oligoadenylate synthetase (OAS) pathway induction decrease recognition by retinoic acid-inducible gene I (RIG-I) and suppress Toll-like receptor (TLR) mediated signaling Thus 2-Thio-UTP serves as a research tool in studies designing low-immunogenic RNAs for therapeutic applications
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