Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical ANTIBODY Eg5-I 10mg
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A potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively); blocks bipolar spindle formation and inhibits the growth of cancer cells, with an average GI50 value of 360 nM against a broad panel of tumor cells
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Cayman Chemical ANTIBODY CP 640 186 5mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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An ACC inhibitor (IC50s = 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively); lowers malonyl-CoA levels and inhibits hepatic fatty acid and triglyceride synthesis both in vitro and in vivo
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Cayman Chemical ANTIBODY KJ Pyr 9 25mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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A cell-permeable inhibitor of c-Myc (Kd = 6.5 nM) that interferes with Myc-Max complex formation; also potently blocks cell growth directed by overexpression of v-Myc; effective in vivo
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Cayman Chemical ANTIBODY SMI-481 5mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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An inhibitor of the yeast PITP Sec14, blocking both Sec14-mediated transfer of [3H]-PtdIns in vitro and growth (IC50s = 0.21 and 2.87 µM, respectively)
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Cayman Chemical ANTIBODY NU 6140 1mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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A Cdk2 inhibitor (IC50 = 0.41 μM) that demonstrates 10- to 36-fold selectivity against Cdk2-cyclin A compared to Cdk1-cyclin B, Cdk4-cyclin D, Cdk5-p25, or Cdk7-cyclin H; induces cell-cycle arrest at the G2-M phase
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Cayman Chemical ANTIBODY RS 504393 1mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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A selective antagonist of CCR2 (IC50s = 89 nM); inhibits MCP-1-stimulated chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Cayman Chemical PF-04981517 5mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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A potent, selective, and time-dependent inhibitor of CYP3A4 (IC50 = 30 nM)
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Cayman Chemical ANTIBODY tNPB 1mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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An analog of retinoic acid that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively); used to study RAR action in epidermal cell proliferation, embryogenesis, and stem cell differentiation
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Cayman Chemical ANTIBODY GIT 27 25mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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An immunomodulatory compound that inhibits inflammatory antigen presentation both in vitro and in preclinical in vivo models of autoimmune diseases; targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, macrophage migration inhibitory factor, and inducible nitric oxide synthase-mediated nitric oxide generation
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Cayman Chemical ANTIBODY BCECF 500ug
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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A fluorescent probe commonly used to measure pH
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Cayman Chemical ANTIBODY ML-347 10mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Selectively inhibits ALK1 (IC50 = 46 nM) and ALK2 (IC50 = 32 nM) with >300-fold selectivity over ALK3, ALK6, and VEGF type 2 receptor; inhibits BMP4 signaling with an IC50 value of 152 nM in a functional assay
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Cayman Chemical ANTIBODY SW033291 25mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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A potent inhibitor of 15-PGDH (Ki = ~0.1 nM) that has activity in vivo; rapidly increases the levels of PGE2 in bone marrow and other tissues in mice after intraperitoneal injection
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Cayman Chemical PexIdartInIb 10mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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A brain-penetrant inhibitor of CSF1R, as well as c-Kit and FLT3 (IC50s = 20, 10, and 160 nM in vitro, respectively); blocks macrophage recruitment in mammary tumor-bearing mice and blocks glioblastoma invasion in both cell culture and a mouse model of glioblastoma multiforme
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Cayman Chemical ANTIBODY LetermovIr 1mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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A small molecule inhibitor of human cytomegalovirus viral replication (EC50 = ~5 nM with a selectivity index >15,000) that targets viral DNA cleavage and packaging
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Cayman Chemical ANTIBODY BH3I-1 5mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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A cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis; inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki values of 43.4 and 124 µM, respectively
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