Protein Modification Reagents
![eMolecules 2183473-14-3 | BDP FL-PEG4-amine TFA salt | Broadpharm510.390 | C24H37BF2N4O5 | 98.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCOCCOCCOCCOCCN)n1[B-]2(F)F | 100mg | 462125625](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203470.JPG-250.jpg)
eMolecules 2183473-14-3 | BDP FL-PEG4-amine TFA salt | Broadpharm510.390 | C24H37BF2N4O5 | 98.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCOCCOCCOCCOCCN)n1[B-]2(F)F | 100mg | 462125625
BDP FL-PEG4-amine TFA salt | Broadpharm | 2183473-14-3510.390 | C24H37BF2N4O5 | 98.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCOCCOCCOCCOCCN)n1[B-]2(F)F | 100mg | 462125625
Boston Bioproducts Inc PEG 8000 (30%) - 4x250ml
PEG 8000 (30%) - 4x250ml (For Research Use and Further Manufacturing Only)
Medchemexpress LLC DBCO-PEG8-NHS ester | 2553412-88-5 | 98.3% | C42H55N3O14 | 25 MG
DBCO-PEG8-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent features a DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs selectively degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- Functions as a click chemistry reagent
- Undergoes strain-promoted alkyne-azide cycloaddition
- Utilizes the ubiquitin-proteasome system for protein degradation
- Suitable for PROTAC synthesis
Medchemexpress LLC Mal-PEG3-NHS ester | 1537892-36-6 | 99.5% | 398.36 g/mol | C17H22N2O9 | 100 MG
Mal-PEG3-NHS ester is a noncleavable antibody-drug conjugate (ADC) linker containing a maleimide group and an N-hydroxysuccinimide (NHS) ester separated by a three-unit polyethylene glycol (PEG3) spacer. It enables conjugation to thiols and primary amines for bioconjugation and ADC synthesis in research applications.
- Provides thiol and amine reactive groups for versatile bioconjugation.
- PEG3 spacer increases aqueous solubility and reduces aggregation.
- High purity suitable for research and conjugation workflows.
- Available in multiple pack sizes for small- to mid-scale synthesis.
- Store protected from light and under inert gas to maintain stability.
Medchemexpress LLC N3-PEG2-C2-NHS ester | 1312309-64-0 | MFCD20926376 | 97.0% | 300.27 g/mol | C11H16N4O6 | 100 MG
N3-PEG2-C2-NHS ester is an azide-functional PEG2 linker supplied as an N-hydroxysuccinimide (NHS) ester for amine coupling and click-chemistry bioconjugation. It is used as a reagent in antibody-drug conjugate (ADC) synthesis and other bioconjugation workflows.
- Azide functional group enables copper-catalyzed and strain-promoted click chemistry.
- NHS ester allows rapid conjugation to primary amines.
- Peg2 spacer improves aqueous solubility and reduces steric hindrance.
- Non-cleavable two-unit linker suitable for stable bioconjugates.
- Supplied in small pack sizes for research use, suitable for analytical and preparative labeling.
Medchemexpress LLC DSPE-PEG-Amine, MW 5000 | 95.0% | 50 MG
DSPE-PEG-Amine, MW 5000 is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These molecules connect two ligands, one for an E3 ubiquitin ligase and another for a target protein, leveraging the intracellular ubiquitin-proteasome system to selectively degrade specific proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC t-Boc-Aminooxy-PEG4-NHS ester | 2401831-99-8 | 99.9% | C20H34N2O11 | 50 MG
t-Boc-Aminooxy-PEG4-NHS ester is a PEG-based PROTAC linker. It is used in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Bromoacetamido-PEG4-NHS ester | 1260139-70-5 | 98.7% | C17H27BrN2O9 | 50 MG
Bromoacetamido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Enables selective degradation of target proteins
- Utilizes the intracellular ubiquitin-proteasome system
Medchemexpress LLC M-PEG-NHS ester (MW 5000) | 92451-01-9 | 95.0% | (C2H4O)nC7H9NO5 | 100 MG
m-PEG-NHS ester (MW 5000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound facilitates the degradation of target proteins by exploiting the intracellular ubiquitin-proteasome system. It has an average molecular weight of 5000 and appears as a white to off-white solid. This product is for research use only.
- Peg-based protac linker
- Used in the synthesis of protacs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Average molecular weight of 5000
- White to off-white solid appearance
- For research use only
eMolecules 557756-85-1 | Fmoc-N-amido-PEG4-acid | Combi-Blocks | MFCD06656472 | 487.549 | C26H33NO8 | 97.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 117553694
Fmoc-N-amido-PEG4-acid | Combi-Blocks | 557756-85-1 | MFCD06656472 | 487.549 | C26H33NO8 | 97.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 117553694
eMolecules 557756-85-1 | Fmoc-NH-PEG4-CH2CH2COOH | ChemScene | MFCD06656472 | 487.549 | C26H33NO8 | 96.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100g | 799175051
Fmoc-NH-PEG4-CH2CH2COOH | ChemScene | 557756-85-1 | MFCD06656472 | 487.549 | C26H33NO8 | 96.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100g | 799175051
Medchemexpress LLC 4,7,10,13,16,19-hexaoxaheneicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester | 1599472-25-9 | MFCD20926374 | 98.0% | 530.52 | C23H34N2O12 | 100 MG
Mal-PEG6-NHS ester is a non-cleavable antibody-drug conjugate (ADC) linker composed of a maleimide group, a six-unit polyethylene glycol (PEG6) spacer, and an N-hydroxysuccinimide (NHS) ester that enables thiol and amine bioconjugation.
- Non-cleavable ADC linker suitable for antibody conjugation.
- Contains maleimide and NHS ester reactive groups.
- PEG6 spacer increases hydrophilicity and solubility.
- Purity 98.0% (NMR) and molecular weight ~530.52 g/mol.
- Soluble in DMSO at 100 mg/mL; may require sonication.
- Store at -20 °C and protect from light; stock solutions: -80 °C (6 months), -20 °C (1 month).
- CAS number 1599472-25-9.
Medchemexpress LLC Amino-PEG1-C2-acid | 144942-89-2 | 98.0% | 133.15 | 100 MG
Amino-PEG1-C2-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This product is for research use only. PROTACs function by containing two distinct ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to the target protein. They harness the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
- Suitable for research use only
Medchemexpress LLC DBCO-PEG2-DBCO | 2639395-48-3 | MFCD34178807 | 95.4% | 722.83 g/mol | C44H42N4O6 | 10 MG
DBCO-PEG2-DBCO is a bifunctional polyethylene glycol (PEG) linker bearing two terminal dibenzocyclooctyne (DBCO) groups. It is designed for copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) to enable bioconjugation without copper catalysts. The short PEG2 spacer increases solubility and flexibility, and the product is supplied with solubility and storage guidance for research use.
- Supports copper-free click chemistry (SPAAC)
- Contains two terminal DBCO reactive groups
- PEG2 spacer improves aqueous solubility and flexibility
- High reported purity suitable for research applications
- Soluble in DMSO; in vitro and in vivo formulation protocols provided
- Recommended storage as powder at -20°C for long-term stability
![Medchemexpress LLC Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]- | 1056024-94-2 | 98.0% | 247.25 | C9H17N3O5 | 10 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202206.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]- | 1056024-94-2 | 98.0% | 247.25 | C9H17N3O5 | 10 G
N3-PEG3-CH2CH2COOH is an azido-terminated PEG3 carboxylic acid linker used for click chemistry and as a PROTAC and ADC linker. It contains an azide functional group for copper-catalyzed and strain-promoted azide-alkyne conjugations, is supplied as a colorless to light yellow liquid, and is highly soluble in DMSO.
- Azide-containing PEG3 spacer for click chemistry.
- Compatible with CuAAC and SPAAC conjugation reactions.
- Purity 98.0% and liquid appearance (colorless to light yellow).
- High solubility in DMSO (100 mg/mL) and protocols for in vivo formulations.
- Store protected from light at -20°C; in solvent store at -80°C for long term.