RNAi and RNA Reagents
ABclonal Technology KO Validated PHD2/EGLN1
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis This protein functions as a cellular oxygen sensor and under normal oxygen concentration modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3)
ABclonal Technology KO Validated SMARCB1/SNF5
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures allowing the transcriptional machinery to access its targets more effectively The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase This gene has been found to be a tumor suppressor and mutations in it have been associated with malignant rhabdoid tumors Alternatively spliced transcript variants have been found for this gene
ABclonal Technology KD Validated EIF2AK1
The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress The encoded protein is a kinase that can be inactivated by hemin Two transcript variants encoding different isoforms have been found for this gene
Apexbio Technology LLC EZ Cap ER-EGFP Probe mRNA (m1Ψ) 100ug (1mg/mL)
ER-EGFP mRNA encodes a fusion protein comprising an endoplasmic reticulum (ER) targeting signal sequence and enhanced green fluorescent protein (EGFP) EGFP is a widely used fluorescent marker protein for biological imaging By fusing EGFP to the ER signal sequence dynamic changes in the ER can be observed in real-time in live cells making it particularly useful for studying the structure function and interactions of the ER with other cellular organelles ER-EGFP s efficient fluorescent properties and specific localization to the ER position it as an ideal tool for studying ER-related processes The EZ Cap ER-EGFP Probe mRNA (m1 ) is provided at 1 mg/mL specifically designed for targeted expression of a green fluorescent protein label at the ER This mRNA is synthesized through co-transcriptional capping resulting in a Cap 1 structure The incorporation of m1 modifications poly(A) tail significantly enhances mRNA stability and lifetime both in vitro and in vivo
Medchemexpress LLC DSG Crosslinker 50mg | 79642-50-5 | 50 MG
Disuccinimidyl glutarate (DSG) is a homobifunctional N-hydroxysuccinimide (NHS) ester crosslinker used to conjugate primary amines in ADC synthesis and general bioconjugation workflows. It is supplied as a solid reagent for laboratory-scale crosslinking and protein modification.
- Reacts with primary amines to form stable amide bonds.
- Applicable to antibody-drug conjugate linker synthesis and peptide/protein crosslinking.
- Available in small, convenient pack sizes for research use.
- Molecular weight 326.26 g/mol and formula C13H14N2O8.
HORIZON DISCOVERY BIOSCIENCES LIMITED 10NMOL ON-TARGETPLUS HUMAN ROR
NC2459026 10NMOL ON-TARGETPLUS HUMAN ROR
Cayman Chemical MelnocortIn4 Receptr Repor 1ea
Cayman’s MC4R Reporter Assay consist of a 96-well plate coated with a transfection complex containing DNA constructs for MC4R and a cAMP response element regulated Secreted Alkaline Phosphatase (SEAP) reporter (MC4R Reverse Transfection Strip Plate). Cells grown on the transfection complex will express MC4R at the cell surface. Binding of agonists to MC4R initiates a signal transduction cascade resulting in expression of SEAP which is secreted into the cell culture media. SEAP activity is measured following addition of a luminescence-based alkaline phosphatase substrate provided in the kit.
HORIZON DISCOVERY BIOSCIENCES LIMITED OTPLUS HM MTCH2 23788 SP 5NMOL
ON-TARGETplus Human MTCH2 (23788) siRNA - SMARTpool, 5 nmo