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Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
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The protein encoded by this gene is part of the nuclear lamina a two-dimensional matrix of proteins located next to the inner nuclear membrane The lamin family of proteins make up the matrix and are highly conserved in evolution During mitosis the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated Lamin proteins are thought to be involved in nuclear stability chromatin structure and gene expression Vertebrate lamins consist of two types A and B Alternative splicing results in multiple transcript variants Mutations in this gene lead to several diseases Emery-Dreifuss muscular dystrophy familial partial lipodystrophy limb girdle muscular dystrophy dilated cardiomyopathy Charcot-Marie-Tooth disease and Hutchinson-Gilford progeria syndrome
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Protein ERGIC-53 Primary Antibody Unconjugated Public Immunogen Range 1-70/510 Host Species Rabbit Target Species Human Clonality Monoclonal Applications WB FCM IC Concentration Lot dependent Size 50 ul Storage Buffer Supplied in PBS (pH 7 4) containing 50% glycerol and 0 02% sodium azide
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Arrestin Beta 1 Primary Antibody Unconjugated Public Immunogen Range 1-48/418 Host Species Rabbit Target Species Human Mouse Clonality Monoclonal Applications WB FCM IC Concentration Lot dependent Size 50 ul Storage Buffer Supplied in PBS (pH 7 4) containing 50% glycerol and 0 02% sodium azide
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Programmed cell death protein 1 also known as PD-1 and CD279 is a protein found on the surface of cells that has a role in regulating the immune system s response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity
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G-Rich RNA Sequence Binding Factor 1 Primary Antibody Unconjugated Public Immunogen Range 100-150/480 Host Species Rabbit Target Species Human Clonality Monoclonal Applications WB FCM IC Concentration Lot dependent Size 50 ul Storage Buffer Supplied in PBS (pH 7 4) containing 50% glycerol and 0 02% sodium azide
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Accell siRNA SMARTpool reagents are designed for effective gene silencing in difficult-to-transfect cells. These reagents feature novel siRNA modifications that allow for delivery without the need for transfection reagents or viral vectors, making them suitable for a wide range of cell types including neuronal, immune, and primary cells.
Guaranteed gene silencing in difficult-to-transfect cells
Novel siRNA modified to require no transfection reagent or viral vector for delivery
Achieves targeted gene silencing in neuronal, immune, or primary cells
Guaranteed silencing by SMARTpool and 3 of 4 individual siRNAs
Novel siRNA modifications facilitate uptake, stability, specificity, and knockdown efficiency
Proven performance in neuronal, immunological, primary, and other difficult-to-transfect cell types
Extended-duration knockdown with optimized continuous application
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