Protein Modification Reagents
Medchemexpress LLC DSPE-PEG4-DBCO | 2112738-14-2 | 95.0% | C71H116N3O15P | 100 MG
DSPE-PEG4-DBCO is a PEG-based PROTAC linker employed in the synthesis of PROTACs. It serves as a click chemistry reagent, incorporating a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This mechanism leverages the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables SPAAC with azide-containing molecules
- Leverages the ubiquitin-proteasome system
- Achieves selective protein degradation
Medchemexpress LLC Biotin-PEG4-hydrazide | 756525-97-0 | 99.9% | C21H39N5O7S | 100 MG
Biotin-PEG4-hydrazide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Biotin-labeled
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Enables selective degradation of target proteins via the intracellular ubiquitin-proteasome system
Medchemexpress LLC TCO-PEG2-amine | 2141981-87-3 | 97.0% | C15H28N2O4 | 100 MG
TCO-PEG2-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. These molecules consist of two distinct ligands connected by a linker, where one targets an E3 ubiquitin ligase and the other targets the protein of interest. PROTACs function by harnessing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
Medchemexpress LLC Bromoacetamido-PEG2-C2-NHS ester | 1353011-78-5 | 95.0% | C13H19BrN2O7 | 50 MG
Bromoacetamido-PEG2-C2-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This compound has a molecular weight of 395.20 and appears as a white to off-white solid-liquid mixture.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Solid-liquid mixture, white to off-white in color
Medchemexpress LLC Dspe-peg 2000 | 892144-24-0 | 99.37% | (C2H4O)nC42H82NO10P | 500 MG
DSPE-PEG 2000 is a PEG polymer that incorporates DSPE and amine end groups. This compound can be effectively utilized for forming micelles, which are critical nanoparticles for advanced drug delivery systems.
- Forms micelles as nanoparticles
- Suitable for drug delivery applications
- Contains DSPE and amine end groups
eMolecules Broadpharm / m-PEG9-2-methylacrylate / 500mg / 354974920 / BP-23724 / / 35236-69-2 / MFCD30828683 / 496.594 / C23H44O11
Broadpharm / m-PEG9-2-methylacrylate / 500mg / 354974920 / BP-23724 / / 35236-69-2 / MFCD30828683 / 496.594 / C23H44O11
eMolecules Amino-Tri-(Azide-PEG4-ethoxymethyl)-methane | | | 500mg
Broadpharm | Amino-Tri-(Azide-PEG4-ethoxymethyl)-methane | 500mg | 591908411 | BP-25511 | 98.000 | | | 1070.210 | C43H83N13O18
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Broadpharm DBCO-PEG12 100mg
DBCO-PEG12-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids/ activated NHS esters/ carbonyls (ketone| aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound. Reagent grade for research purpose.
![eMolecules Broadpharm / SPDP-PEG-Mal MW 5000 / 500mg / 795361342 / BP-25331 / / / [null] / 482.570 / C20H26N4O6S2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502472917.JPG-250.jpg)
eMolecules Broadpharm / SPDP-PEG-Mal MW 5000 / 500mg / 795361342 / BP-25331 / / / [null] / 482.570 / C20H26N4O6S2
Broadpharm / SPDP-PEG-Mal MW 5000 / 500mg / 795361342 / BP-25331 / / / [null] / 482.570 / C20H26N4O6S2
eMolecules Fmoc-PEG4-NHS ester | 1314378-14-7 | MFCD20227659 | 1g
Broadpharm | Fmoc-PEG4-NHS ester | 1g | 229582925 | BP-20644 | 98.000 | 1314378-14-7 | MFCD20227659 | 584.622 | C30H36N2O10
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Medchemexpress LLC Biotin-PEG4-PFP ester | 1334172-58-5 | MFCD13184979 | 96.2% | 657.65 | C27H36F5N3O8S | 50 MG
Biotin-PEG4-PFP ester is an activated biotin linker containing a four-unit polyethylene glycol (PEG4) spacer and a pentafluorophenyl (PFP) ester leaving group. It is designed for efficient amine coupling and biotin tagging in bioconjugation workflows such as ADC and PROTAC synthesis.
- Cleavable PEG4 spacer provides flexibility and solubility
- PFP activated ester enables rapid coupling to primary amines
- Biotin tag allows affinity capture and detection
- Suitable for antibody-drug conjugate and probe labeling workflows
- Stable as a powder at -20°C for extended storage
Medchemexpress LLC Mal-amido-PEG24-acid | 2171095-70-6 | MFCD13184955 | 98.5% | C58H108N2O29 | 10MG
Mal-amido-PEG24-acid is a maleimide-functionalized PEG24 linker with an amido-linked terminal carboxylic acid designed for assembling PROTACs and other bioconjugates. It provides a hydrophilic PEG spacer to improve solubility and a maleimide group for thiol-selective conjugation. CAS 2171095-70-6; molecular weight 1297.47 g·mol⁻1; formula C58H108N2O29.
- Maleimide group for selective thiol conjugation.
- Amido-terminated PEG24 spacer with a terminal carboxylic acid for coupling versatility.
- Hydrophilic spacer improves solubility in aqueous media.
- High purity (98.5%) suitable for research-grade bioconjugation.
- Stable under recommended storage conditions for long-term use.
Medchemexpress LLC Mal-amido-PEG2-C2-acid | 756525-98-1 | 99.8% | 328.32 | 5 G
Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are compounds that utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein via a linker.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
Medchemexpress LLC Pomalidomide-PEG4-C-COOH | 2097938-44-6 | 99.2% | 507.49 | 5 MG
Pomalidomide-PEG4-C-COOH (Cereblon Ligand -Linker Conjugate 1) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Pomalidomide based cereblon ligand
- Uses 4-unit PEG linker
- Used in PROTAC technology
Medchemexpress LLC Pomalidomide-PEG4-C-COOH | 2097938-44-6 | 99.19% | 507.49 | 50 MG
Pomalidomide-PEG4-C-COOH (Cereblon Ligand -Linker Conjugate 1) is a synthesized E3 ligase ligand-linker conjugate that incorporates a Pomalidomide-based cereblon ligand and a 4-unit PEG linker, which are components used in PROTAC technology. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- A synthesized E3 ligase ligand-linker conjugate.
- Incorporates Pomalidomide based cereblon ligand.
- Includes a 4-unit PEG linker.
- Used in PROTAC technology.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.