Bioactive Small Molecules
Medchemexpress LLC F092 | 2250261-59-5 | MFCD28731551 | 99.79% | 359.38 | 1 MG
F092 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS) with a KD value of 0.14 nM. It can be used in the study of allergic and inflammatory responses.
- Inhibitor of hematopoietic prostaglandin D synthase (H-PGDS)
- Features a KD value of 0.14 nM
- Suitable for studying allergic responses
- Suitable for studying inflammatory responses
Cayman Chemical ANTIBODY NSC 15520 25mg
A small molecule inhibitor of RPA70 dsDNA binding; selectively inhibits dsDNA over ssDNA binding to RPA70 from 25-400 µM; inhibits the protein-protein interaction between p53 or Rad9 and RPA70
Medchemexpress LLC Fludrocortisone | 127-31-1 | 99.0% | 25 MG
Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. It is used in research for conditions such as congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency. It works by:
- Suppressing pro-inflammatory cytokine expression and reducing CCL2, IL-6, IL-8 levels.
- Upregulating mineralocorticoid receptor (MR) expression.
- Inducing PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation.
- Blocking Tau hyperphosphorylation, preventing apoptosis, and promoting survival and proliferation.
- Enhancing renal sodium and water transport, increasing plasma volume and blood pressure, and reducing plasma potassium and renin activity.
- Stimulating erythropoietin expression.
- Modulating uterine receptivity genes and reversing MUC1 upregulation.
Selleck Chemical LLC KB-0742 Dihydrochloride S9901-10MM/1ML
KB-0742 Dihydrochloride is a potent selective and orally bioavailable small molecule inhibitor of the transcription elongation cofactor CDK9 with IC50 of 6 nM for CDK9/cyclin T1 inhibition at 10 M ATP
Cayman Chemical Crotonosde 5mg
A guanosine analog with diverse biological activities; cytotoxic to P338, L5178Y, Sp2/O, HL-60, and Raji cells in vitro (EC50s = 21, 370, 120, 70, and 400 μM, respectively); reduces tumor growth by 60% in S-180 sarcoma and Ehrlich carcinoma solid tumor mouse models at 48 mg/kg per day for 12 days; has been used as an internal standard for the semi-quantitative analysis and comparison of RNA metabolites in MCF-7 breast cancer cells and MCF-10A mammary epithelial cells; decreases the force and rate of contraction in isolated guinea pig atria (EC50s = 2.8 and 17.8 μM, respectively); reduces carotid blood pressure in anesthetized cats at 0.5 μmol/kg
Selleck Chemical LLC Doxycycline Hyclate 100mg 24390-14-5
Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP). *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC BMS-986235 E4628-25MG
BMS-986235 (LAR-1219) is a selective orally active and potent agonist of formyl peptide receptor 2 (FPR2) with EC50 values of 0 41 nM and 3 4 nM for hFPR2 and mFPR2 respectively BMS-986235 therapy shows promising improvements in cardiac structure and function in a mouse model of heart failure highlighting its potential for preventing the progression of heart failure
TARGETMOL CHEMICALS INC ATRACTYLODIN 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Atractylodin (Atractydin) has high lipase inhibitory activity (IC539.12 uM); Atractylodin possesses strong repellency activities against T. castaneum adults (LD50 1.83 ug/cm). The repellency of Atractylodin (0.63 ug/cm) can achieve >90%. purity: 99%
Medchemexpress LLC GSK2018682 | 1034688-30-6 | 98.02% | 440.88 | 1 ML
GSK2018682 is an agonist for S1P1 and S1P5 receptors with pEC50s of 7.7 and 7.2, respectively, and exhibits no agonist activity towards human S1P2, S1P3, or S1P4. It is used in the research of multiple sclerosis. The appearance of GSK2018682 is a white to off-white solid. It is for research use only and not sold to patients. The compound has a molecular formula of C22H21ClN4O4. GSK2018682 can be dissolved in DMSO at a concentration of ≥ 125 mg/mL (283.52 mM) for in vitro use. For in vivo applications, various dissolution protocols are available using co-solvents like DMSO, PEG300, Tween-80, Saline, or Corn Oil. Stock solutions can be stored at -80°C for 2 years or -20°C for 1 year.
- Specific agonist activity for S1P1 and S1P5 receptors.
- Useful in multiple sclerosis research.
- Functions as a selective research tool for these targets and disease.
TARGETMOL CHEMICALS INC ROSAMULTIN 20MG
Also available in 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Rosamultin has antioxidant antiinflammatory/antinociceptive propertiesand has anti-human immunodeficiency virus (HIV) activity. purity: 99%
Cayman Chemical ANTIBODY PD 168393 1mg
A cell-permeable, irreversible inhibitor of EGFR kinase activity (IC50 = 0.70 nM); used in cells and in vivo to irreversibly inhibit EGFR signaling
Apexbio Technology LLC Tenovin-1, 25mg. Cas: 380315-80-0 MFCD: MFCD02914760. SIRT2 inhibitor, activates p53
Tenovin-1, a small molecule discovered by a cell-based screen, is a bio-active activator of p53 that elevates the levels of p53 protein, p53-downstream target p21CIP/WAF1 protein and mRNA and protects p53 from mdm2-mediated degradation with little impact on p53 synthesis. Other sizes are available. Please inqury us for quote.
Cayman Chemical ANTIBODY A17 100mg
A bile acid derivative; reduces oleic acid-induced triglyceride accumulation, increases cell viability, and decreases oleic acid-induced lipid peroxidation in primary rat hepatocytes at 10 and 25 µM; reduces levels of CD36 in primary rat hepatocytes at 25 µM; reduces serum triglyceride, total cholesterol, and LDL levels, reverses hepatic steatosis, and decreases hepatic triglyceride, but not total cholesterol, levels in a hamster model of high-fat diet-induced NASH at 50 mg/kg
AdipoGen 4-Diethylamino-hydroxyflavone
Chemical. CAS 146680-78-6. Formula C19H19NO3. MW 309.36. Synthetic. Fluorescent dye that exhibits dual band fluorescence emission which is sensitive to environmental factors. One band originates from the normal excited state N* and the other is due to the excited state intramolecular proton transfer ESPIT reaction product tautomer T*. An increase in solvent polarity and hydrogen bonding ability of the solvent leads to an increase in the population of the N* form relative to the T* form. The intensity ratio of the normal and tautomeric fluorescence bands are near 510nm and 570nm, with a main absorption band 370-420nm. There exists a latent third emission band peaked at 535nm, which is reliably recorded upon excitation at wavelengths of 470-500nm. The positions of the two bands, as well as their intensity ratios are sensitive to the local environment, making many of these compounds attractive ratiometric fluorescent sensors.