Protein Modification Reagents
Sigma Aldrich Fine Chemicals Biosciences Pepsin from porcine gastri100G
Pepsin from porcine gastri100G
Medchemexpress LLC Biotin-PEG1-NH2 | 811442-85-0 | >98.0% | 330.45 g/mol | C14H26N4O3S | 50 MG
Biotin-PEG1-NH2 is a single-unit polyethylene glycol (PEG1) linker bearing a biotin tag and a terminal primary amine. It is used as a cleavable ADC linker or bioconjugation handle to introduce biotin for detection, purification, or targeting in antibody-drug conjugates and other conjugation workflows.
- Cleavable one-unit PEG linker for ADC synthesis.
- Biotin tag enables affinity capture and detection.
- Terminal amine for coupling to activated esters or crosslinkers.
- High purity suitable for research applications.
- Powder form; store under low-temperature, dry conditions.
Medchemexpress LLC Mal-PEG4-VC-PAB-DMEA-PNU-159682 | 2259318-52-8 | 96.2% | 1559.62 | C74H98N10O27 | 1 MG
Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate used in antibody-drug conjugate (ADC) research. It combines a cleavable maleimide-PEG4-valine-citrulline-PAB-DMEA linker with a potent cytotoxic payload to enable studies of conjugation chemistry, linker stability, and payload release in vitro.
- Cleavable valine-citrulline peptide linker enabling enzymatic release.
- Maleimide functional group for thiol conjugation to antibodies.
- PEG4 spacer to improve solubility and spacing between antibody and payload.
- Conjugated to a potent cytotoxin for payload delivery studies.
- Supplied in small pack sizes suitable for early stage research.
Medchemexpress LLC N-Mal-N-bis(PEG4-NHS ester) | 2112738-60-8 | ≥95.0% | C37H54N4O19 | 100 MG
N-Mal-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It is designed for research applications, leveraging the intracellular ubiquitin-proteasome system for targeted protein degradation.
- PEG-based PROTAC linker
- Used for PROTAC synthesis
- Connects ligands for E3 ubiquitin ligase and target proteins
- Employs ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Dbco-PEG3-TCO | 2755573-20-5 | 98.0% | 631.76 g·mol⁻¹ | C36H45N3O7 | 50 MG
DBCO-PEG3-TCO is a heterobifunctional click-chemistry linker used for bioconjugation and antibody-drug conjugate (ADC) synthesis. It contains a dibenzocyclooctyne (DBCO) group for strain-promoted alkyne-azide cycloaddition and a trans-cyclooctene (TCO) group for rapid tetrazine ligation, joined by a three-unit polyethylene glycol (PEG3) spacer, enabling aqueous-phase conjugation and improved solubility.
- Facilitates catalyst-free azide-alkyne cycloaddition and tetrazine ligation
- Heterobifunctional design enables orthogonal dual conjugation strategies
- PEG3 spacer improves solubility and reduces steric hindrance
- High purity suitable for bioconjugation workflows
- Available in small milligram pack sizes for research use
Medchemexpress LLC Amino-PEG8-Boc | 756526-06-4 | 99.8% | 497.62 | C23H47NO10 | 250 MG
Amino-PEG8-Boc is an eight-unit polyethylene glycol (PEG) linker bearing a Boc-protected terminal amine. It is used as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs) and as a PEG-based linker for PROTACs and other bioconjugation chemistries.
- Cleavable 8-unit PEG linker
- Protecting group: Boc on terminal amine
- Suitable for antibody-drug conjugate synthesis
- Suitable for PROTAC linker construction
- Available as 250 mg research pack
- High purity for research use
Dojindo Molecular Technologies Inc FeBABE (1MG), 1-(p-Bromoacetamidobenzyl) ethylenediamine N,N,N EN E/em>-tetraacetic acid, acid iron(III)
Bromoacetamidobenzyl-EDTA (BABE) is a chelate labeling reagent that conjugates with sulfhydryl groups. The iron chelate of BABE (FeBABE) is a unique tool for determining the three-dimensional structure of proteins and the binding structures of protein-protein or protein-DNA complexes. BABE adds EDTA moieties to proteins through their sulfhydryl groups. Once attached to a protein, FeBABE cuts a nearby peptide or DNA chain. The cleavage site is within 12 angstroms of the FeBABE binding site. Iron (II)-chelate cleaves a peptide or DNA chain in the presence of hydrogen peroxide. The cleavage reaction completes quickly: 10 seconds to 20 minutes of incubation is sufficient. The size of the cleaved fragment is analyzed with gel electrophoresis such as SDS-PAGE.
Medchemexpress LLC Cc-885-ch2-peg1-nh-ch3 | 2722698-03-3 | 99.2% | 528.00 | C26H30ClN5O5 | 25 MG
CC-885-CH2-PEG1-NH-CH3 is a small-molecule neoDegrader used as the cytotoxic payload in antibody-based neoDegrader conjugates (AnDCs) to enable targeted protein degradation via the E3 ubiquitin ligase pathway. It is supplied for laboratory research use.
- Used in synthesis of antibody neoDegrader conjugates.
- Enables targeted protein degradation via the E3 ubiquitin ligase pathway.
- Molecular formula C26H30ClN5O5; molecular weight 528.00 g/mol.
- Purity 99.2% and solid, white to off-white appearance.
- Storage: 4°C (sealed); in solvent, -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC Mal-PEG2-Val-Cit-PABA | 1662687-83-3 | 98.9% | 590.63 | C27H38N6O9 | 5 MG
Mal-PEG2-Val-Cit-PABA is a cleavable antibody-drug conjugate (ADC) linker designed for synthesis of ADCs. It features a maleimide reactive handle, a PEG2 spacer for improved hydrophilicity, and a Val-Cit-PABA cleavage motif that enables protease-mediated release of payloads in target cells.
- Cleavable Val-Cit-PABA motif for protease-triggered payload release.
- Maleimide functional group for thiol-selective conjugation to antibodies.
- PEG2 spacer increases hydrophilicity and may reduce aggregation.
- High chemical purity suitable for research and ADC synthesis.
- Stable when stored as powder at -20°C; follow recommended solvent storage conditions.